Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine by Gwen Lomberk, Nelson Dusetti, Juan Iovanna, Raul Urrutia

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The Enduring Value of Research in Medical Education by Juliana Bonilla-Velez, Mariah Small, Raul Urrutia, Gwen Lomberk

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Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level by Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Angela J. Mathison, Angela J. Mathison, Tim Stodola, Douglas B. Evans, Douglas B. Evans, Jenica L. Abrudan, Wendy Demos, Michael Tschannen, Mohammed Aldakkak, Jennifer Geurts, Jennifer Geurts, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Susan Tsai, Susan Tsai, Susan Tsai, Raul Urrutia, Raul Urrutia, Raul Urrutia, Raul Urrutia

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Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction by Salomão Dória Jorge, Young-In Chi, Young-In Chi, Jose Lizarraga Mazaba, Neshatul Haque, Jessica Wagenknecht, Brian C. Smith, Brian C. Smith, Brian F. Volkman, Brian F. Volkman, Angela J. Mathison, Angela J. Mathison, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Raul Urrutia, Raul Urrutia, Raul Urrutia

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Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by A... by Guillermo Urrutia, Thiago Milech de Assuncao, Thiago Milech de Assuncao, Angela J. Mathison, Angela J. Mathison, Ann Salmonson, Romica Kerketta, Romica Kerketta, Atefeh Zeighami, Atefeh Zeighami, Timothy J. Stodola, Timothy J. Stodola, Volkan Adsay, Burcin Pehlivanoglu, Michael B. Dwinell, Michael B. Dwinell, Michael B. Dwinell, Michael B. Dwinell, Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Juan L. Iovanna, Raul Urrutia, Raul Urrutia, Raul Urrutia, Raul Urrutia, Raul Urrutia, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk

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Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. by Angela Mathison, Thiago Milech De Assuncao, Nikita R Dsouza, Monique Williams, Michael T Zimmermann, Raul Urrutia, Gwen Lomberk

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Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction by Nicolas A. Fraunhoffer, Analía Meilerman Abuelafia, Martin Bigonnet, Odile Gayet, Julie Roques, Remy Nicolle, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Juan Iovanna

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Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion. by Nidhi Jalan-Sakrikar, Thiago M De Assuncao, Jie Lu, Luciana L Almada, Gwen Lomberk, Martin E Fernandez-Zapico, Raul Urrutia, Robert C Huebert

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A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1 by Young-In Chi, Salomão D. Jorge, Davin R. Jensen, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

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NUPR1 protects against hyperPARylation-dependent cell death by Patricia Santofimia-Castaño, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

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Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma by Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, José Luis Neira, Juan Iovanna

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Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers by Young-In Chi, Timothy J. Stodola, Thiago M. De Assuncao, Elise N. Leverence, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

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Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer by Carla E Cano, María José Sandí, Tewfik Hamidi, Ezequiel L Calvo, Olivier Turrini, Laurent Bartholin, Céline Loncle, Véronique Secq, Stéphane Garcia, Gwen Lomberk, Guido Kroemer, Raul Urrutia, Juan L Iovanna

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Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cellsResearch in context by Nicolas A. Fraunhoffer, Aura I. Moreno Vega, Analía Meilerman Abuelafia, Marie Morvan, Emilie Lebarbier, Tristan Mary-Huard, Michael Zimmermann, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Yuna Blum, Remy Nicolle, Juan Iovanna

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KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells by Angela J. Mathison, Romica Kerketta, Thiago Milech de Assuncao, Elise Leverence, Atefeh Zeighami, Guillermo Urrutia, Timothy J. Stodola, Marina Pasca di Magliano, Juan L. Iovanna, Michael T. Zimmermann, Gwen Lomberk, Raul Urrutia

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Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis. by Angela Mathison, Adrienne Grzenda, Gwen Lomberk, Gabriel Velez, Navtej Buttar, Pamela Tietz, Helen Hendrickson, Ann Liebl, Yuning Y Xiong, Gregory Gores, Martin Fernandez-Zapico, Nicholas F Larusso, William Faubion, Vijay H Shah, Raul Urrutia

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Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction by Young-In Chi, Timothy J. Stodola, Thiago M. De Assuncao, Elise N. Levrence, Swarnendu Tripathi, Nikita R. Dsouza, Angela J. Mathison, Donald G. Basel, Brian F. Volkman, Brian C. Smith, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

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Correction to: Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction by Young-In Chi, Timothy J. Stodola, Thiago M. De Assuncao, Elise N. Levrence, Swarnendu Tripathi, Nikita R. Dsouza, Angela J. Mathison, Donald G. Basel, Brian F. Volkman, Brian C. Smith, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors by Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

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Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver FibrosisSummary by Rosa Martin-Mateos, Thiago M. De Assuncao, Juan Pablo Arab, Nidhi Jalan-Sakrikar, Usman Yaqoob, Thomas Greuter, Vikas K. Verma, Angela J. Mathison, Sheng Cao, Gwen Lomberk, Philippe Mathurin, Raul Urrutia, Robert C. Huebert, Vijay H. Shah

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