Combination therapy of a PSEN1-selective γ-secretase inhibitor with dexamethasone and an XPO1 inhibitor to target T-cell acute lymphoblastic leukemia by Charlien Vandersmissen, Cristina Prieto, Olga Gielen, Kris Jacobs, David Nittner, Johan Maertens, Heidi Segers, Jan Cools

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BCR-ABL1 positive B-ALL can undergo T-cell lineage shift to become CD19 negative T-ALL by Jolien De Bie, Sofie Demeyer, Olga Gielen, Heidi Segers, Lucienne Michaux, Peter Vandenberghe, Nancy Boeckx, Anne Uyttebroeck, Jan Cools

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Ruxolitinib Synergizes With Dexamethasone for the Treatment of T-cell Acute Lymphoblastic Leukemia by Delphine Verbeke, Olga Gielen, Kris Jacobs, Nancy Boeckx, Kim De Keersmaecker, Johan Maertens, Anne Uyttebroeck, Heidi Segers, Jan Cools

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Evaluating offspring Genomic and Epigenomic alterations after prenatal exposure to Cancer treatment In Pregnancy (GE-CIP): a multicentric observational study by Lode Godderis, Bernard Thienpont, Koenraad Devriendt, Frédéric Amant, Vera Wolters, Liesbeth Lenaerts, Kristel Van Calsteren, Thierry Voet, Ilana Struys, Carolina Velázquez, Heidi Segers, Ruben van Boxtel

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Single‐cell DNA and surface protein characterization of high hyperdiploid acute lymphoblastic leukemia at diagnosis and during treatment by Margo Aertgeerts, Sarah Meyers, Olga Gielen, Jochen Lamote, Barbara Dewaele, Mercedeh Tajdar, Johan Maertens, Jolien De Bie, Kim De Keersmaecker, Nancy Boeckx, Lucienne Michaux, Anne Uyttebroeck, Sofie Demeyer, Heidi Segers, Jan Cools

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Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing by Sarah Meyers, Llucia Alberti-Servera, Olga Gielen, Margot Erard, Toon Swings, Jolien De Bie, Lucienne Michaux, Barbara Dewaele, Nancy Boeckx, Anne Uyttebroeck, Kim De Keersmaecker, Johan Maertens, Heidi Segers, Jan Cools, Sofie Demeyer

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Immunoglobulin prophylaxis prevents hospital admissions for fever in pediatric acute lymphoblastic leukemia: results of a multicenter randomized trial by Kirsten A. Thus, Hester A. de Groot-Kruseman, Pauline Winkler-Seinstra, Marta Fiocco, Heidi Segers, Cor van den Bos, Inge M. van der Sluis, Wim J.E. Tissing, Margreet A. Veening, Christian Michel Zwaan, Cornelis M. van Tilburg, Rob Pieters, Marc Bierings

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Targeted therapies in children with renal cell carcinoma (RCC): An International Society of Pediatric Oncology—Renal Tumor Study Group (SIOP‐RTSG)‐related retrospective descriptive... by Julia Sprokkerieft, Justine N. van derBeek, Filippo Spreafico, Barbara Selle, Estelle Thebaud, Tanzina Chowdhury, Jesper Brok, Gábor Ottóffy, Xiaofei Sun, Gema L. Ramírez Villar, Garik Sagoyan, Heidi Segers, Dimitrios Doganis, Annalisa Serra, Lauriane Lemelle, Norbert Graf, Arnauld C. Verschuur, Godelieve A. M. Tytgat, Marry M. van denHeuvel‐Eibrink

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Randomized controlled trial on the effect of 1‐hour infusion of vincristine versus push injection on neuropathy in children with cancer (final analysis) by Aniek Uittenboogaard, Marleen H. van denBerg, Floor C. H. Abbink, Jos W. R. Twisk, Inge M. van derSluis, Cor van denBos, Marry M. van denHeuvel‐Eibrink, Heidi Segers, Christophe Chantrain, Jutte van derWerff ten Bosch, Leen Willems, Gertjan J. L. Kaspers, Mirjam Esther van deVelde

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The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer by Mirjam E. van deVelde, Marleen. H. van denBerg, Gertjan J. L. Kaspers, Floor C. H. Abbink, Jos W. R. Twisk, Inge M. van derSluis, Cor van denBos, Marry M. van denHeuvel‐Eibrink, Heidi Segers, Christophe Chantrain, Jutte van derWerff Ten Bosch, Leen Willems, Raphaële R. L. vanLitsenburg

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Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours by Lars Custers, Eleonora Khabirova, Tim H. H. Coorens, Thomas R. W. Oliver, Camilla Calandrini, Matthew D. Young, Felipe A. Vieira Braga, Peter Ellis, Lira Mamanova, Heidi Segers, Arie Maat, Marcel Kool, Eelco W. Hoving, Marry M. van den Heuvel-Eibrink, James Nicholson, Karin Straathof, Liz Hook, Ronald R. de Krijger, Claire Trayers, Kieren Allinson, Sam Behjati, Jarno Drost

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Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-me... by Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow

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Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia by Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock

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