Maintenance of tumor initiating cells of defined genetic composition by nucleostemin by Okamoto, Naoko, Yasukawa, Mami, Nguyen, Christine, Kasim, Vivi, Maida, Yoshiko, Possemato, Richard, Shibata, Tatsuhiro, Ligon, Keith L., Fukami, Kiyoko, Hahn, William C., Masutomi, Kenkichi

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MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma by Wood, Kris C., Konieczkowski, David J., Johannessen, Cory M., Boehm, Jesse S., Tamayo, Pablo, Botvinnik, Olga B., Mesirov, Jill P., Hahn, William C., Root, David E., Garraway, Levi A., Sabatini, David

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iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer by Lo, Justin H., Hao, Liangliang, Muzumdar, Mandar, Raghavan, Srivatsan, Kwon, Ester, Pulver, Emilia M, Hsu, Felicia, Aguirre, Andrew J., Wolpin, Brian M., Fuchs, Charles S., Hahn, William C., Jacks, Tyler E, Bhatia, Sangeeta N

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KRAS and YAP1 Converge to Regulate EMT and Tumor Survival by Shao, Diane D., Krall, Elsa B., Piccioni, Federica, Wang, Xiaoxing, Schinzel, Anna C., Rosenbluh, Joseph, Kim, Jong W., Zwang, Yaara, Roberts, Thomas M., Root, David E., Hahn, William C., Bhutkar, Arjun, Xue, Wen, Sood, Sabina, Jacks, Tyler E.

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RNF43 is frequently mutated in colorectal and endometrial cancers by Giannakis, Marios, Hodis, Eran, Jasmine Mu, Xinmeng, Yamauchi, Mai, Rosenbluh, Joseph, Cibulskis, Kristian, Saksena, Gordon, Lawrence, Michael S, Qian, Zhi Rong, Nishihara, Reiko, Van Allen, Eliezer M, Hahn, William C, Gabriel, Stacey B, Getz, Gad, Ogino, Shuji, Fuchs, Charles S, Garraway, Levi A, Lander, Eric Steven

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Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target by Watanabe, Hideo, Francis, Joshua M., Woo, Michele S., Etemad, Banafsheh, Lin, Wenchu, Fries, Daniel F., Peng, Shouyong, Snyder, Eric, Tata, Purushothama Rao, Izzo, Francesca, Schinzel, Anna C., Cho, Jeonghee, Hammerman, Peter S., Verhaak, Roel G., Hahn, William C., Rajagopal, Jayaraj, Meyerson, Matthew L., Jacks, Tyler E

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PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment by Collins, Natalie B, Al Abosy, Rose, Miller, Brian C, Bi, Kevin, Zhao, Qihong, Quigley, Michael, Ishizuka, Jeffrey J, Yates, Kathleen B, Pope, Hans W, Manguso, Robert T, Shrestha, Yashaswi, Wadsworth, Marc, Hughes, Travis, Shalek, Alex K, Boehm, Jesse S, Hahn, William C, Doench, John G, Haining, W Nicholas

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Cancer Vulnerabilities Unveiled by Genomic Loss by Nijhawan, Deepak, Zack, Travis I., Ren, Yin, Strickland, Matthew R., Lamothe, Rebecca, Schumacher, Steven E., Tsherniak, Aviad, Besche, Henrike C., Rosenbluh, Joseph, Shehata, Shyemaa, Cowley, Glenn S., Weir, Barbara A., Goldberg, Alfred L., Mesirov, Jill P., Root, David E., Beroukhim, Rameen, Hahn, William C., Bhatia, Sangeeta N

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Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells by Scholl, Claudia, Frohling, Stefan, Dunn, Ian F., Schinzel, Anna C., Barbie, David A., Kim, So Young, Silver, Serena J., Tamayo, Pablo, Wadlow, Raymond C., Ramaswamy, Sridhar, Dohner, Konstanze, Bullinger, Lars, Sandy, Peter, Boehm, Jesse S., Root, David E., Hahn, William C., Gilliland, D. Gary, Jacks, Tyler E

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Synergistic interactions with PI3K inhibition that induce apoptosis by Zwang, Yaara, Chen, Casandra, Rinne, Mikael L, Doench, John G, Piccioni, Federica, Tan, Li, Huang, Hai-Tsang, Wang, Jinhua, Ham, Young Jin, O'Connell, Joyce, Bhola, Patrick, Doshi, Mihir, Whitman, Matthew, Letai, Anthony, Root, David E, Gray, Nathanael, Hahn, William C, Jonas, Oliver H., Langer, Robert S, Cima, Michael J.

