A mathematical methodology for determining the temporal order of pathway alterations arising during gliomagenesis. Autor Yu-Kang Cheng, Rameen Beroukhim, Ross L Levine, Ingo K Mellinghoff, Eric C Holland, Franziska Michor

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A kinase-independent function of AKT promotes cancer cell survival Autor Igor Vivanco, Zhi C Chen, Barbara Tanos, Barbara Oldrini, Wan-Ying Hsieh, Nicolas Yannuzzi, Carl Campos, Ingo K Mellinghoff

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Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death Autor Nicholas A Graham, Martik Tahmasian, Bitika Kohli, Evangelia Komisopoulou, Maggie Zhu, Igor Vivanco, Michael A Teitell, Hong Wu, Antoni Ribas, Roger S Lo, Ingo K Mellinghoff, Paul S Mischel, Thomas G Graeber

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Phase I clinical trial of temsirolimus and perifosine for recurrent glioblastoma Autor Thomas J. Kaley, Katherine S. Panageas, Elena I. Pentsova, Ingo K. Mellinghoff, Craig Nolan, Igor Gavrilovic, Lisa M. DeAngelis, Lauren E. Abrey, Eric C. Holland, Antonio Omuro, Mario E. Lacouture, Emmy Ludwig, Andrew B. Lassman

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Incidence of brain metastases in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy with trastuzumab and pertuzumab Autor Emanuela Ferraro, Jasmeet Singh, Sujata Patil, Pedram Razavi, Shanu Modi, Sarat Chandarlapaty, Andrea V. Barrio, Rachna Malani, Ingo K. Mellinghoff, Adrienne Boire, Hannah Y. Wen, Edi Brogi, Andrew D. Seidman, Larry Norton, Mark E. Robson, Chau T. Dang

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Inferring loss-of-heterozygosity from unpaired tumors using high-density oligonucleotide SNP arrays. Autor Rameen Beroukhim, Ming Lin, Yuhyun Park, Ke Hao, Xiaojun Zhao, Levi A Garraway, Edward A Fox, Ephraim P Hochberg, Ingo K Mellinghoff, Matthias D Hofer, Aurelien Descazeaud, Mark A Rubin, Matthew Meyerson, Wing Hung Wong, William R Sellers, Cheng Li

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Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study Autor Lauren R. Schaff, Mina Lobbous, Dean Carlow, Ryan Schofield, Igor T. Gavrilovic, Alexandra M. Miller, Jacqueline B. Stone, Anna F. Piotrowski, Ugur Sener, Anna Skakodub, Edward P. Acosta, Kevin J. Ryan, Ingo K. Mellinghoff, Lisa M. DeAngelis, Louis B. Nabors, Christian Grommes

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EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer Autor Barbara Oldrini, Wan-Ying Hsieh, Hediye Erdjument-Bromage, Paolo Codega, Maria Stella Carro, Alvaro Curiel-García, Carl Campos, Maryam Pourmaleki, Christian Grommes, Igor Vivanco, Daniel Rohle, Craig M. Bielski, Barry S. Taylor, Travis J. Hollmann, Marc Rosenblum, Paul Tempst, John Blenis, Massimo Squatrito, Ingo K. Mellinghoff

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Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. Autor Tim F Cloughesy, Koji Yoshimoto, Phioanh Nghiemphu, Kevin Brown, Julie Dang, Shaojun Zhu, Teli Hsueh, Yinan Chen, Wei Wang, David Youngkin, Linda Liau, Neil Martin, Don Becker, Marvin Bergsneider, Albert Lai, Richard Green, Tom Oglesby, Michael Koleto, Jeff Trent, Steve Horvath, Paul S Mischel, Ingo K Mellinghoff, Charles L Sawyers

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Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions Autor Douglas A. Mata, Jamal K. Benhamida, Andrew L. Lin, Chad M. Vanderbilt, Soo-Ryum Yang, Liliana B. Villafania, Donna C. Ferguson, Philip Jonsson, Alexandra M. Miller, Viviane Tabar, Cameron W. Brennan, Nelson S. Moss, Martin Sill, Ryma Benayed, Ingo K. Mellinghoff, Marc K. Rosenblum, Maria E. Arcila, Marc Ladanyi, Tejus A. Bale

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Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures Autor Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber

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Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers Autor Walid K. Chatila, Henry Walch, Jaclyn F. Hechtman, Sydney M. Moyer, Valeria Sgambati, David M. Faleck, Amitabh Srivastava, Laura Tang, Jamal Benhamida, Dorina Ismailgeci, Carl Campos, Fan Wu, Qing Chang, Efsevia Vakiani, Elisa de Stanchina, Martin R. Weiser, Maria Widmar, Rhonda K. Yantiss, Manish A. Shah, Adam J. Bass, Zsofia K. Stadler, Lior H. Katz, Ingo K. Mellinghoff, Nilay S. Sethi, Nikolaus Schultz, Karuna Ganesh, David Kelsen, Rona Yaeger

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Real-world experience with circulating tumor DNA in cerebrospinal fluid from patients with central nervous system tumors Autor Richard A. Hickman, Alexandra M. Miller, Bridget M. Holle, Justin Jee, Si-Yang Liu, Dara Ross, Helena Yu, Gregory J. Riely, Christina Ombres, Alexandra N. Gewirtz, Anne S. Reiner, Subhiksha Nandakumar, Adam Price, Thomas J. Kaley, Maya S. Graham, Chad Vanderbilt, Satshil Rana, Katherine Hill, Kiana Chabot, Carl Campos, Khedoudja Nafa, Neerav Shukla, Matthias Karajannis, Bob Li, Michael Berger, Marc Ladanyi, Elena Pentsova, Adrienne Boire, A. Rose Brannon, Tejus Bale, Ingo K. Mellinghoff, Maria E. Arcila

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ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State Autor Yakov Chudnovsky, Dohoon Kim, Siyuan Zheng, Warren A. Whyte, Mukesh Bansal, Mark-Anthony Bray, Shuba Gopal, Matthew A. Theisen, Steve Bilodeau, Prathapan Thiru, Julien Muffat, Omer H. Yilmaz, Maya Mitalipova, Kevin Woolard, Jeongwu Lee, Riko Nishimura, Nobuo Sakata, Howard A. Fine, Anne E. Carpenter, Serena J. Silver, Roel G.W. Verhaak, Andrea Califano, Richard A. Young, Keith L. Ligon, Ingo K. Mellinghoff, David E. Root, David M. Sabatini, William C. Hahn, Milan G. Chheda

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Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. Autor Jeffrey C Lee, Igor Vivanco, Rameen Beroukhim, Julie H Y Huang, Whei L Feng, Ralph M DeBiasi, Koji Yoshimoto, Jennifer C King, Phioanh Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K Thomas, J Guillermo Paez, Timothy C Peck, David J Linhart, Karen A Glatt, Gad Getz, Robert Onofrio, Liuda Ziaugra, Ross L Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M Liau, Stanley F Nelson, P Nagesh Rao, Paul Mischel, Russell O Pieper, Tim Cloughesy, Daniel J Leahy, William R Sellers, Charles L Sawyers, Matthew Meyerson, Ingo K Mellinghoff

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