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Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia by Kristin Hartmann, Diego Sepulveda-Falla, Indigo V. L. Rose, Charlotte Madore, Christiane Muth, Jakob Matschke, Oleg Butovsky, Shane Liddelow, Markus Glatzel, Susanne Krasemann
Published 2019-05-01
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mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes by Kun Leng, Brendan Rooney, Frank McCarthy, Wenlong Xia, Indigo V. L. Rose, Sophie Bax, Marcus Chin, Saeed Fathi, Kari A. Herrington, Manuel Leonetti, Aimee Kao, Stephen P. J. Fancy, Joshua E. Elias, Martin Kampmann
Published 2024-08-01
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Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin by Hyosung Kim, Kun Leng, Jinhee Park, Alexander G. Sorets, Suil Kim, Alena Shostak, Rebecca J. Embalabala, Kate Mlouk, Ketaki A. Katdare, Indigo V. L. Rose, Sarah M. Sturgeon, Emma H. Neal, Yan Ao, Shinong Wang, Michael V. Sofroniew, Jonathan M. Brunger, Douglas G. McMahon, Matthew S. Schrag, Martin Kampmann, Ethan S. Lippmann
Published 2022-11-01
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