P1037: DOES EARLY INTERVENTION IN MYELOFIBROSIS IMPACT OUTCOMES? A POOLED ANALYSIS OF THE COMFORT I AND II STUDIES by C. Harrison, J.-J. Kiladjian, A. M. Vannucchi, R. A. Mesa, R. M. Scherber, J. Hamer-Maansson, S. Verstovsek

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S193: GENOMIC AND FUNCTIONAL IMPACT OF TP53 INACTIVATION IN JAK2V617F MYELOPROLIFERATIVE NEOPLASMS: A TRANSGENIC MOUSE MODEL APPROACH. by P. GOU, D. LIU, E. Lauret, N. Maslah, V. Montcuquet, V. meignin, J.-J. Kiladjian, B. Cassinat, S. Giraudier

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P980: JAK2V617F-DEPENDENT DOWN REGULATION OF SHP1 EXPRESSION PARTICIPATES IN THE SELECTION OF MPN CELLS IN THE PRESENCE OF TGFΒ by C. Aoun, N. Salomao, N. Maslah, S. Awan Toor, G. Letort, P. Gou, J.-J. Kiladjian, S. Giraudier, B. Cassinat

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P1029: MATCHING-ADJUSTED INDIRECT COMPARISON (MAIC) OF PELABRESIB (CPI-0610) IN COMBINATION WITH RUXOLITINIB VS RUXOLITINIB OR FEDRATINIB MONOTHERAPY IN PATIENTS WITH INTERMEDIATE... by V. Gupta, J. Mascarenhas, M. Kremyanskaya, R. K. Rampal, M. Talpaz, J.-J. Kiladjian, A. Vannucchi, S. Verstovsek, G. Colak, D. Dey, C. Harrison

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P1069: RETROSPECTIVE COMPARISON OF PATIENT OUTCOMES ON PACRITINIB VERSUS RUXOLITINIB IN PATIENTS WITH MYELOFIBROSIS AND THROMBOCYTOPENIA by C. Harrison, P. Bose, R. Mesa, A. Gerds, S. Oh, J.-J. Kiladjian, V. García-Gutierrez, A. Vannucchi, C. Scheid, M. Sobas, S. Verstovsek, S. Buckley, K. Roman-Torres, J. Mascarenhas

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P1041: IMPACT OF FEDRATINIB ON SPLEEN VOLUME AND MYELOFIBROSIS SYMPTOMS IN PATIENTS WITH SUBSTANTIAL SPLENOMEGALY: POST HOC ANALYSES FROM THE JAKARTA AND JAKARTA2 TRIALS by J.-J. Kiladjian, A. Tefferi, F. Passamonti, A. Vannucchi, M. Talpaz, F. Cervantes, C. N. Harrison, R. A. Mesa, J. Mascarenhas, N. Schaap, S. Verstovsek, T. Devos, S. Rose, J. Zhang, O. Sy, A. Pardanani

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P1048: MYF3001: A RANDOMIZED OPEN LABEL, PHASE 3 STUDY TO EVALUATE IMETELSTAT VERSUS BEST AVAILABLE THERAPY IN PATIENTS WITH INTERMEDIATE-2 OR HIGH-RISK MYELOFIBROSIS REFRACTORY TO... by J. Mascarenhas, C. N. Harrison, J.-J. Kiladjian, R. S. Komrokji, S. Koschmieder, A. M. Vannucchi, T. Berry, D. Redding, L. Sherman, S. Dougherty, L. Peng, L. Sun, F. Huang, Y. Wan, F. M. Feller, A. Rizo, S. Verstovsek

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S196: ROPEGINTERFERON ALFA-2B ACHIEVES PATIENT-SPECIFIC TREATMENT GOALS IN POLYCYTHEMIA VERA: FINAL RESULTS FROM THE PROUD-PV/CONTINUATION-PV STUDIES by H. Gisslinger, C. Klade, P. Georgiev, D. Krochmalczyk, L. Gercheva-Kyuchukova, M. Egyed, P. Dulicek, A. Illes, H. Pylypenko, L. Sivcheva, J. Mayer, V. Yablokova, V. Empson, K. Krejcy, H. Hasselbalch, R. Kralovics, J.-J. Kiladjian

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P1042: SAFETY AND TOLERABILITY RESULTS FROM THE PHASE 3B FREEDOM TRIAL OF FEDRATINIB (FEDR), AN ORAL, SELECTIVE JAK2 INHIBITOR, IN PATIENTS WITH MYELOFIBROSIS (MF) PREVIOUSLY TREAT... by V. Gupta, A. Yacoub, S. Verstovsek, R. A. Mesa, C. N. Harrison, G. Barosi, J.-J. Kiladjian, H. J. Deeg, S. Fazal, L. Foltz, R. J. Mattison, C. B. Miller, V. Parameswaran, C. Hernandez, J. Zhang, M. Talpaz

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RESULTS OF THE PEGASUS PHASE 3 RANDOMIZED TRIAL DEMONSTRATING SUPERIORITY OF THE C3 INHIBITOR PEGCETACOPLAN COMPARED TO ECULIZUMAB IN PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINU... by H. Weitz, P. Hillmen, J. Szer, A. Röth, B. Höchsmann, J. Panse, K. Usuki, M. Griffin, J. Kiladjian, C. Decastro, H. Nishimori, L. Tan, M. Hamdani, P. Deschatelets, C. Francois, F. Grossi, A. Risitano, R.P. Latour

