Revisiting the role of insulin-like growth factor-I receptor stimulating activity and the apolipoprotein E in Alzheimer’s disease od Galle, SA, Van Der Spek, A, Drent, ML, Brugts, MP, Scherder, EJA, Janssen, JAMJL, Ikram, MA, Van Duijn, CM

Thyroid function and atrial fibrillation: Is there a mediating role for epicardial adipose tissue? od Bos D, Bano A, Hofman A, VanderWeele TJ, Kavousi M, Franco OH, Vernooij MW, Peeters RP, Ikram MA, Chaker L

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Prion protein codon 129 polymorphism in mild cognitive impairment and dementia: the Rotterdam Study od Karamujić-Čomić, H, Ahmad, S, Lysen, TS, Heshmatollah, A, Roshchupkin, GV, Vernooij, MW, Rozemuller, AJM, Ikram, MA, Amin, N, van Duijn, CM

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia od Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

A comprehensive study of genetic regulation and disease associations of plasma circulatory microRNAs using population-level data od Mustafa, R, Mens, MMJ, van Hilten, A, Huang, J, Roshchupkin, G, Huan, T, Broer, L, van Meurs, JBJ, Elliott, P, Levy, D, Ikram, MA, Evangelou, M, Dehghan, A, Ghanbari, M

Circulating metabolites are associated with brain atrophy and white matter hyperintensities od de Leeuw, FA, Karamujić-Čomić, H, Tijms, BM, Peeters, CFW, Kester, MI, Scheltens, P, Ahmad, S, Vojinovic, D, Adams, HHH, Hankemeier, T, Bos, D, van der Lugt, A, Vernooij, MW, Ikram, MA, Amin, N, Barkhof, F, Teunissen, CE, van Duijn, CM, van der Flier, WM

CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers od Ahmad, S, del Campo Milan, M, Hansson, O, Demirkan, A, Agustin, R, Sáez, ME, Giagtzoglou, N, Cabrera-Socorro, A, Bakker, MHM, Ramirez, A, Hankemeier, T, Stomrud, E, Mattsson-Carlgren, N, Scheltens, P, van der Flier, WM, Ikram, MA, Malarstig, A, Teunissen, CE, Amin, N, van Duijn, CM

Exome sequencing analysis identifies rare variants in ATM and RPL8 that are associated with shorter telomere length od van der Spek, A, Warner, SC, Broer, L, Nelson, CP, Vojinovic, D, Ahmad, S, Arp, PP, Brouwer, RWW, Denniff, M, van den Hout, MCGN, van Rooij, JGJ, Kraaij, R, van IJcken, WFJ, Samani, NJ, Ikram, MA, Uitterlinden, AG, Codd, V, Amin, N, van Duijn, CM

Interplay of the human exposome, metabolome and gut microbiome in dementia and major depression od van Duijn, CM, Amin, N, Liu, J, Bonnechere, B, MahmoudianDehkordi, S, Arnold, M, Batra, R, Chiou, YJ, Fernandes, M, Ikram, MA, Kraaij, R, Krumsiek, J, Newby, D, Shi, L, Nho, K, Radjabzadeh, D, Saykin, AJ, Sproviero, W, Winchester, LM, Yang, Y, Nevado-Holgado, AJ, Kastenmüller, G, Kaddurah-Daouk, R

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multicohort multivariable regression and Mendelian randomization analyses od Bos, MM, Goulding, NJ, Lee, MA, Hofman, A, Bot, M, Pool, R, Vijfhuizen, LS, Zhang, X, Li, C, Mustafa, R, Neville, M, Li-Gao, R, Trompet, S, Beekman, M, Biermasz, NR, Boomsma, DI, de Boer, I, Christodoulides, C, Dehghan, A, Willems van Dijk, K, Ford, I, Ghanbari, M, Heijmans, BT, Ikram, MA, Jukema, JW, Mook-Kanamori, DO, Karpe, F

Intima-media thickness at the near or far wall of the common carotid artery in cardiovascular risk assessment od Seekircher, L, Tschiderer, L, Lind, L, Safarova, MS, Kavousi, M, Ikram, MA, Lonn, E, Yusuf, S, Grobbee, DE, Kastelein, JJP, Visseren, FLJ, Walters, M, Dawson, J, Higgins, P, Agewall, S, Catapano, A, de Groot, E, Espeland, MA, Klingenschmid, G, Magliano, D, Olsen, MH, Preiss, D, Sander, D, Skilton, M, Zozulińska-Ziółkiewicz, DA, Grooteman, MPC, Blankestijn, PJ, Kitagawa, K, Okazaki, S, Manzi, MV, Mancusi, C, Izzo, R, Desvarieux, M, Rundek, T, Gerstein, HC, Bots, ML, Sweeting, MJ, Lorenz, MW, Willeit, P

