Editorial: Transcriptional control in normal and malignant B-lymphocytes by Jerome Moreaux, Jerome Moreaux, Alexander A. Shtil

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Var∣Decrypt: a novel and user-friendly tool to explore and prioritize variants in whole-exome sequencing data by Mohammad Salma, Elina Alaterre, Jérôme Moreaux, Eric Soler

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Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma by Angélique Bruyer, Laure Dutrieux, Hugues de Boussac, Thibaut Martin, Djamila Chemlal, Djamila Chemlal, Nicolas Robert, Guilhem Requirand, Guillaume Cartron, Guillaume Cartron, Laure Vincent, Charles Herbaux, Charles Herbaux, Charles Herbaux, Malik Lutzmann, Caroline Bret, Caroline Bret, Caroline Bret, Philippe Pasero, Jérôme Moreaux, Jérôme Moreaux, Jérôme Moreaux, Jérôme Moreaux, Sara Ovejero, Sara Ovejero

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Single-hit genome editing optimized for maturation in B cells redirects their specificity toward tumor antigens by Natsuko Ueda, Marine Cahen, Jenny Leonard, Laurent Deleurme, Stéphane Dreano, Christophe Sirac, Anne Galy, Jérôme Moreaux, Yannic Danger, Michel Cogné

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MRE11 and TREX1 control senescence by coordinating replication stress and interferon signaling by Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé, Nail Bouzalmad, Baptiste Leray, Audrey Vernet, Clément Mettling, Jérôme Moreaux, Philippe Pasero, Yea-Lih Lin

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TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines by Jérôme Moreaux, Dirk Hose, Michel Jourdan, Thierry Reme, Michael Hundemer, Marion Moos, Nicolas Robert, Philippe Moine, John De Vos, Hartmut Goldschmidt, Bernard Klein

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S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability in multiple myeloma by Yanmeng Wang, Catharina Muylaert, Arne Wyns, Philip Vlummens, Kim De Veirman, Karin Vanderkerken, Esther Zaal, Celia Berkers, Jérome Moreaux, Elke De Bruyne, Eline Menu

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PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression by Marion Haas, Sabrina Cherfa, Léa Nguyen, Maxence Bourgoin, Gersende Caron, Elise Dessauge, Tony Marchand, Laurent Delpy, Patrick Auberger, Jérôme Moreaux, Arnaud Jacquel, Thierry Fest

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FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population by Michaël Constantinides, Nicolas Robert, Caroline Multrier, Loïs Coënon, Mauricio Campos-Mora, Carine Jacquard, Fei Gao, Sara Zemiti, Jessy Presumey, Guillaume Cartron, Jérome Moreaux, Martin Villalba

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A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines by Jérôme Moreaux, Bernard Klein, Régis Bataille, Géraldine Descamps, Sophie Maïga, Dirk Hose, Hartmut Goldschmidt, Anna Jauch, Thierry Rème, Michel Jourdan, Martine Amiot, Catherine Pellat-Deceunynck

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Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma by Alboukadel Kassambara, Dirk Hose, Jérôme Moreaux, Brian A. Walker, Alexei Protopopov, Thierry Reme, Franck Pellestor, Véronique Pantesco, Anna Jauch, Gareth Morgan, Hartmut Goldschmidt, Bernard Klein

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Kinome expression profiling to target new therapeutic avenues in multiple myeloma by Hugues de Boussac, Angélique Bruyer, Michel Jourdan, Anke Maes, Nicolas Robert, Claire Gourzones, Laure Vincent, Anja Seckinger, Guillaume Cartron, Dirk Hose, Elke De Bruyne, Alboukadel Kassambara, Philippe Pasero, Jérôme Moreaux

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The hydroxymethylome of multiple myeloma identifies FAM72D as a 1q21 marker linked to proliferation by Fabrice Chatonnet, Amandine Pignarre, Aurélien A. Sérandour, Gersende Caron, Stéphane Avner, Nicolas Robert, Alboukadel Kassambara, Audrey Laurent, Maud Bizot, Xabier Agirre, Felipe Prosper, José I. Martin-Subero, Jérôme Moreaux, Thierry Fest, Gilles Salbert

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The NADPH oxidase NOX2 is a marker of adverse prognosis involved in chemoresistance of acute myeloid leukemias by Rosa Paolillo, Mathias Boulanger, Pierre Gâtel, Ludovic Gabellier, Marion De Toledo, Denis Tempé, Rawan Hallal, Dana Akl, Jérôme Moreaux, Hayeon Baik, Elise Gueret, Christian Recher, Jean-Emmanuel Sarry, Guillaume Cartron, Marc Piechaczyk, Guillaume Bossis

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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth by Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero

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Proliferation is a central independent prognostic factor and target for personalized and risk-adapted treatment in multiple myeloma by Dirk Hose, Thierry Rème, Thomas Hielscher, Jérôme Moreaux, Tobias Messner, Anja Seckinger, Axel Benner, John D. Shaughnessy, Bart Barlogie, Yiming Zhou, Jens Hillengass, Uta Bertsch, Kai Neben, Thomas Möhler, Jean François Rossi, Anna Jauch, Bernard Klein, Hartmut Goldschmidt

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RNA-sequencing based first choice of treatment and determination of risk in multiple myeloma by Martina Emde-Rajaratnam, Susanne Beck, Susanne Beck, Vladimir Benes, Hans Salwender, Uta Bertsch, Christoph Scheid, Mathias Hänel, Katja Weisel, Thomas Hielscher, Marc S. Raab, Hartmut Goldschmidt, Hartmut Goldschmidt, Anna Jauch, Ken Maes, Elke De Bruyne, Eline Menu, Kim De Veirman, Jérôme Moreaux, Karin Vanderkerken, Anja Seckinger, Dirk Hose

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The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells by Niels Weinhold, Tobias Meissner, David C Johnson, Anja Seckinger, Jérôme Moreaux, Asta Försti, Bowang Chen, Jolanta Nickel, Daniel Chubb, Andrew C. Rawstron, Chi Doughty, Nasrin B. Dahir, Dil B. Begum, Kwee Young, Brian A. Walker, Per Hoffmann, Marcus M. Nöthen, Faith E. Davies, Bernard Klein, Hartmut Goldschmidt, Gareth J. Morgan, Richard S Houlston, Dirk Hose, Kari Hemminki

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