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P1050: THROMBOCYTOPENIC MYELOFIBROSIS (MF) PATIENTS PREVIOUSLY TREATED WITH A JAK INHIBITOR IN A PHASE 3 RANDOMIZED STUDY OF MOMELOTINIB (MMB) VERSUS DANAZOL (DAN) [MOMENTUM] by A. Vannucchi, R. Mesa, A. Gerds, H. K. Al-Ali, D. Lavie, A. Kuykendall, S. Grosicki, A. Iurlo, Y. T. Goh, M. Lazaroiu, M. Egyed, M. L. Fox, D. McLornan, A. Perkins, S.-S. Yoon, V. Gupta, J.-J. Kiladjian, R. Donahue, J. Kawashima, S. Verstovsek

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S195: MOMENTUM: PHASE 3 RANDOMIZED STUDY OF MOMELOTINIB (MMB) VERSUS DANAZOL (DAN) IN SYMPTOMATIC AND ANEMIC MYELOFIBROSIS (MF) PATIENTS PREVIOUSLY TREATED WITH A JAK INHIBITOR by S. Verstovsek, A. Vannucchi, A. Gerds, H. K. Al-Ali, D. Lavie, A. Kuykendall, S. Grosicki, A. Iurlo, Y. T. Goh, M. Lazaroiu, M. Egyed, M. L. Fox, D. McLornan, A. Perkins, S.-S. Yoon, V. Gupta, J.-J. Kiladjian, R. Donahue, J. Kawashima, R. Mesa

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S198: BET INHIBITOR PELABRESIB (CPI-0610) COMBINED WITH RUXOLITINIB IN PATIENTS WITH MYELOFIBROSIS — JAK INHIBITOR-NAÏVE OR WITH SUBOPTIMAL RESPONSE TO RUXOLITINIB — PRELIMINARY DA... by J. Mascarenhas, M. Kremyanskaya, A. Patriarca, C. Harrison, P. Bose, R. K. Rampal, F Palandri, T. Devos, F. Passamonti, G. Hobbs, M. Talpaz, A. Vannucchi, J.-J. Kiladjian, S. Verstovsek, R. Hoffman, M. E. Salama, D. Chen, P. Taverna, A. Chang, G. Colak, S. Klein, V. Gupta

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P1030: MANIFEST-2, A GLOBAL, PHASE 3, RANDOMIZED, DOUBLE-BLIND, ACTIVE-CONTROL STUDY OF PELABRESIB (CPI-0610) AND RUXOLITINIB VS PLACEBO AND RUXOLITINIB IN JAK INHIBITOR-NAÏVE MYEL... by C. Harrison, R. K. Rampal, V. Gupta, S. Verstovsek, M. Talpaz, J.-J. Kiladjian, R. Mesa, A. Kuykendall, A. Vannucchi, F. Palandri, S. Grosicki, T. Devos, E. Jourdan, M. J. Wondergem, H. K. Al-Ali, V. Buxhofer-Ausch, A. Alvarez-Larrán, S. Akhani, R. Muñoz-Carerras, Y. Sheykin, G. Colak, M. Harris, J. Mascarenhas

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P995: MYELOID NEOPLASMS-ASSOCIATED GENE VARIANTS IN 639 PATIENTS WITH POST-POLYCYTHEMIA VERA AND POST-ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS: AN ANALYSIS OF THE MYSEC COHORT by B. Mora, P. Guglielmelli, A. Kuykendall, M. Maffioli, G. Rotunno, R. S. Komrokji, F. Palandri, J.-J. Kiladjian, A. Iurlo, G. Auteri, D. Cattaneo, V. De Stefano, S. Salmoiraghi, T. Devos, F. Cervantes, M. Merli, A. Campagna, G. Benevolo, M. Brociner, F. Albano, J. Gotlib, M. Caramella, M. Ruggeri, D. M. Ross, F. Orsini, C. Pessina, I. Colugnat, F. Pallotti, T. Barbui, L. Bertù, M. G. Della Porta, A. M. Vannucchi, F. Passamonti

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P1009: PREDICTORS OF HOSPITALIZATION AND SEVERE OUTCOMES IN PATIENTS WITH MPN AND COVID-19 by T. Barbui, A. Carobbio, A. Masciulli, A. Iurlo, M. A. Sobas, E. M. Elli, E. Rumi, V. De Stefano, F. Lunghi, M. Marchetti, R. Daffini, M. Gasior Kabat, B. Cuevas, M. L. Fox, M. M. Andrade Campos, F. Palandri, P. Guglielmelli, G. Benevolo, C. Harrison, M. A. Foncillas, M. Bonifacio, A. Alvarez-Larran, J.-J. Kiladjian, E. Bolanos Calderon, A. Patriarca, K. S. Quiroz Cervantes, M. Griesshammer, V. Garcia-Gutierrez, A. Marin Sanchez, E. Magro Mazo, M. Ruggeri, J. C. Hernandez-Boluda, S. Osorio, G. Carreno-Tarragona, M. Sagues Serrano, R. Kusec, B. Navas Elorza, A. Angona, B. Xicoy Cirici, E. Lopez Abadia, S. Koschmieder, E. Cichocka, A. Kulikowska de Nałęcz, M. Bellini, D. Cattaneo, C. Bucelli, F. Cavalca, O. Borsani, S. Betti, N. Curto-Garcia, S. Carbonell, L. Benajiba, A. Rambaldi, A. M. Vannucchi

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