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine od Onderwater, GLJ, Ligthart, L, Bot, M, Demirkan, A, Fu, J, Van Der Kallen, CJH, Vijfhuizen, LS, Pool, R, Liu, J, Vanmolkot, FHM, Beekman, M, Wen, K-X, Amin, N, Thesing, CS, Pijpers, JA, Kies, DA, Zielman, R, De Boer, I, Van Greevenbroek, MMJ, Arts, ICW, Milaneschi, Y, Schram, MT, Dagnelie, PC, Franke, L, Ikram, MA, Ferrari, MD, Goeman, JJ, Slagboom, PE, Wijmenga, C, Stehouwer, CDA, Boomsma, DI, Van Duijn, CM, Penninx, BW, Hoen, PAC, Terwindt, GM, Van Den Maagdenberg, AMJM, Bbmri Metabolomics Consortium

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways od Duffy, DL, Zhu, G, Li, X, Sanna, M, Iles, MM, Jacobs, LC, Evans, DM, Yazar, S, Beesley, J, Law, MH, Kraft, P, Visconti, A, Taylor, JC, Liu, F, Wright, MJ, Henders, AK, Bowdler, L, Glass, D, Ikram, MA, Uitterlinden, AG, Madden, PA, Heath, AC, Nelson, EC, Green, AC, Chanock, S, Barrett, JH, Brown, MA, Hayward, NK, Macgregor, S, Sturm, RA, Hewitt, AW, Kayser, M, Hunter, DJ, Newton Bishop, JA, Spector, TD, Montgomery, GW, Mackey, DA, Smith, GD, Nijsten, TE, Bishop, DT, Bataille, V, Falchi, M, Han, J, Martin, NG

Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling. od van Vliet, NA, Bos, MM, Thesing, CS, Chaker, L, Pietzner, M, Houtman, E, Neville, MJ, Li-Gao, R, Trompet, S, Mustafa, R, Ahmadizar, F, Beekman, M, Bot, M, Budde, K, Christodoulides, C, Dehghan, A, Delles, C, Elliott, P, Evangelou, M, Gao, H, Ghanbari, M, van Herwaarden, AE, Ikram, MA, Jaeger, M, Jukema, JW, Karaman, I, Karpe, F, Kloppenburg, M, Meessen, JMTA, Meulenbelt, I, Milaneschi, Y, Mooijaart, SP, Mook-Kanamori, DO, Netea, MG, Netea-Maier, RT, Peeters, RP, Penninx, BWJH, Sattar, N, Slagboom, PE, Suchiman, HED, Völzke, H, Willems van Dijk, K, Noordam, R, van Heemst, D

Metabolic age based on the BBMRI-NL 1H-NMR metabolomics repository as biomarker of age-related disease od van den Akker, EB, Trompet, S, Barkey Wolf, JJH, Beekman, M, Suchiman, HED, Deelen, J, Asselbergs, FW, Boersma, E, Cats, D, Elders, PM, Geleijnse, JM, Ikram, MA, Kloppenburg, M, Mei, H, Meulenbelt, I, Mooijaart, SP, Nelissen, RGHH, Netea, MG, Penninx, BWJH, Slofstra, M, Stehouwer, CDA, Swertz, MA, Teunissen, CE, Terwindt, GM, 't Hart, LM, van den Maagdenberg, AMJM, van der Harst, P, van der Horst, ICC, van der Kallen, CJH, van Greevenbroek, MMJ, van Spil, WE, Wijmenga, C, Zhernakova, A, Zwinderman, AH, Sattar, N, Jukema, JW, Boomsma, DI, van Duijn, CM, Reinders, MJT, Slagboom, PE

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color od Simcoe, M, Valdes, A, Liu, F, Furlotte, NA, Evans, DM, Hemani, G, Ring, SM, Smith, GD, Duffy, DL, Zhu, G, Gordon, SD, Medland, SE, Vuckovic, D, Girotto, G, Sala, C, Catamo, E, Concas, MP, Brumat, M, Gasparini, P, Toniolo, D, Cocca, M, Robino, A, Yazar, S, Hewitt, A, Wu, W, Kraft, P, Hammond, CJ, Shi, Y, Chen, Y, Zeng, C, Klaver, CCW, Uitterlinden, AG, Ikram, MA, Hamer, MA, van Duijn, CM, Nijsten, T, Han, J, Mackey, DA, Martin, NG, Cheng, C-Y, 23andMe Research Team, International Visible Trait Genetics Consortium, Hinds, DA, Spector, TD, Kayser, M, Hysi, PG

