Collateral Victim or Rescue Worker?—The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer by Lishu He, Lishu He, Lishu He, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk

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Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine by Gwen Lomberk, Nelson Dusetti, Juan Iovanna, Raul Urrutia

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The Enduring Value of Research in Medical Education by Juliana Bonilla-Velez, Mariah Small, Raul Urrutia, Gwen Lomberk

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Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss by Gilda M. Kalinec, Gwen Lomberk, Raul A. Urrutia, Federico Kalinec

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Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level by Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Angela J. Mathison, Angela J. Mathison, Tim Stodola, Douglas B. Evans, Douglas B. Evans, Jenica L. Abrudan, Wendy Demos, Michael Tschannen, Mohammed Aldakkak, Jennifer Geurts, Jennifer Geurts, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Susan Tsai, Susan Tsai, Susan Tsai, Raul Urrutia, Raul Urrutia, Raul Urrutia, Raul Urrutia

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Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction by Salomão Dória Jorge, Young-In Chi, Young-In Chi, Jose Lizarraga Mazaba, Neshatul Haque, Jessica Wagenknecht, Brian C. Smith, Brian C. Smith, Brian F. Volkman, Brian F. Volkman, Angela J. Mathison, Angela J. Mathison, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Raul Urrutia, Raul Urrutia, Raul Urrutia

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Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by A... by Guillermo Urrutia, Thiago Milech de Assuncao, Thiago Milech de Assuncao, Angela J. Mathison, Angela J. Mathison, Ann Salmonson, Romica Kerketta, Romica Kerketta, Atefeh Zeighami, Atefeh Zeighami, Timothy J. Stodola, Timothy J. Stodola, Volkan Adsay, Burcin Pehlivanoglu, Michael B. Dwinell, Michael B. Dwinell, Michael B. Dwinell, Michael B. Dwinell, Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Juan L. Iovanna, Raul Urrutia, Raul Urrutia, Raul Urrutia, Raul Urrutia, Raul Urrutia, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk

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Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. by Angela Mathison, Thiago Milech De Assuncao, Nikita R Dsouza, Monique Williams, Michael T Zimmermann, Raul Urrutia, Gwen Lomberk

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Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas by Gareth Pollin, Gareth Pollin, Angela J. Mathison, Angela J. Mathison, Thiago M. de Assuncao, Thiago M. de Assuncao, Anju Thomas, Anju Thomas, Atefeh Zeighami, Ann Salmonson, Hongfei Liu, Guillermo Urrutia, Pallavi Vankayala, Stephen J. Pandol, Johnny C. Hong, Michael T. Zimmermann, Michael T. Zimmermann, Michael T. Zimmermann, Juan Iovanna, Victor X. Jin, Victor X. Jin, Raul Urrutia, Raul Urrutia, Raul Urrutia, Gwen Lomberk, Gwen Lomberk, Gwen Lomberk

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Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction by Nicolas A. Fraunhoffer, Analía Meilerman Abuelafia, Martin Bigonnet, Odile Gayet, Julie Roques, Remy Nicolle, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Juan Iovanna

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Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion. by Nidhi Jalan-Sakrikar, Thiago M De Assuncao, Jie Lu, Luciana L Almada, Gwen Lomberk, Martin E Fernandez-Zapico, Raul Urrutia, Robert C Huebert

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A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1 by Young-In Chi, Salomão D. Jorge, Davin R. Jensen, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

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Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance by Abdessamad El Kaoutari, Nicolas A. Fraunhoffer, Owen Hoare, Carlos Teyssedou, Philippe Soubeyran, Odile Gayet, Julie Roques, Gwen Lomberk, Raul Urrutia, Nelson Dusetti, Juan Iovanna

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Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation by Joohyun Kim, MD, PhD, Michael T. Zimmermann, PhD, Angela J. Mathison, PhD, Gwen Lomberk, PhD, Raul Urrutia, MD, Johnny C. Hong, MD

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NUPR1 protects against hyperPARylation-dependent cell death by Patricia Santofimia-Castaño, Can Huang, Xi Liu, Yi Xia, Stephane Audebert, Luc Camoin, Ling Peng, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

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Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma by Patricia Santofimia-Castaño, Yi Xia, Ling Peng, Adrián Velázquez-Campoy, Olga Abián, Wenjun Lan, Gwen Lomberk, Raul Urrutia, Bruno Rizzuti, Philippe Soubeyran, José Luis Neira, Juan Iovanna

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Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers by Young-In Chi, Timothy J. Stodola, Thiago M. De Assuncao, Elise N. Leverence, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia

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Disruption of FOXP3–EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal InflammationSummary by Adebowale O. Bamidele, Phyllis A. Svingen, Mary R. Sagstetter, Olga F. Sarmento, Michelle Gonzalez, Manuel B. Braga Neto, Subra Kugathasan, Gwen Lomberk, Raul A. Urrutia, William A. Faubion, Jr.

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Erratum To: Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer by Carla E Cano, María José Sandí, Tewfik Hamidi, Ezequiel L Calvo, Olivier Turrini, Laurent Bartholin, Céline Loncle, Véronique Secq, Stéphane Garcia, Gwen Lomberk, Guido Kroemer, Raul Urrutia, Juan L Iovanna

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Homotypic cell cannibalism, a cell‐death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer by Carla E. Cano, María José Sandí, Tewfik Hamidi, Ezequiel L. Calvo, Olivier Turrini, Laurent Bartholin, Céline Loncle, Véronique Secq, Stéphane Garcia, Gwen Lomberk, Guido Kroemer, Raul Urrutia, Juan L. Iovanna

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