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PIK3CA mutant tumors depend on oxoglutarate dehydrogenase by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward

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Targeted Tumor-Penetrating siRNA Nanocomplexes for Credentialing the Ovarian Cancer Target ID4 by Ren, Yin, von Maltzhan, Geoffrey, Agrawal, Amit, Mesirov, Jill P., Lo, Justin H., Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Tamayo, Pablo, Karst, Alison M., Liu, Joyce F., Hirsch, Michelle S., Drapkin, Ronny, Root, David E., Fogal, Valentina, Ruoslahti, Erkki, Hahn, William C., Bhatia, Sangeeta N

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Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer by Viswanathan, Srinivas R., Nogueira, Marina F., Buss, Colin G., Krill-Burger, John M., Wawer, Mathias J., Malolepsza, Edyta, Berger, Ashton C., Choi, Peter S., Shih, Juliann, Taylor, Alison M., Tanenbaum, Benjamin, Pedamallu, Chandra Sekhar, Cherniack, Andrew D., Tamayo, Pablo, Strathdee, Craig A., Lage, Kasper, Carr, Steven A., Schenone, Monica, Bhatia, Sangeeta N., Vazquez, Francisca, Tsherniak, Aviad, Hahn, William C., Meyerson, Matthew

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BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc by Delmore, Jake E., Issa, Ghayas C., Lemieux, Madeleine E., Rahl, Peter B., Shi, Junwei, Jacobs, Hannah M., Kastritis, Efstathios, Gilpatrick, Timothy, Paranal, Ronald M., Qi, Jun, Chesi, Marta, Schinzel, Anna C., McKeown, Michael R., Heffernan, Timothy P., Vakoc, Christopher R., Bergsagel, P. Leif, Ghobrial, Irene M., Richardson, Paul G., Young, Richard A., Hahn, William C., Anderson, Kenneth C., Kung, Andrew L., Bradner, James E., Mitsiades, Constantine S.

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The bromodomain protein Brd4 insulates chromatin from DNA damage signalling by Floyd, Scott R., Pacold, Michael E., Huang, Qiuying, Clarke, Scott M., Rameseder, Jonathan, Lee, Michael J., Blake, Emily J., Fydrych, Anna, Ho, Richard, Del Rosario, Amanda M., Root, David E., Carpenter, Anne E., Hahn, William C., Sabatini, David M., Chen, Clark C., White, Forest M., Bradner, James E., Yaffe, Michael B., Lam, Fred Chiu-Lai, Cannell, Ian Gordon, Bryson, Bryan D., Greenberger, Benjamin Aaron, Chen, Grace, Maffa, Amanda D.

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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer by Ren, Yin, Meyerson, Matthew L., Drapkin, Ronny, Cheung, Hiu Wing, Cowley, Glenn S., Weir, Barbara A., Boehm, Jesse S., Rusin, Scott, Scott, Justine A., East, Alexandra, Ali, Levi D., Lizotte, Patrick H., Wong, Terence C., Jiang, Guozhi, Hsiao, Jessica, Mermel, Craig H., Getz, Gad, Barretina, Jordi, Gopal, Shuba, Tamayo, Pablo, Gould, Joshua, Tsherniak, Aviad, Stransky, Nicolas, Luo, Biao, Mesirov, Jill P., Garraway, Levi A., Lander, Eric S., Root, David E., Hahn, William C., Bhatia, Sangeeta N

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ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State by Chudnovsky, Yakov, Kim, Dohoon, Zheng, Siyuan, Whyte, Warren A., Bansal, Mukesh, Bray, Mark-Anthony, Gopal, Shuba, Theisen, Matthew A., Bilodeau, Steve, Thiru, Prathapan, Muffat, Julien, Yilmaz, Omer, Mitalipova, Maya, Woolard, Kevin, Lee, Jeongwu, Nishimura, Riko, Sakata, Nobuo, Fine, Howard A., Carpenter, Anne E., Silver, Serena J., Verhaak, Roel G.W., Califano, Andrea, Young, Richard A., Ligon, Keith L., Mellinghoff, Ingo K., Root, David E., Hahn, William C., Chheda, Milan G., Sabatini, David, Whyte, Warren Anthony

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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred Chiu-Lai, Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B, Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

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