Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family. ‌ Hillringhaus, L, Yue, W, Rose, N, Ng, S, Gileadi, C, Loenarz, C, Bello, S, Bray, J, Schofield, C, Oppermann, U

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases. ‌ Woon, E, Tumber, A, Kawamura, A, Hillringhaus, L, Ge, W, Rose, N, Ma, J, Chan, M, Walport, L, Che, K, Ng, S, Marsden, B, Oppermann, U, McDonough, M, Schofield, C

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases ‌ Chowdhury, R, Yeoh, K, Tian, Y, Hillringhaus, L, Bagg, E, Rose, N, Leung, I, Li, X, Woon, E, Yang, M, McDonough, M, King, O, Clifton, I, Klose, R, Claridge, T, Ratcliffe, P, Schofield, C, Kawamura, A

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. ‌ Chowdhury, R, Yeoh, K, Tian, Y, Hillringhaus, L, Bagg, E, Rose, N, Leung, I, Li, X, Woon, E, Yang, M, McDonough, M, King, O, Clifton, I, Klose, R, Claridge, T, Ratcliffe, P, Schofield, C, Kawamura, A

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases ‌ Chowdhury, R, Yeoh, K, Tian, Y, Hillringhaus, L, Bagg, E, Rose, N, Leung, I, Li, X, Woon, E, Yang, M, McDonough, M, King, O, Clifton, I, Klose, R, Claridge, T, Ratcliffe, P, Schofield, C, Kawamura, A