Computational translation of genomic responses from experimental model systems to humans by Haigis, Kevin M., Brubaker, Douglas, Proctor, Elizabeth A, Lauffenburger, Douglas A

Get full text
Get full text
Get full text

Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation by Kreeger, Pamela K., Wang, Yufang, Haigis, Kevin M., Lauffenburger, Douglas A

Get full text

RAS Mutations Impact TNF-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits along with non-ERK Pathway Effects by Kreeger, Pamela K., Alford, Shannon K., Mandhana, Roli, Haigis, Kevin M., Lauffenburger, Douglas A

Get full text

RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects... by Kreeger, Pamela K., Mandhana, Roli, Haigis, Kevin M., Hughes-Alford, Shannon Kay, Lauffenburger, Douglas A

Get full text

BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner by Zhang, Tinghu, Kendall, Krystle R., Gray, Nathanael S., Haigis, Kevin M., Lau, Ken S., Lauffenburger, Douglas A

Get full text

Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-α by Lau, Ken S., Gierut, Jessica, Lauffenburger, Douglas A., Haigis, Kevin M., Schrier, Sarah, Lyons, Jesse Stolberg

Get full text
Get full text
Get full text

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium by Cortez-Retamozo, Virna, Philips, Sarah R., Pittet, Mikael J., Haigis, Kevin M., Lau, Ken S., Lauffenburger, Douglas A

Get full text

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-α-Induced Apoptosis and Proliferation by MAPKs by Lau, Ken S., Juchheim, Alwin M., Cavaliere, Kimberly R., Philips, Sarah R., Haigis, Kevin M., Lauffenburger, Douglas A

Get full text

Proapoptotic Function of the Retinoblastoma Tumor Suppressor Protein by Ianari, Alessandra, Natale, Tiziana, Calo, Eliezer, Ferretti, Elisabetta, Alesse, Edoardo, Screpanti, Isabella, Haigis, Kevin M., Gulino, Alberto, Lees, Jacqueline

Get full text
Get full text

Complete deletion of Apc results in severe polyposis in mice by Bronson, Roderick T., Haigis, Kevin M., Cheung, Ann, Carter, Alia, Kostova, Kamena K., Woodruff, Joe, Crowley, Denise G., Jacks, Tyler E

Get full text
Get full text

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer by Suarez-Lopez, Lucia, Kong, Yi Wen, Sriram, Ganapathy, Patterson, Jesse C, Rosenberg, Samantha, Morandell, Sandra, Haigis, Kevin M, Yaffe, Michael B

Get full text

MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer by Suarez-Lopez, Lucia, Kong, Yi Wen, Sriram, Ganapathy, Patterson, Jesse C., Rosenberg, Samantha, Morandell, Sandra, Haigis, Kevin M., Yaffe, Michael B.

Get full text

MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis by Haigis, Kevin M., Suarez Lopez, Lucia, Kong, Yi Wen, Sriram, Ganapathy, Morandell, Sandra M., Merrick, Karl Andrew, Hernandez, Yuliana I, Yaffe, Michael B

Get full text
Get full text
Get full text
Get full text
Get full text
Get full text

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation by Suarez-Lopez, Lucia, Shui, Bing, Brubaker, Douglas K, Hill, Marza, Bergendorf, Alexander, Changelian, Paul S, Laguna, Aisha, Starchenko, Alina, Lauffenburger, Douglas A, Haigis, Kevin M

Get full text

Identification of neurotoxic cytokines by profiling Alzheimer’s disease tissues and neuron culture viability screening by Wood, Levi B., Winslow, Ashley R., Proctor, Elizabeth A., McGuone, Declan, Mordes, Daniel A., Frosch, Matthew P., Hyman, Bradley T., Lauffenburger, Douglas A., Haigis, Kevin M.

Get full text
Get full text

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation by Brubaker, Douglas, Paulo, Joao A., Sheth, Shikha, Poulin, Emily J., Popow, Olesja, Joughin, Brian Alan, Strasser, Samantha Dale, Starchenko, Alina, Gygi, Steven P., Lauffenburger, Douglas A, Haigis, Kevin M.

Get full text

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile by Ghazi, Phaedra C., Tovaglieri, Alessio, Baldwin, Katherine R., Poulin, Emily J., Gierut, Jessica J., Genetti, Casie, Yajnik, Vijay, Breault, David T., Haigis, Kevin M., Lyons, Jesse Stolberg, Starchenko, Alina, Lauffenburger, Douglas A

Get full text
Get full text
Get full text

Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras-Driven Hematopoietic Transformation by Xu, Jin, Haigis, Kevin M., Firestone, Ari J., McNerney, Megan E., Li, Qing, Davis, Elizabeth, Chen, Shann-Ching, Nakitandwe, Joy, Downing, James, Le Beau, Michelle M., Shannon, Kevin, Jacks, Tyler E

Get full text
Get full text

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis by Ghazi, Phaedra C., Baldwin, Katherine R., Edwards, Amanda, Boukhali, Myriam, Lin, Yi-Jang, Yajnik, Vijay, Kissil, Joseph L., Haas, Wilhelm, Haigis, Kevin M., Lyons, Jesse Stolberg, Brubaker, Douglas, Strasser, Samantha Dale, Suarez Lopez, Lucia, Lauffenburger, Douglas A

Get full text
Get full text
Get full text
Get full text
Get full text

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice by Miraldi, Emily Rae, Sharfi, Hadar, Friedline, Randall H., Johnson, Hannah, Zhang, Tejia, Lau, Ken S., Ko, Hwi Jin, Curran, Timothy G., Haigis, Kevin M., Yaffe, Michael B., Bonneau, Richard, Lauffenburger, Douglas A., Kahn, Barbara B., Kim, Jason K., Neel, Benjamin G., Saghatelian, Alan, White, Forest M.

Get full text
Get full text
Get full text