Human and Mouse Gastrointestinal Tumor Distribution is Selected According to a Basal Wnt Signalling Gradient av Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffery, R, Rodriguez-Justo, M, Clark, S, East, J, Travis, S, Tomlinson, I, Leedham, S

HUMAN AND MOUSE GASTROINTESTINAL TUMOUR DISTRIBUTION IS SELECTED ACCORDING TO A BASAL INTESTINAL WNT SIGNALLING GRADIENT av Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffry, R, Rodriguez-Justo, M, East, J, Travis, S, Clark, S, Tomlinson, I, Leedham, S

Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. av Will, O, Carvajal-Carmona, L, Gorman, P, Howarth, K, Jones, A, Polanco-Echeverry, G, Chinaleong, J, Günther, T, Silver, A, Clark, S, Tomlinson, I

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations. av Thirlwell, C, Howarth, K, Segditsas, S, Guerra, G, Thomas, H, Phillips, R, Talbot, I, Gorman, M, Novelli, MR, Sieber, O, Tomlinson, I

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. av Svensson, L, Howarth, K, McDowall, A, Patzak, I, Evans, R, Ussar, S, Moser, M, Metin, A, Fried, M, Tomlinson, I, Hogg, N

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas. av Jones, A, Thirlwell, C, Howarth, K, Graham, T, Chambers, W, Segditsas, S, Page, K, Phillips, R, Thomas, H, Sieber, O, Sawyer, E, Tomlinson, I

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. av Carvajal-Carmona, L, Zauber, A, Jones, A, Howarth, K, Wang, J, Cheng, T, Riddell, R, Lanas, A, Morton, D, Bertagnolli, M, Tomlinson, I

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? av Chow, E, Lipton, L, Carvajal-Carmona, L, Arthur, G, Bhathal, P, Kaur, G, Jaeger, E, Woodford-Richens, K, Howarth, K, Tomlinson, I, Macrae, F

A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk av Howarth, K, Ranta, S, Winter, E, Teixeira, A, Schaschl, H, Harvey, J, Rowan, A, Jones, A, Spain, S, Clark, S, Guenther, T, Stewart, A, Silver, A, Tomlinson, I

APC and the three-hit hypothesis. av Segditsas, S, Rowan, A, Howarth, K, Jones, A, Leedham, S, Wright, N, Gorman, P, Chambers, W, Domingo, E, Roylance, R, Sawyer, E, Sieber, O, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. av Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instab... av Gaasenbeek, M, Howarth, K, Rowan, A, Gorman, P, Jones, A, Chaplin, T, Liu, Y, Bicknell, D, Davison, E, Fiegler, H, Carter, N, Roylance, R, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts av Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 av Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer. av Church, D, Briggs, SE, Palles, C, Domingo, E, Kearsey, S, Grimes, J, Gorman, M, Martin, L, Howarth, K, Hodgson, S, NSECG Collaborators, Kaur, K, Taylor, J, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. av Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres av Jones, A, Beggs, A, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG, Tomlinson, I

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. av Jones, A, Beggs, A, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG, Tomlinson, I

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. av Sieber, O, Howarth, K, Thirlwell, C, Rowan, A, Mandir, N, Goodlad, R, Gilkar, A, Spencer-Dene, B, Stamp, G, Johnson, V, Silver, A, Yang, H, Miller, J, Ilyas, M, Tomlinson, I

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. av Pollard, P, Spencer-Dene, B, Shukla, D, Howarth, K, Nye, E, El-Bahrawy, M, Deheragoda, M, Joannou, M, McDonald, S, Martin, A, Igarashi, P, Varsani-Brown, S, Rosewell, I, Poulsom, R, Maxwell, P, Stamp, G, Tomlinson, I