Meta-analysis of epigenome-wide association studies of cognitive abilities od Marioni, RE, McRae, AF, Bressler, J, Colicino, E, Hannon, E, Li, S, Prada, D, Smith, JA, Trevisi, L, Tsai, P-C, Vojinovic, D, Simino, J, Levy, D, Liu, C, Mendelson, M, Satizabal, CL, Yang, Q, Jhun, MA, Kardia, SLR, Zhao, W, Bandinelli, S, Ferrucci, L, Hernandez, DG, Singleton, AB, Harris, SE, Starr, JM, Kiel, DP, McLean, RR, Just, AC, Schwartz, J, Spiro, A, Vokonas, P, Amin, N, Ikram, MA, Uitterlinden, AG, Van Meurs, JBJ, Spector, TD, Steves, C, Baccarelli, AA, Bell, JT, Van Duijn, CM, Fornage, M, Hsu, Y-H, Mill, J, Mosley, TH, Seshadri, S, Deary, IJ

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus od Mathieson, I, Day, FR, Barban, N, Tropf, FC, Brazel, DM, eQTLGen Consortium, BIOS Consortium, Vaez, A, van Zuydam, N, Bitarello, BD, Gardner, EJ, Akimova, ET, Azad, A, Bergmann, S, Bielak, LF, Boomsma, DI, Bosak, K, Brumat, M, Buring, JE, Cesarini, D, Chasman, DI, Chavarro, JE, Cocca, M, Concas, MP, Davey Smith, G, Davies, G, Deary, IJ, Esko, T, Faul, JD, FinnGen Study, Franco, O, Ganna, A, Gaskins, AJ, Gelemanovic, A, de Geus, EJC, Gieger, C, Girotto, G, Gopinath, B, Grabe, HJ, Gunderson, EP, Hayward, C, He, C, van Heemst, D, Hill, WD, Hoffmann, ER, Homuth, G, Hottenga, JJ, Huang, H, Hyppӧnen, E, Ikram, MA, Mills, MC

Genome-wide characterization of circulating metabolic biomarkers od Karjalainen, MK, Karthikeyan, S, Oliver-Williams, C, Sliz, E, Allara, E, Fung, WT, Surendran, P, Zhang, W, Jousilahti, P, Kristiansson, K, Salomaa, V, Goodwin, M, Hughes, DA, Boehnke, M, Fernandes Silva, L, Yin, X, Mahajan, A, Neville, MJ, van Zuydam, NR, de Mutsert, R, Li-Gao, R, Mook-Kanamori, DO, Demirkan, A, Liu, J, Noordam, R, Trompet, S, Chen, Z, Kartsonaki, C, Li, L, Lin, K, Hagenbeek, FA, Hottenga, JJ, Pool, R, Ikram, MA, van Meurs, J, Haller, T, Milaneschi, Y, Kähönen, M, Mishra, PP, Joshi, PK, Macdonald-Dunlop, E, Mangino, M, Zierer, J, Acar, IE, Hoyng, CB, Lechanteur, YTE, Franke, L, Kurilshikov, A, Zhernakova, A, Beekman, M, Walters, RG, Karpe, F, McCarthy, MI, van Duijn, C, Kettunen, J

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults od Hofer, E, Roshchupkin, GV, Adams, HHH, Knol, MJ, Lin, H, Li, S, Zare, H, Ahmad, S, Armstrong, NJ, Satizabal, CL, Bernard, M, Bis, JC, Gillespie, NA, Luciano, M, Mishra, A, Scholz, M, Teumer, A, Xia, R, Jian, X, Mosley, TH, Saba, Y, Pirpamer, L, Seiler, S, Becker, JT, Carmichael, O, Rotter, JI, Psaty, BM, Lopez, OL, Amin, N, van der Lee, SJ, Yang, Q, Himali, JJ, Maillard, P, Beiser, AS, DeCarli, C, Karama, S, Lewis, L, Harris, M, Bastin, ME, Deary, IJ, Veronica Witte, A, Beyer, F, Loeffler, M, Mather, KA, Schofield, PR, Thalamuthu, A, Kwok, JB, Wright, MJ, Ames, D, Trollor, J, van Duijn, CM, Grabe, HJ, Longstreth Jr, WT, Fornage, M, Paus, T, Debette, S, Ikram, MA, Schmidt, H, Schmidt, R, Seshadr, S