The effect of organ-specific tumor microenvironments on response patterns to immunotherapy by Jordan W. Conway, Jordan W. Conway, Jordan W. Conway, Jorja Braden, Jorja Braden, Jorja Braden, James S. Wilmott, James S. Wilmott, James S. Wilmott, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Georgina V. Long, Georgina V. Long, Georgina V. Long, Georgina V. Long, Georgina V. Long, Inês Pires da Silva, Inês Pires da Silva, Inês Pires da Silva, Inês Pires da Silva

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Causes, consequences and clinical significance of aneuploidy across melanoma subtypes by Eva R. Shteinman, Eva R. Shteinman, Eva R. Shteinman, James S. Wilmott, James S. Wilmott, James S. Wilmott, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Georgina V. Long, Georgina V. Long, Georgina V. Long, Georgina V. Long, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Ismael A. Vergara, Ismael A. Vergara, Ismael A. Vergara

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Immune Checkpoint Inhibitors +/− Chemotherapy for Patients With NSCLC and Brain Metastases: A Systematic Review and Network Meta‐Analysis by Lauren Julia Brown, Nicholas Yeo, Harriet Gee, Benjamin Y. Kong, Eric Hau, Inês Pires daSilva, Adnan Nagrial

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Five‐year survival and clinical correlates among patients with advanced non‐small cell lung cancer, melanoma and renal cell carcinoma treated with immune check‐point inhibitors in... by Lauren J Brown, Ines Pires da Silva, Tania Moujaber, Bo Gao, Rina Hui, Howard Gurney, Matteo Carlino, Adnan Nagrial

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82 Spatial immunophenotyping of longitudinal metastatic melanoma specimens to identify biomarkers of response and resistance to combination anti-LAG-3 + anti-PD-1-based immunothera... by Georgina V Long, Richard A Scolyer, Alexander M Menzies, James S Wilmott, Tuba N Gide, Yizhe Mao, Ella McCutcheon, Nigel Maher, Ping Shang, Ines Pires da Silva

Lag-3 expression and clinical outcomes in metastatic melanoma patients treated with combination anti-lag-3 + anti-PD-1-based immunotherapies by Tuba N. Gide, Elizabeth C. Paver, Zarwa Yaseen, Nigel Maher, Nurudeen Adegoke, Alexander M. Menzies, Ines Pires da Silva, James S. Wilmott, Georgina V. Long, Richard A. Scolyer

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Size matters: integrating tumour volume and immune activation signatures predicts immunotherapy response by Su Yin Lim, Ines Pires da Silva, Nurudeen A. Adegoke, Serigne N. Lo, Alexander M. Menzies, Matteo S. Carlino, Richard A. Scolyer, Georgina V. Long, Jenny H. Lee, Helen Rizos

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Detailed spatial immunophenotyping of primary melanomas reveals immune cell subpopulations associated with patient outcome by Grace H. Attrill, Grace H. Attrill, Grace H. Attrill, Hansol Lee, Hansol Lee, Hansol Lee, Annie T. Tasker, Annie T. Tasker, Annie T. Tasker, Nurudeen A. Adegoke, Nurudeen A. Adegoke, Nurudeen A. Adegoke, Angela L. Ferguson, Angela L. Ferguson, Angela L. Ferguson, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Robyn P. M. Saw, Robyn P. M. Saw, Robyn P. M. Saw, Robyn P. M. Saw, John F. Thompson, John F. Thompson, John F. Thompson, John F. Thompson, Umaimainthan Palendira, Umaimainthan Palendira, Umaimainthan Palendira, Umaimainthan Palendira, Georgina V. Long, Georgina V. Long, Georgina V. Long, Georgina V. Long, Georgina V. Long, Peter M. Ferguson, Peter M. Ferguson, Peter M. Ferguson, Peter M. Ferguson, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, Richard A. Scolyer, James S. Wilmott, James S. Wilmott, James S. Wilmott

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Classification of the tumor immune microenvironment and associations with outcomes in patients with metastatic melanoma treated with immunotherapies by Ines Pires da Silva, Richard A Scolyer, Georgina Long, Matteo S Carlino, Ismael A Vergara, James S Wilmott, Serigne N Lo, Tuba N Gide, Alexander Maxwell Menzies, Nurudeen A Adegoke, Yizhe Mao, Camelia Quek, Ellis Patrick

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First-line chemoimmunotherapy and immunotherapy in patients with non-small cell lung cancer and brain metastases: a registry study by Lauren Julia Brown, Lauren Julia Brown, Lauren Julia Brown, Lauren Julia Brown, Victor Khou, Victor Khou, Victor Khou, Chris Brown, Marliese Alexander, Marliese Alexander, Dasantha Jayamanne, Dasantha Jayamanne, Dasantha Jayamanne, Joe Wei, Lauren Gray, Wei Yen Chan, Wei Yen Chan, Samuel Smith, Susan Harden, Susan Harden, Antony Mersiades, Antony Mersiades, Lydia Warburton, Lydia Warburton, Malinda Itchins, Malinda Itchins, Malinda Itchins, Jenny H. Lee, Jenny H. Lee, Nick Pavlakis, Nick Pavlakis, Nick Pavlakis, Stephen J. Clarke, Stephen J. Clarke, Stephen J. Clarke, Michael Boyer, Michael Boyer, Adnan Nagrial, Adnan Nagrial, Adnan Nagrial, Eric Hau, Eric Hau, Eric Hau, Eric Hau, Ines Pires da Silva, Ines Pires da Silva, Ines Pires da Silva, Steven Kao, Steven Kao, Benjamin Y. Kong, Benjamin Y. Kong, Benjamin Y. Kong, Benjamin Y. Kong

