A medical record-linked biorepository to identify novel biomarkers for atherosclerotic cardiovascular disease by Zi Ye, Fara S Kalloo, Iftikhar J Kullo

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Risk Factors for Polyvascular Involvement in Patients With Peripheral Artery Disease: A Mendelian Randomization Study by Ozan Dikilitas, Benjamin A. Satterfield, Iftikhar J. Kullo

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Deep generative models of LDLR protein structure to predict variant pathogenicity by Jose K. James, Kristjan Norland, Angad S. Johar, Iftikhar J. Kullo

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Examining the Impact of Polygenic Risk Information in Primary Care by Joel E. Pacyna, Jackson S. Ennis, Iftikhar J. Kullo, Richard R. Sharp

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Web-Based Tool (FH Family Share) to Increase Uptake of Cascade Testing for Familial Hypercholesterolemia: Development and Evaluation by Hana Bangash, Ahmed Makkawy, Justin H Gundelach, Alexandra A Miller, Kimberly A Jacobson, Iftikhar J Kullo

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Rare loss-of-function variants in matrisome genes are enriched in Ebstein’s anomaly by Zhou Zhou, Xia Tang, Wen Chen, Qianlong Chen, Bo Ye, Angad S. Johar, Iftikhar J. Kullo, Keyue Ding

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The burden of severe hypercholesterolemia and familial hypercholesterolemia in a population-based setting in the US by Seyedmohammad Saadatagah, Lubna Alhalabi, Medhat Farwati, Magdi Zordok, Ashwini Bhat, Carin Y. Smith, Christina M. Wood-Wentz, Kent R. Bailey, Iftikhar J. Kullo

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Quantitative disease risk scores from EHR with applications to clinical risk stratification and genetic studies by Danqing Xu, Chen Wang, Atlas Khan, Ning Shang, Zihuai He, Adam Gordon, Iftikhar J. Kullo, Shawn Murphy, Yizhao Ni, Wei-Qi Wei, Ali Gharavi, Krzysztof Kiryluk, Chunhua Weng, Iuliana Ionita-Laza

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Transgelin: a new gene involved in LDL endocytosis identified by a genome-wide CRISPR-Cas9 screen by Diego Lucero, Ozan Dikilitas, Michael M. Mendelson, Zahra Aligabi, Promotto Islam, Edward B. Neufeld, Aruna T. Bansal, Lita A. Freeman, Boris Vaisman, Jingrong Tang, Christian A. Combs, Yuesheng Li, Szilard Voros, Iftikhar J. Kullo, Alan T. Remaley

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Genetic predictors of blood pressure traits are associated with preeclampsia by Elizabeth A. Jasper, Jacklyn N. Hellwege, Joseph H. Breeyear, Brenda Xiao, Gail P. Jarvik, Ian B. Stanaway, Kathleen A. Leppig, Geetha Chittoor, M. Geoffrey Hayes, Ozan Dikilitas, Iftikhar J. Kullo, Ingrid A. Holm, Shefali Setia Verma, Todd L. Edwards, Digna R. Velez Edwards

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Effect of clinical decision support for severe hypercholesterolemia on low-density lipoprotein cholesterol levels by Hana Bangash, Seyedmohammad Saadatagah, Mohammadreza Naderian, Marwan E. Hamed, Lubna Alhalabi, Alborz Sherafati, Joseph Sutton, Omar Elsekaily, Ali Mir, Justin H. Gundelach, Daniel Gibbons, Paul Johnsen, Christina M. Wood-Wentz, Carin Y. Smith, Pedro J. Caraballo, Kent R. Bailey, Iftikhar J. Kullo

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Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms by Milton Pividori, Sumei Lu, Binglan Li, Chun Su, Matthew E. Johnson, Wei-Qi Wei, Qiping Feng, Bahram Namjou, Krzysztof Kiryluk, Iftikhar J. Kullo, Yuan Luo, Blair D. Sullivan, Benjamin F. Voight, Carsten Skarke, Marylyn D. Ritchie, Struan F. A. Grant, eMERGE Consortium, Casey S. Greene

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Leveraging the Electronic Health Record to Create an Automated Real‐Time Prognostic Tool for Peripheral Arterial Disease by Adelaide M. Arruda‐Olson, Naveed Afzal, Vishnu Priya Mallipeddi, Ahmad Said, Homam Moussa Pacha, Sungrim Moon, Alisha P. Chaudhry, Christopher G. Scott, Kent R. Bailey, Thom W. Rooke, Paul W. Wennberg, Vinod C. Kaggal, Gustavo S. Oderich, Iftikhar J. Kullo, Rick A. Nishimura, Rajeev Chaudhry, Hongfang Liu

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Promise and Peril of a Genotype‐First Approach to Mendelian Cardiovascular Disease by Babken Asatryan, Brittney Murray, Rafik Tadros, Marina Rieder, Ravi A. Shah, Ghaith Sharaf Dabbagh, Andrew P. Landstrom, Stephan Dobner, Patricia B. Munroe, Christopher M. Haggerty, Argelia Medeiros‐Domingo, Anjali T. Owens, Iftikhar J. Kullo, Christopher Semsarian, Tobias Reichlin, Andreas S. Barth, Dan M. Roden, Cynthia A. James, James S. Ware, C. Anwar A. Chahal

