Human and Mouse Gastrointestinal Tumor Distribution is Selected According to a Basal Wnt Signalling Gradient 由 Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffery, R, Rodriguez-Justo, M, Clark, S, East, J, Travis, S, Tomlinson, I, Leedham, S

HUMAN AND MOUSE GASTROINTESTINAL TUMOUR DISTRIBUTION IS SELECTED ACCORDING TO A BASAL INTESTINAL WNT SIGNALLING GRADIENT 由 Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Jeffry, R, Rodriguez-Justo, M, East, J, Travis, S, Clark, S, Tomlinson, I, Leedham, S

Homozygous PMS2 deletion causes a severe colorectal cancer and multiple adenoma phenotype without extraintestinal cancer. 由 Will, O, Carvajal-Carmona, L, Gorman, P, Howarth, K, Jones, A, Polanco-Echeverry, G, Chinaleong, J, Günther, T, Silver, A, Clark, S, Tomlinson, I

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations. 由 Thirlwell, C, Howarth, K, Segditsas, S, Guerra, G, Thomas, H, Phillips, R, Talbot, I, Gorman, M, Novelli, MR, Sieber, O, Tomlinson, I

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. 由 Svensson, L, Howarth, K, McDowall, A, Patzak, I, Evans, R, Ussar, S, Moser, M, Metin, A, Fried, M, Tomlinson, I, Hogg, N

Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas. 由 Jones, A, Thirlwell, C, Howarth, K, Graham, T, Chambers, W, Segditsas, S, Page, K, Phillips, R, Thomas, H, Sieber, O, Sawyer, E, Tomlinson, I

Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. 由 Carvajal-Carmona, L, Zauber, A, Jones, A, Howarth, K, Wang, J, Cheng, T, Riddell, R, Lanas, A, Morton, D, Bertagnolli, M, Tomlinson, I

A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? 由 Chow, E, Lipton, L, Carvajal-Carmona, L, Arthur, G, Bhathal, P, Kaur, G, Jaeger, E, Woodford-Richens, K, Howarth, K, Tomlinson, I, Macrae, F

A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk 由 Howarth, K, Ranta, S, Winter, E, Teixeira, A, Schaschl, H, Harvey, J, Rowan, A, Jones, A, Spain, S, Clark, S, Guenther, T, Stewart, A, Silver, A, Tomlinson, I

APC and the three-hit hypothesis. 由 Segditsas, S, Rowan, A, Howarth, K, Jones, A, Leedham, S, Wright, N, Gorman, P, Chambers, W, Domingo, E, Roylance, R, Sawyer, E, Sieber, O, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts. 由 Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instab... 由 Gaasenbeek, M, Howarth, K, Rowan, A, Gorman, P, Jones, A, Chaplin, T, Liu, Y, Bicknell, D, Davison, E, Fiegler, H, Carter, N, Roylance, R, Tomlinson, I

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts 由 Leedham, S, Rodenas-Cuadrado, P, Howarth, K, Lewis, A, Mallappa, S, Segditsas, S, Davis, H, Jeffery, R, Rodriguez-Justo, M, Keshav, S, Travis, S, Graham, T, East, J, Clark, S, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 由 Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer. 由 Church, D, Briggs, SE, Palles, C, Domingo, E, Kearsey, S, Grimes, J, Gorman, M, Martin, L, Howarth, K, Hodgson, S, NSECG Collaborators, Kaur, K, Taylor, J, Tomlinson, I

Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. 由 Jaeger, E, Leedham, S, Lewis, A, Segditsas, S, Becker, M, Cuadrado, P, Davis, H, Kaur, K, Heinimann, K, Howarth, K, East, J, Taylor, J, Thomas, H, Tomlinson, I

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres 由 Jones, A, Beggs, A, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG, Tomlinson, I

TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres. 由 Jones, A, Beggs, A, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, MG, Tomlinson, I

Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. 由 Sieber, O, Howarth, K, Thirlwell, C, Rowan, A, Mandir, N, Goodlad, R, Gilkar, A, Spencer-Dene, B, Stamp, G, Johnson, V, Silver, A, Yang, H, Miller, J, Ilyas, M, Tomlinson, I

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. 由 Pollard, P, Spencer-Dene, B, Shukla, D, Howarth, K, Nye, E, El-Bahrawy, M, Deheragoda, M, Joannou, M, McDonald, S, Martin, A, Igarashi, P, Varsani-Brown, S, Rosewell, I, Poulsom, R, Maxwell, P, Stamp, G, Tomlinson, I