The Hygiene Hypothesis and New Perspectives—Current Challenges Meeting an Old Postulate by Holger Garn, Holger Garn, Daniel Piotr Potaczek, Petra Ina Pfefferle, Petra Ina Pfefferle, Petra Ina Pfefferle

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Editorial: The Immunological Implications of the Hygiene Hypothesis by Petra Ina Pfefferle, Idoia Postigo, Holger Garn

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The Hygiene Hypothesis – Learning From but Not Living in the Past by Petra I. Pfefferle, Petra I. Pfefferle, Petra I. Pfefferle, Corinna U. Keber, Corinna U. Keber, Corinna U. Keber, Robert M. Cohen, Holger Garn, Holger Garn

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β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma. by Anton Volkov, Stefanie Hagner, Stephan Löser, Safa Alnahas, Hartmann Raifer, Anne Hellhund, Holger Garn, Ulrich Steinhoff

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Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells. by Laura E Layland, Kathrin Straubinger, Manuel Ritter, Eva Loffredo-Verde, Holger Garn, Tim Sparwasser, Clarissa Prazeres da Costa

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Human Lung Organoids—A Novel Experimental and Precision Medicine Approach by Laura Kühl, Pauline Graichen, Nele von Daacke, Anne Mende, Malgorzata Wygrecka, Daniel P. Potaczek, Sarah Miethe, Holger Garn

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Glutaredoxin 2 Reduces Asthma-Like Acute Airway Inflammation in Mice by Eva-Maria Hanschmann, Carsten Berndt, Christina Hecker, Holger Garn, W. Bertrams, Christopher H. Lillig, Christoph Hudemann, Christoph Hudemann

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A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma. by Jennifer Gossmann, Manfred Stolte, Michael Lohoff, Philipp Yu, Roland Moll, Florian Finkernagel, Holger Garn, Cornelia Brendel, Alwina Bittner, Andreas Neubauer, Minh Q Huynh

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IL-17 and TNF-α Are Key Mediators of Moraxella catarrhalis Triggered Exacerbation of Allergic Airway Inflammation by Safa Alnahas, Stefanie Hagner, Hartmann Raifer, Ayse Kilic, Georg Gasteiger, Reinier Mutters, Anne Hellhund, Immo Prinz, Olaf Pinkenburg, Alexander Visekruna, Holger Garn, Ulrich Steinhoff

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Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model by Yiwen Yao, Felix Ritzmann, Sarah Miethe, Kathrin Kattler-Lackes, Betül Colakoglu, Christian Herr, Andreas Kamyschnikow, Michelle Brand, Holger Garn, Daniela Yildiz, Frank Langer, Robert Bals, Christoph Beisswenger

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Side-Directed Release of Differential Extracellular Vesicle-associated microRNA Profiles from Bronchial Epithelial Cells of Healthy and Asthmatic Subjects by Viktoria E. M. Schindler, Fahd Alhamdan, Christian Preußer, Lukas Hintz, Bilal Alashkar Alhamwe, Andrea Nist, Thorsten Stiewe, Elke Pogge von Strandmann, Daniel P. Potaczek, Clemens Thölken, Holger Garn

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Timing of Blood Sample Processing Affects the Transcriptomic and Epigenomic Profiles in CD4⁺ T-cells of Atopic Subjects by Fahd Alhamdan, Kristina Laubhahn, Christine Happle, Anika Habener, Adan C. Jirmo, Clemens Thölken, Raffaele Conca, Ho-Ryun Chung, Gesine Hansen, Daniel P. Potaczek, Bianca Schaub, Ruth Grychtol, Holger Garn

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A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial by Timm Greulich, Jens M. Hohlfeld, Petra Neuser, Katrin Lueer, Andreas Klemmer, Carmen Schade-Brittinger, Susanne Harnisch, Holger Garn, Harald Renz, Ursula Homburg, Jonas Renz, Anne Kirsten, Frauke Pedersen, Meike Müller, Claus F. Vogelmeier, Henrik Watz

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Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4 by Lucia Campos Carrascosa, Matthias Klein, Yohko Kitagawa, Christina Lückel, Federico Marini, Anika König, Anna Guralnik, Hartmann Raifer, Stefanie Hagner-Benes, Diana Rädler, Andreas Böck, Cholho Kang, Michael Lohoff, Holger Garn, Bianca Schaub, Friederike Berberich-Siebelt, Shimon Sakaguchi, Tobias Bopp, Magdalena Huber

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Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis‐associated adhesion of ovarian cancer cells by Felix Neuhaus, Sonja Lieber, Veronika Shinkevich, Anna Mary Steitz, Hartmann Raifer, Kathrin Roth, Florian Finkernagel, Thomas Worzfeld, Andreas Burchert, Corinna Keber, Andrea Nist, Thorsten Stiewe, Silke Reinartz, Vanessa M. Beutgen, Johannes Graumann, Kim Pauck, Holger Garn, Matthias Gaida, Rolf Müller, Magdalena Huber

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Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways by Christina Wagner, Karin Uliczka, Judith Bossen, Xiao Niu, Christine Fink, Marcus Thiedmann, Mirjam Knop, Christina Vock, Ahmed Abdelsadik, Ulrich M. Zissler, Kerstin Isermann, Holger Garn, Mario Pieper, Michael Wegmann, Andreas R. Koczulla, Claus F. Vogelmeier, Carsten B. Schmidt-Weber, Heinz Fehrenbach, Peter König, Neil Silverman, Harald Renz, Petra Pfefferle, Holger Heine, Thomas Roeder

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