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Risk factors affecting polygenic score performance across diverse cohorts by Daniel Hui, Scott Dudek, Krzysztof Kiryluk, Theresa L Walunas, Iftikhar J Kullo, Wei-Qi Wei, Hemant Tiwari, Josh F Peterson, Wendy K Chung, Brittney H Davis, Atlas Khan, Leah C Kottyan, Nita A Limdi, Qiping Feng, Megan J Puckelwartz, Chunhua Weng, Johanna L Smith, Elizabeth W Karlson, Regeneron Genetics Center, Penn Medicine BioBank, Gail P Jarvik, Marylyn D Ritchie

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Author Correction: Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection by Kathleen Ferar, Taryn O. Hall, Dana C. Crawford, Robb Rowley, Benjamin A. Satterfield, Rongling Li, Loren Gragert, Elizabeth W. Karlson, Mariza de Andrade, Iftikhar J. Kullo, Catherine A. McCarty, Abel Kho, M. Geoffrey Hayes, Marylyn D. Ritchie, Paul K. Crane, Daniel B. Mirel, Christopher Carlson, John J. Connolly, Hakon Hakonarson, Andrew T. Crenshaw, David Carrell, Yuan Luo, Ozan Dikilitas, Joshua C. Denny, Gail P. Jarvik, David R. Crosslin

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Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection by Kathleen Ferar, Taryn O. Hall, Dana C. Crawford, Robb Rowley, Benjamin A. Satterfield, Rongling Li, Loren Gragert, Elizabeth W. Karlson, Mariza de Andrade, Iftikhar J. Kullo, Catherine A. McCarty, Abel Kho, M. Geoffrey Hayes, Marylyn D. Ritchie, Paul K. Crane, Daniel B. Mirel, Christopher Carlson, John J. Connolly, Hakon Hakonarson, Andrew T. Crenshaw, David Carrell, Yuan Luo, Ozan Dikilitas, Joshua C. Denny, Gail P. Jarvik, David R. Crosslin

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Clinical associations with a polygenic predisposition to benign lower white blood cell counts by Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson, Jacy Zanussi, Laura L. Daniel, Neil S. Zheng, Lisa Bastarache, Wei-Qi Wei, Mingjian Shi, Gail P. Jarvik, Elisabeth A. Rosenthal, Atlas Khan, Alborz Sherafati, Iftikhar J. Kullo, Theresa L. Walunas, Joseph Glessner, Hakon Hakonarson, Nancy J. Cox, Dan M. Roden, Stephan G. Frangakis, Brett Vanderwerff, C. Michael Stein, Sara L. Van Driest, Scott C. Borinstein, Xiao-Ou Shu, Matthew Zawistowski, Cecilia P. Chung, Vivian K. Kawai

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Evaluation of the portability of computable phenotypes with natural language processing in the eMERGE network by Jennifer A. Pacheco, Luke V. Rasmussen, Ken Wiley, Thomas Nate Person, David J. Cronkite, Sunghwan Sohn, Shawn Murphy, Justin H. Gundelach, Vivian Gainer, Victor M. Castro, Cong Liu, Frank Mentch, Todd Lingren, Agnes S. Sundaresan, Garrett Eickelberg, Valerie Willis, Al’ona Furmanchuk, Roshan Patel, David S. Carrell, Yu Deng, Nephi Walton, Benjamin A. Satterfield, Iftikhar J. Kullo, Ozan Dikilitas, Joshua C. Smith, Josh F. Peterson, Ning Shang, Krzysztof Kiryluk, Yizhao Ni, Yikuan Li, Girish N. Nadkarni, Elisabeth A. Rosenthal, Theresa L. Walunas, Marc S. Williams, Elizabeth W. Karlson, Jodell E. Linder, Yuan Luo, Chunhua Weng, WeiQi Wei

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Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease by Yask Gupta, David J. Friedman, Michelle T. McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L. Knob, Tze Y. Lim, Gerald B. Appel, Kinsie Huggins, Lili Liu, Adele Mitrotti, Megan C. Stangl, Andrew Bomback, Rik Westland, Monica Bodria, Maddalena Marasa, Ning Shang, David J. Cohen, Russell J. Crew, William Morello, Pietro Canetta, Jai Radhakrishnan, Jeremiah Martino, Qingxue Liu, Wendy K. Chung, Angelica Espinoza, Yuan Luo, Wei-Qi Wei, Qiping Feng, Chunhua Weng, Yilu Fang, Iftikhar J. Kullo, Mohammadreza Naderian, Nita Limdi, Marguerite R. Irvin, Hemant Tiwari, Sumit Mohan, Maya Rao, Geoffrey K. Dube, Ninad S. Chaudhary, Orlando M. Gutiérrez, Suzanne E. Judd, Mary Cushman, Leslie A. Lange, Ethan M. Lange, Daniel L. Bivona, Miguel Verbitsky, Cheryl A. Winkler, Jeffrey B. Kopp, Dominick Santoriello, Ibrahim Batal, Sérgio Veloso Brant Pinheiro, Eduardo Araújo Oliveira, Ana Cristina Simoes e Silva, Isabella Pisani, Enrico Fiaccadori, Fangming Lin, Loreto Gesualdo, Antonio Amoroso, Gian Marco Ghiggeri, Vivette D. D’Agati, Riccardo Magistroni, Eimear E. Kenny, Ruth J. F. Loos, Giovanni Montini, Friedhelm Hildebrandt, Dirk S. Paul, Slavé Petrovski, David B. Goldstein, Matthias Kretzler, Rasheed Gbadegesin, Ali G. Gharavi, Krzysztof Kiryluk, Matthew G. Sampson, Martin R. Pollak, Simone Sanna-Cherchi

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