Genetic polymorphisms and associated susceptibility to asthma by March ME, Sleiman PMA, Hakonarson H

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Cross-talk between T cells and airway smooth muscle cells in airway responsiveness by Heinzmann Andrea, Hakonarson H, Kim C, Whelan R, Campbell D, Grunstein MM

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Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. by Guo, Y, Lanktree, M, Taylor, K, Hakonarson, H, Lange, L, Keating, B

An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. by Fairfax, B, Vannberg, F, Radhakrishnan, J, Hakonarson, H, Keating, B, Hill, A, Knight, J

Burden of copy number variation in common variable immunodeficiency by Keller, M, Glessner, J, Resnick, E, Perez, E, Chapel, H, Lucas, M, Sullivan, K, Cunningham-Rundles, C, Orange, J, Hakonarson, H

Burden of copy number variation in common variable immunodeficiency. by Keller, M, Glessner, J, Resnick, E, Perez, E, Chapel, H, Lucas, M, Sullivan, K, Cunningham-Rundles, C, Orange, J, Hakonarson, H

CYP3A4 mutation causes vitamin D-dependent rickets type 3 by Roizen, J, Li, D, O'Lear, L, Javaid, M, Shaw, N, Ebeling, P, Nguyen, H, Rodda, C, Thummel, K, Thacher, T, Hakonarson, H, Levine, M

Genome-wide association identifies diverse causes of common variable immunodeficiency by Orange, J, Glessner, J, Resnick, E, Sullivan, K, Lucas, M, Ferry, B, Kim, C, Hou, C, Wang, F, Chiavacci, R, Kugathasan, S, Sleasman, J, Baldassano, R, Perez, E, Chapel, H, Cunningham-Rundles, C, Hakonarson, H

Genome-wide association identifies diverse causes of common variable immunodeficiency. by Orange, J, Glessner, J, Resnick, E, Sullivan, K, Lucas, M, Ferry, B, Kim, C, Hou, C, Wang, F, Chiavacci, R, Kugathasan, S, Sleasman, J, Baldassano, R, Perez, E, Chapel, H, Cunningham-Rundles, C, Hakonarson, H

TSLP-elicited basophil responses mediate the pathogenesis of eosinophilic esophagitis by Wojno, E, Noti, M, Kim, B, Siracusa, M, Giacomin, P, Nair, MG, Benitez, A, Ruymann, K, Muir, AB, Hill, D, Chikwava, K, Moghaddam, A, Sattentau, Q, Alex, A, Zhou, C, Menard-Katcher, P, Kubo, M, Obata-Ninomiya, K, Karasuyama, H, Comeau, MR, Brown-Whitehorn, T, Sleiman, P, Hakonarson, H, Cianferoni, A, Falk, G

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis. by Noti, M, Wojno, E, Kim, B, Siracusa, M, Giacomin, P, Nair, MG, Benitez, A, Ruymann, K, Muir, AB, Hill, D, Chikwava, K, Moghaddam, A, Sattentau, Q, Alex, A, Zhou, C, Yearley, J, Menard-Katcher, P, Kubo, M, Obata-Ninomiya, K, Karasuyama, H, Comeau, MR, Brown-Whitehorn, T, de Waal Malefyt, R, Sleiman, P, Hakonarson, H

Leprosy and the adaptation of human toll-like receptor 1. by Wong, S, Gochhait, S, Malhotra, D, Pettersson, F, Teo, Y, Khor, C, Rautanen, A, Chapman, S, Mills, T, Srivastava, A, Rudko, A, Freidin, M, Puzyrev, V, Ali, S, Aggarwal, S, Chopra, R, Reddy, B, Garg, V, Roy, S, Meisner, S, Hazra, S, Saha, B, Floyd, S, Keating, B, Kim, C, Fairfax, B, Knight, J, Hill, P, Adegbola, R, Hakonarson, H, Fine, P, Pitchappan, R, Bamezai, R, Hill, A, Vannberg, F, Hill, A

