OP 2.1 CCR5 in HIV Prevention and Cure by Helen L. Wu, Gabriela M. Webb, Jonah B. Sacha

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Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab by Nicholas Agresti, Jacob P. Lalezari, Phillip P. Amodeo, Kabir Mody, Steven F. Mosher, Harish Seethamraju, Scott A. Kelly, Nader Z. Pourhassan, C. David Sudduth, Christopher Bovinet, Ahmed E. ElSharkawi, Bruce K. Patterson, Reejis Stephen, Jonah B. Sacha, Helen L. Wu, Seth A. Gross, Kush Dhody

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CCR5 Receptor Occupancy Analysis Reveals Increased Peripheral Blood CCR5+CD4+ T Cells Following Treatment With the Anti-CCR5 Antibody Leronlimab by Xiao L. Chang, Helen L. Wu, Gabriela M. Webb, Meenakshi Tiwary, Colette Hughes, Jason S. Reed, Joseph Hwang, Courtney Waytashek, Carla Boyle, Cleiton Pessoa, Andrew W. Sylwester, David Morrow, Karina Belica, Miranda Fischer, Scott Kelly, Nader Pourhassan, Rachele M. Bochart, Jeremy Smedley, Christopher P. Recknor, Scott G. Hansen, Jonah B. Sacha, Jonah B. Sacha

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The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaqu... by Gabriela M Webb, Jhomary Molden, Kathleen Busman-Sahay, Shaheed Abdulhaqq, Helen L Wu, Whitney C Weber, Katherine B Bateman, Jason S Reed, Mina Northrup, Nicholas Maier, Shiho Tanaka, Lina Gao, Brianna Davey, Benjamin L Carpenter, Michael K Axthelm, Jeffrey J Stanton, Jeremy Smedley, Justin M Greene, Jeffrey T Safrit, Jacob D Estes, Pamela J Skinner, Jonah B Sacha

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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. by Glen M Chew, Tsuyoshi Fujita, Gabriela M Webb, Benjamin J Burwitz, Helen L Wu, Jason S Reed, Katherine B Hammond, Kiera L Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Brooks I Mitchell, Frederick M Hecht, Mario Ostrowski, Cecilia M Shikuma, Scott G Hansen, Mark Maurer, Alan J Korman, Steven G Deeks, Jonah B Sacha, Lishomwa C Ndhlovu

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Donor T cell chimerism correlates with viral reservoir clearance following allogeneic stem cell transplantation in fully cART-suppressed Mauritian cynomolgus macaques by Helen L. Wu, Whitney Weber, Shaheed A. Abdulhaqq, Christine Shriver-Munsch, Tonya Swanson, Mina Northrup, Kimberly Armantrout, Heidi Price, Mitchell Robertson-LeVay, Jason S. Reed, Katherine B. Bateman, Benjamin N. Bimber, Stephanie L. Junell, Rhonda MacAllister, Alfred W. Legasse, Michael K. Axthelm, Cassandra Moats, Jeremy Smedley, Theodore R. Hobbs, Lauren D. Martin, Gabrielle Meyers, Richard T. Maziarz, Benjamin J. Burwitz, Jeffrey J. Stanton, Jonah B. Sacha

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Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques by Benjamin J. Burwitz, Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, Mina Northrup, Benjamin N. Bimber, Thomas Jacob, Jason S. Reed, Reed Norris, Byung Park, Sven Moller-Tank, Knud Esser, Justin M. Greene, Helen L. Wu, Shaheed Abdulhaqq, Gabriela Webb, William F. Sutton, Alex Klug, Tonya Swanson, Alfred W. Legasse, Tania Q. Vu, Aravind Asokan, Nancy L. Haigwood, Ulrike Protzer, Jonah B. Sacha

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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14 by Bruce K. Patterson, Harish Seethamraju, Kush Dhody, Michael J. Corley, Kazem Kazempour, Jay Lalezari, Alina P.S. Pang, Christopher Sugai, Eisa Mahyari, Edgar B. Francisco, Amruta Pise, Hallison Rodrigues, Helen L. Wu, Gabriela M. Webb, Byung S. Park, Scott Kelly, Nader Pourhassan, Alina Lelic, Lama Kdouh, Monica Herrera, Eric Hall, Benjamin N. Bimber, Matthew Plassmeyer, Raavi Gupta, Oral Alpan, Jane A. O’Halloran, Philip A. Mudd, Enver Akalin, Lishomwa C. Ndhlovu, Jonah B. Sacha

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Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission by Xiao L. Chang, Gabriela M. Webb, Helen L. Wu, Justin M. Greene, Shaheed Abdulhaqq, Katherine B. Bateman, Jason S. Reed, Cleiton Pessoa, Whitney C. Weber, Nicholas Maier, Glen M. Chew, Roxanne M. Gilbride, Lina Gao, Rebecca Agnor, Travis Giobbi, Jeffrey Torgerson, Don Siess, Nicole Burnett, Miranda Fischer, Oriene Shiel, Cassandra Moats, Bruce Patterson, Kush Dhody, Scott Kelly, Nader Pourhassan, Diogo M. Magnani, Jeremy Smedley, Benjamin N. Bimber, Nancy L. Haigwood, Scott G. Hansen, Timothy R. Brown, Lishomwa C. Ndhlovu, Jonah B. Sacha

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Suppression of human and simian immunodeficiency virus replication with the CCR5-specific antibody Leronlimab in two species. by Xiao L Chang, Jason S Reed, Gabriela M Webb, Helen L Wu, Jimmy Le, Katherine B Bateman, Justin M Greene, Cleiton Pessoa, Courtney Waytashek, Whitney C Weber, Joseph Hwang, Miranda Fischer, Cassandra Moats, Oriene Shiel, Rachele M Bochart, Hugh Crank, Don Siess, Travis Giobbi, Jeffrey Torgerson, Rebecca Agnor, Lina Gao, Kush Dhody, Jacob P Lalezari, Ivo Sah Bandar, Alnor M Carnate, Alina S Pang, Michael J Corley, Scott Kelly, Nader Pourhassan, Jeremy Smedley, Benjamin N Bimber, Scott G Hansen, Lishomwa C Ndhlovu, Jonah B Sacha

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