99 Structural optimization of anti-CEA-GITR-CAR to reduce tonic signaling and improve antigen-specific reactivity by Hiroshi Shiku, Yizheng Wang, Linan Wang, Takuma Kato

Modern T cell technologies for immunotherapy of solid tumors by M. S. Kuznetsova, Hiroshi Shiku, A. V. Karaulov, S. V. Sennikov

Get full text

The role of metabolism on regulatory T cell development and its impact in tumor and transplantation immunity by Aleksey S. Bulygin, Julia N. Khantakova, Nadezhda S. Shkaruba, Hiroshi Shiku, Sergey S. Sennikov

Get full text

αβ-T cell receptor transduction gives superior mitochondrial function to γδ-T cells with promising persistence by Mikiya Ishihara, Hiroshi Miwa, Hiroshi Fujiwara, Yasushi Akahori, Takuma Kato, Yoshimasa Tanaka, Isao Tawara, Hiroshi Shiku

Get full text

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells by Naohiro Seo, Yoshitaka Shirakura, Yoshiro Tahara, Fumiyasu Momose, Naozumi Harada, Hiroaki Ikeda, Kazunari Akiyoshi, Hiroshi Shiku

Get full text

Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induc... by Mikiya Ishihara, Naohiro Seo, Jun Mitsui, Daisuke Muraoka, Maki Tanaka, Junichi Mineno, Hiroaki Ikeda, Hiroshi Shiku

Get full text

A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy. by Nicholas Paul Casey, Hiroshi Fujiwara, Kazushi Tanimoto, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Masaki Yasukawa

Get full text

Guanine-Rich Sequences Are a Dominant Feature of Exosomal microRNAs across the Mammalian Species and Cell Types. by Fumiyasu Momose, Naohiro Seo, Yasushi Akahori, Shin-Ichi Sawada, Naozumi Harada, Toru Ogura, Kazunari Akiyoshi, Hiroshi Shiku

Get full text

Fully closed cell sorter for immune cell therapy manufacturing by Masahiro Matsumoto, Shinji Tashiro, Tatsumi Ito, Kazuya Takahashi, Gakuji Hashimoto, Junji Kajihara, Yoshihiro Miyahara, Hiroshi Shiku, Yoichi Katsumoto

Get full text

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity. by Hajime Kashima, Fumiyasu Momose, Hiroshi Umehara, Nao Miyoshi, Naohisa Ogo, Daisuke Muraoka, Hiroshi Shiku, Naozumi Harada, Akira Asai

Get full text

MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity by Naoko Imai, Hiroshi Shiku, Yoshihiro Miyahara, Linan Wang, Takuma Kato, Hiroshi Fujiwara, Hiroshi Miwa, Meiou Liu, Yasushi Akahori, Kohei Negishi

Get full text

Distinguishing functional exosomes and other extracellular vesicles as a nucleic acid cargo by the anion‐exchange method by Naohiro Seo, Junko Nakamura, Tsuguhiro Kaneda, Hiroaki Tateno, Asako Shimoda, Takanori Ichiki, Koichi Furukawa, Jun Hirabayashi, Kazunari Akiyoshi, Hiroshi Shiku

Get full text

MAGE-A4, NY-ESO-1 and SAGE mRNA expression rates and co-expression relationships in solid tumours by Mikiya Ishihara, Shinichi Kageyama, Yoshihiro Miyahara, Takeshi Ishikawa, Shugo Ueda, Norihito Soga, Hiroaki Naota, Katsumi Mukai, Naozumi Harada, Hiroaki Ikeda, Hiroshi Shiku

Get full text

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor. by Hiroaki Asai, Hiroshi Fujiwara, Jun An, Toshiki Ochi, Yukihiro Miyazaki, Kozo Nagai, Sachiko Okamoto, Junichi Mineno, Kiyotaka Kuzushima, Hiroshi Shiku, Hirofumi Inoue, Masaki Yasukawa

Get full text

Interleukin-17 induces an atypical M2-like macrophage subpopulation that regulates intestinal inflammation. by Kenichiro Nishikawa, Naohiro Seo, Mie Torii, Nei Ma, Daisuke Muraoka, Isao Tawara, Masahiro Masuya, Kyosuke Tanaka, Yoshiyuki Takei, Hiroshi Shiku, Naoyuki Katayama, Takuma Kato

Get full text

First Case of Cytokine Release Syndrome after Nivolumab for Gastric Cancer by Hiroyasu Oda, Mikiya Ishihara, Yoshihiro Miyahara, Junko Nakamura, Yuji Kozuka, Motoh Iwasa, Akira Tsunoda, Yoshiki Yamashita, Kanako Saito, Toshiro Mizuno, Hiroshi Shiku, Naoyuki Katayama

Get full text

Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses. by Kenshiro Tsuda, Keiichi Yamanaka, Wang Linan, Yoshihiro Miyahara, Tomoko Akeda, Takehisa Nakanishi, Hiroshi Kitagawa, Masato Kakeda, Ichiro Kurokawa, Hiroshi Shiku, Esteban C Gabazza, Hitoshi Mizutani

Get full text

TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors by Alaa Alsalloum, Saleh Alrhmoun, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Julia Lopatnikova, Vasily Kurilin, Marina Volynets, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov

Get full text

Evaluation of Production Protocols for the Generation of NY-ESO-1-Specific T Cells by Wenjie Gong, Lei Wang, Sophia Stock, Ming Ni, Maria-Luisa Schubert, Brigitte Neuber, Christian Kleist, Angela Hückelhoven-Krauss, Depei Wu, Carsten Müller-Tidow, Anita Schmitt, Hiroshi Shiku, Michael Schmitt, Leopold Sellner

Get full text

HDAC Inhibition for Optimized Cellular Immunotherapy of NY-ESO-1-Positive Soft Tissue Sarcoma by Wenjie Gong, Lei Wang, Maria-Luisa Schubert, Christian Kleist, Brigitte Neuber, Sanmei Wang, Mingya Yang, Angela Hückelhoven-Krauss, Depei Wu, Anita Schmitt, Carsten Müller-Tidow, Hiroshi Shiku, Michael Schmitt, Leopold Sellner

Get full text