Phenome-wide association studies across large population cohorts support drug target validation by Diogo, D, Tian, C, Franklin, C, Alanne-Kinnunen, M, March, M, Spencer, C, Vangjeli, C, Weale, M, Mattsson, H, Kilpeläinen, E, Sleiman, P, Reilly, D, McElwee, J, Maranville, J, Chatterjee, A, Bhandari, A, Nguyen, K, Estrada, K, Reeve, M, Hutz, J, Bing, N, John, S, Macarthur, D, Salomaa, V, Ripatti, S, Hakonarson, H, Daly, M, Palotie, A, Hinds, D, Donnelly, P, Fox, C, Day-Williams, A, Plenge, R, Runz, H

Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study by Cleynen, I, Boucher, G, Jostins, L, Schumm, LP, Zeissig, S, Ahmad, T, Andersen, V, Andrews, JM, Annese, V, Brand, S, Brant, SR, Cho, JH, Daly, MJ, Dubinsky, M, Duerr, RH, Ferguson, LR, Franke, A, Gearry, RB, Goyette, P, Hakonarson, H, Halfvarson, J, Hov, JR, Huang, H, Kennedy, NA, Kupcinskas, L, Lawrance, IC, Lee, JC, Satsangi, J, Schreiber, S, Théâtre, E, Van Der Meulen-De Jong, AE, Weersma, RK, Wilson, DC, International Inflammatory Bowel Disease Genetics Consortium, Parkes, M, Vermeire, S, Rioux, JD, Mansfield, J, Silverberg, MS, Radford-Smith, G, McGovern, DPB, Barrett, JC, Lees, CW

De novo heterozygous POLR2A variants cause a neurodevelopmental syndrome with profound infantile-onset hypotonia by Haijes, H, Koster, M, Rehmann, H, Li, D, Hakonarson, H, Cappuccio, G, Hancarova, M, Lehalle, D, Reardon, W, Schaefer, G, Lehman, A, Van De Laar, I, Tesselaar, C, Turner, C, Goldenberg, A, Patrier, S, Thevenon, J, Pinelli, M, Brunetti-Pierri, N, Prchalová, D, Havlovicová, M, Vlckova, M, Sedláček, Z, Lopez, E, Ragoussis, V, Pagnamenta, A, Kini, U, Vos, H, Van Es, R, Van Schaik, R, Van Essen, T, Kibaek, M, Taylor, J, Sullivan, J, Shashi, V, Petrovski, S, Fagerberg, C, Martin, D, Van Gassen, K, Pfundt, R, Falk, M, McCormick, E, Timmers, H, Van Hasselt, P

Investigating the causal relationship of c-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium mendelian randomization study by Prins, B, Abbasi, A, Wong, A, Vaez, A, Nolte, I, Franceschini, N, Stuart, P, Guterriez Achury, J, Mistry, V, Bradfield, J, Valdes, A, Bras, J, Shatunov, A, Lu, C, Han, B, Raychaudhuri, S, Bevan, S, Mayes, M, Tsoi, L, Evangelou, E, Nair, R, Grant, S, Polychronakos, C, Radstake, T, van Heel, D, Dunstan, M, Wood, N, Al-Chalabi, A, Dehghan, A, Hakonarson, H, Markus, H, Elder, J, Knight, J, Arking, D, Spector, T, Koeleman, B, van Duijn, C, Martin, J, Morris, A, Weersma, R, Wijmenga, C, Munroe, P, Perry, J, Pouget, J, Jamshidi, Y, Snieder, H, Alizadeh, B

Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity by Yaghootkar, H, Zhang, Y, Spracklen, CN, Karaderi, T, Huang, LO, Bradfield, J, Schurmann, C, Fine, RS, Preuss, MH, Kutalik, Z, Wittemans, LB, Lu, Y, Metz, S, Willems, SM, Li-Gao, R, Grarup, N, Wang, S, Molnos, S, Sandoval-Zárate, AA, Nalls, MA, Lange, LA, Haesser, J, Guo, X, Lyytikäinen, L-P, Feitosa, MF, Sitlani, CM, Venturini, C, Mahajan, A, Kacprowski, T, Wang, CA, Chasman, DI, Amin, N, Broer, L, Robertson, N, Young, KL, Allison, M, Auer, PL, Blüher, M, Borja, JB, Bork-Jensen, J, Carrasquilla, GD, Christofidou, P, Demirkan, A, Doege, CA, Garcia, ME, Graff, M, Guo, K, Hakonarson, H, Hong, J, Ida Chen, Y-D, van Duijn, CM, Et al.

