Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. by Igor E Brodsky, Ruslan Medzhitov

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Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human cells by Jenna Zhang, Igor E. Brodsky, Sunny Shin

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TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts Legionella pneumophila infection. by Tzvi Y Pollock, Víctor R Vázquez Marrero, Igor E Brodsky, Sunny Shin

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Cryptosporidium impacts epithelial turnover and is resistant to induced death of the host cell by Bethan A. Wallbank, Ryan D. Pardy, Igor E. Brodsky, Christopher A. Hunter, Boris Striepen

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A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. by Ying Zheng, Sarit Lilo, Igor E Brodsky, Yue Zhang, Ruslan Medzhitov, Kenneth B Marcu, James B Bliska

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Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity. by Adriana R Mantegazza, Meghan A Wynosky-Dolfi, Cierra N Casson, Ariel J Lefkovith, Sunny Shin, Igor E Brodsky, Michael S Marks

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IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by <named-content content-type="genus-species">Yersinia pestis</named-content> Type III Effector YopM by Lawton K. Chung, Naomi H. Philip, Valentina A. Schmidt, Antonius Koller, Till Strowig, Richard A. Flavell, Igor E. Brodsky, James B. Bliska

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CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production. by Fernanda O Novais, Augusto M Carvalho, Megan L Clark, Lucas P Carvalho, Daniel P Beiting, Igor E Brodsky, Edgar M Carvalho, Phillip Scott

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Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD by Erin E. Zwack, Annelise G. Snyder, Meghan A. Wynosky-Dolfi, Gordon Ruthel, Naomi H. Philip, Melanie M. Marketon, Matthew S. Francis, James B. Bliska, Igor E. Brodsky

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Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS by Daniel C Akuma, Kimberly A Wodzanowski, Ronit Schwartz Wertman, Patrick M Exconde, Víctor R Vázquez Marrero, Chukwuma E Odunze, Daniel Grubaugh, Sunny Shin, Cornelius Taabazuing, Igor E Brodsky

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Caspase-11 activation in response to bacterial secretion systems that access the host cytosol. by Cierra N Casson, Alan M Copenhaver, Erin E Zwack, Hieu T Nguyen, Till Strowig, Bahar Javdan, William P Bradley, Thomas C Fung, Richard A Flavell, Igor E Brodsky, Sunny Shin

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Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation by Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand

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Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death. by Naomi H Philip, Alexandra DeLaney, Lance W Peterson, Melanie Santos-Marrero, Jennifer T Grier, Yan Sun, Meghan A Wynosky-Dolfi, Erin E Zwack, Baofeng Hu, Tayla M Olsen, Anthony Rongvaux, Scott D Pope, Carolina B López, Andrew Oberst, Daniel P Beiting, Jorge Henao-Mejia, Igor E Brodsky

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