Human and Mouse Gastrointestinal Tumor Distribution is Selected According to a Basal Wnt Signalling Gradient অনুযায়ী Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffery, R, Rodriguez-Justo, M, Clark, S, East, J, Travis, S, Tomlinson, I, Leedham, S

HUMAN AND MOUSE GASTROINTESTINAL TUMOUR DISTRIBUTION IS SELECTED ACCORDING TO A BASAL INTESTINAL WNT SIGNALLING GRADIENT অনুযায়ী Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffry, R, Rodriguez-Justo, M, East, J, Travis, S, Clark, S, Tomlinson, I, Leedham, S

Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. অনুযায়ী Will, O, Carvajal-Carmona, L, Gorman, P, Howarth, K, Jones, A, Polanco-Echeverry, G, Chinaleong, J, Günther, T, Silver, A, Clark, S, Tomlinson, I

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations. অনুযায়ী Thirlwell, C, Howarth, K, Segditsas, S, Guerra, G, Thomas, H, Phillips, R, Talbot, I, Gorman, M, Novelli, MR, Sieber, O, Tomlinson, I

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. অনুযায়ী Svensson, L, Howarth, K, McDowall, A, Patzak, I, Evans, R, Ussar, S, Moser, M, Metin, A, Fried, M, Tomlinson, I, Hogg, N

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas. অনুযায়ী Jones, A, Thirlwell, C, Howarth, K, Graham, T, Chambers, W, Segditsas, S, Page, K, Phillips, R, Thomas, H, Sieber, O, Sawyer, E, Tomlinson, I

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. অনুযায়ী Carvajal-Carmona, L, Zauber, A, Jones, A, Howarth, K, Wang, J, Cheng, T, Riddell, R, Lanas, A, Morton, D, Bertagnolli, M, Tomlinson, I

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? অনুযায়ী Chow, E, Lipton, L, Carvajal-Carmona, L, Arthur, G, Bhathal, P, Kaur, G, Jaeger, E, Woodford-Richens, K, Howarth, K, Tomlinson, I, Macrae, F

A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk অনুযায়ী Howarth, K, Ranta, S, Winter, E, Teixeira, A, Schaschl, H, Harvey, J, Rowan, A, Jones, A, Spain, S, Clark, S, Guenther, T, Stewart, A, Silver, A, Tomlinson, I

APC and the three-hit hypothesis. অনুযায়ী Segditsas, S, Rowan, A, Howarth, K, Jones, A, Leedham, S, Wright, N, Gorman, P, Chambers, W, Domingo, E, Roylance, R, Sawyer, E, Sieber, O, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. অনুযায়ী Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instab... অনুযায়ী Gaasenbeek, M, Howarth, K, Rowan, A, Gorman, P, Jones, A, Chaplin, T, Liu, Y, Bicknell, D, Davison, E, Fiegler, H, Carter, N, Roylance, R, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts অনুযায়ী Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 অনুযায়ী Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer. অনুযায়ী Church, D, Briggs, SE, Palles, C, Domingo, E, Kearsey, S, Grimes, J, Gorman, M, Martin, L, Howarth, K, Hodgson, S, NSECG Collaborators, Kaur, K, Taylor, J, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. অনুযায়ী Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres অনুযায়ী Jones, A, Beggs, A, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG, Tomlinson, I

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. অনুযায়ী Jones, A, Beggs, A, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG, Tomlinson, I

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. অনুযায়ী Sieber, O, Howarth, K, Thirlwell, C, Rowan, A, Mandir, N, Goodlad, R, Gilkar, A, Spencer-Dene, B, Stamp, G, Johnson, V, Silver, A, Yang, H, Miller, J, Ilyas, M, Tomlinson, I

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. অনুযায়ী Pollard, P, Spencer-Dene, B, Shukla, D, Howarth, K, Nye, E, El-Bahrawy, M, Deheragoda, M, Joannou, M, McDonald, S, Martin, A, Igarashi, P, Varsani-Brown, S, Rosewell, I, Poulsom, R, Maxwell, P, Stamp, G, Tomlinson, I