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. by Keating, B, Tischfield, S, Murray, S, Bhangale, T, Price, T, Glessner, J, Galver, L, Barrett, J, Grant, S, Farlow, D, Chandrupatla, H, Hansen, M, Ajmal, S, Papanicolaou, G, Guo, Y, Li, M, Derohannessian, S, de Bakker, P, Bailey, S, Montpetit, A, Edmondson, A, Taylor, K, Gai, X, Wang, S, Fornage, M, Shaikh, T, Groop, L, Boehnke, M, Hall, A, Hattersley, A, Frackelton, E, Patterson, N, Chiang, C, Kim, C, Fabsitz, R, Ouwehand, W, Price, A, Munroe, P, Caulfield, M, Drake, T, Boerwinkle, E, Reich, D, Whitehead, A, Cappola, T, Samani, N, Lusis, A, Schadt, E, Wilson, J, Koenig, W, McCarthy, M, Kathiresan, S, Gabriel, S, Hakonarson, H, Anand, S, Reilly, M, Engert, J, Nickerson, D, Rader, D, Hirschhorn, J, Fitzgerald, G

A genome-wide association meta-analysis identifies new childhood obesity loci by Bradfield, J, Taal, H, Timpson, N, Scherag, A, Lecoeur, C, Warrington, N, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, R, Schumacher, F, Cousminer, D, Sleiman, P, Zhao, J, Berkowitz, R, Vimaleswaran, K, Jarick, I, Pennell, C, Evans, D, St Pourcain, B, Berry, D, Mook-Kanamori, DO, Hofman, A, Rivadeneira, F, Uitterlinden, A, van Duijn, C, van der Valk, R, de Jongste, J, Postma, D, Boomsma, D, Gauderman, W, Hassanein, M, Lindgren, C, Mägi, R, Boreham, C, Neville, C, Moreno, L, Elliott, P, Pouta, A, Hartikainen, A, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, J, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, S, Kemp, J, Buxton, J, Blakemore, A, Bustamante, M, Guxens, M, Hirschhorn, J, Gillman, M, Kreiner-Møller, E, Bisgaard, H, Gilliland, F, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, T, Power, C, Palmer, L, Hinney, A, Widen, E, Farooqi, I, McCarthy, M, Froguel, P, Meyre, D, Hebebrand, J, Jarvelin, MR, Jaddoe, V, Smith, G, Hakonarson, H, Grant, S

Common variants at 12q15 and 12q24 are associated with infant head circumference. by Taal, H, St Pourcain, B, Thiering, E, Das, S, Mook-Kanamori, DO, Warrington, N, Kaakinen, M, Kreiner-Møller, E, Bradfield, J, Freathy, R, Geller, F, Guxens, M, Cousminer, D, Kerkhof, M, Timpson, N, Ikram, M, Beilin, L, Bønnelykke, K, Buxton, J, Charoen, P, Chawes, B, Eriksson, J, Evans, D, Hofman, A, Kemp, J, Kim, C, Klopp, N, Lahti, J, Lye, S, McMahon, G, Mentch, F, Müller-Nurasyid, M, O'Reilly, P, Prokopenko, I, Rivadeneira, F, Steegers, E, Sunyer, J, Tiesler, C, Yaghootkar, H, Breteler, M, Decarli, C, Breteler, M, Debette, S, Fornage, M, Gudnason, V, Launer, L, van der Lugt, A, Mosley, T, Seshadri, S, Smith, A, Vernooij, M, Blakemore, A, Chiavacci, R, Feenstra, B, Fernandez-Banet, J, Grant, S, Hartikainen, A, van der Heijden, A, Iñiguez, C, Lathrop, M, McArdle, W, Mølgaard, A, Newnham, J, Palmer, L, Palotie, A, Pouta, A, Ring, S, Sovio, U, Standl, M, Uitterlinden, A, Wichmann, H, Vissing, N, DeCarli, C, van Duijn, C, McCarthy, M, Koppelman, G, Estivill, X, Hattersley, A, Melbye, M, Bisgaard, H, Pennell, C, Widen, E, Hakonarson, H, Smith, G, Heinrich, J, Jarvelin, MR, Jaddoe, V