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Efficacy and safety of anti-PD1 monotherapy or in combination with ipilimumab after BRAF/MEK inhibitors in patients with BRAF mutant metastatic melanoma by Lisa Zimmer, Serigne Lo, Celeste Lebbe, Olivier Michielin, Ines Pires da Silva, Paolo Antonio Ascierto, Matteo Carlino, Alexander Menzies, Douglas B Johnson, Claudia Trojanello, Georgina Long, Tasnia Ahmed, Clara Allayous, Johanna Mangana, Florentia Dimitriou, Danny Zakria, Camille Gerard

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Stroma-infiltrating T cell spatiotypes define immunotherapy outcomes in adolescent and young adult patients with melanoma by Xinyu Bai, Grace H. Attrill, Tuba N. Gide, Peter M. Ferguson, Kazi J. Nahar, Ping Shang, Ismael A. Vergara, Umaimainthan Palendira, Ines Pires da Silva, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott, Camelia Quek

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Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy by Andrew J Colebatch, John F Thompson, Serigne Lo, Ines Pires da Silva, Georgina V Long, Richard A Scolyer, Kazi J Nahar, Tasnia Ahmed, Umaimainthan Palendira, Alexander M Menzies, Jordan W Conway, Matteo S Carlino, Ismael A Vergara, James S Wilmott, Grace Heloise Attrill, Carina N Owen

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Distinct pretreatment innate immune landscape and posttreatment T cell responses underlie immunotherapy-induced colitis by Kazi J. Nahar, Felix Marsh-Wakefield, Robert V. Rawson, Tuba N. Gide, Angela L. Ferguson, Ruth Allen, Camelia Quek, Ines Pires da Silva, Stephen Tattersal, Christopher J. Kiely, Neomal Sandanayake, Matteo S. Carlino, Geoff McCaughan, James S. Wilmott, Richard A. Scolyer, Georgina V. Long, Alexander M. Menzies, Umaimainthan Palendira

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Cross-platform comparison of immune signatures in immunotherapy-treated patients with advanced melanoma using a rank-based scoring approach by Yizhe Mao, Tuba N. Gide, Nurudeen A. Adegoke, Camelia Quek, Nigel Maher, Alison Potter, Ellis Patrick, Robyn P. M. Saw, John F. Thompson, Andrew J. Spillane, Kerwin F. Shannon, Matteo S. Carlino, Serigne N. Lo, Alexander M. Menzies, Inês Pires da Silva, Georgina V. Long, Richard A. Scolyer, James S. Wilmott

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Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites by John F Thompson, Serigne Lo, Ines Pires da Silva, Georgina V Long, Richard A Scolyer, Andrew J Spillane, Robert V Rawson, Tasnia Ahmed, Jordan W Conway, Matteo S Carlino, Ismael A Vergara, James S Wilmott, Grace Heloise Attrill, Tuba N Gide, Robyn P M Saw, Kerwin F Shannon, Brindha Shivalingam, Alexander Maxwell Menzies

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Comprehensive analysis of cutaneous and uveal melanoma liver metastases by Annegien Broeks, Ines Pires da Silva, Sarah Warren, Pia Kvistborg, Georgina V Long, Richard A Scolyer, Christian U Blank, Esmee P Hoefsmit, Elisa A Rozeman, Trieu My Van, Petros Dimitriadis, Jordan W Conway, Jacqueline E van der Wal, Steven L C Ketelaars, Kaspar Bresser, Ron M Kerkhoven, Jason W Reeves, Ellen W Kapiteijn, Ton N M Schumacher

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A Response Letter to Kosaka et al. Regarding Manuscript Titled: “Radiotherapy Improves Survival in Non–Small Cell Lung Cancer Following Oligoprogression on Immunotherapy: A Cohort... by Lauren Julia Brown, M.B.B.S., MClinTRes, FRACP, Julie Ahn, M.B.B.S., Bo Gao, BmedSci, M.B.B.S., FRACP, PhD, Harriet Gee, M.B.B.S., DPhil, FRANZCR, Adnan Nagrial, M.B.B.S., FRACP, PhD, Inês Pires da Silva, MD, FRACP, PhD, Eric Hau, BSc (Med), M.B.B.S., Grad Cert (Biostat), FRANZCR, PHD

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Radiotherapy Improves Survival in NSCLC After Oligoprogression on Immunotherapy: A Cohort Study by Lauren Julia Brown, M.B.B.S., MClinTRes, FRACP, Julie Ahn, M.B.B.S., Bo Gao, BMedSci M.B.B.S., FRACP, PhD, Harriet Gee, M.B.B.S., DPhil, FRANZCR, Adnan Nagrial, M.B.B.S., FRACP, PhD, Inês Pires da Silva, MD, FRACP, PhD, Eric Hau, BSc (Med), M.B.B.S., Grad Cert (Biostat), FRANZCR, PhD

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