S138: MICROENVIRONMENT-REGULATED TRANSCRIPTIONS FACTORS AHR AND HIF-1Α EXPRESSION IN TREGS PROMOTE CLL PROGRESSION BY IMPAIRING CD8+ T-CELL MEDIATED ANTI-TUMOR IMMUNITY by G. Pagano, M. Wierz, I. Fernandez Botana, S. Gonder, E. Gargiulo, E. Moussay, J. Paggetti

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P635: TARGETING THE ONE-CARBON METABOLISM AS NOVEL THERAPEUTIC STRATEGY IN CHRONIC LYMPHOCYTIC LEUKEMIA by E. Viry, A. Largeot, S. Gonder, S. Chemlal, N. Kiweler, J. Meiser, T. Helleday, E. Moussay, J. Paggetti

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P598: EBI3/IL-27 DEPLETED MICROENVIRONMENT FAVOURS TUMOUR PROGRESSION IN CHRONIC LYMPHOCYTIC LEUKAEMIA by I. C. Botana, G. Pagano, W. Marina, P. M. Roessner, B. Qu, A. Ramsay, B. Stamatopoulos, M. Seiffert, J. Paggetti, E. Moussay

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P619: TARGETING TRANSLATION BY DISRUPTING THE NEWLY IDENTIFIED PROHIBITIN-EIF4F COMPLEX AS A NOVEL THERAPEUTIC STRATEGY IN CHRONIC LYMPHOCYTIC LEUKEMIA by A. Largeot, V. Klapp, S. Gonder, E. Viry, M. Szpakowska, D. Perez Hernandez, G. Dittmar, A. Chevigné, L. Ysebaert, B. Stamatopoulos, L. Desaubry, J. Paggetti, E. Moussay

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S142: DECIPHERING THE COMPLEXITY OF T CELLS IN BLOOD AND LYMPH NODES OF PATIENTS WITH CLL BY INTEGRATIVE SINGLE-CELL RNA-SEQ AND MASS CYTOMETRY ANALYSES by L. Llaó Cid, J. Wong, M. Wierz, Y. Paul, S. Gonder, I. Fernandez Botana, T. Roider, S. Dietrich, D. Colomer, P. Lichter, M. Zapatka, E. Moussay, J. Paggetti, M. Seiffert

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S137: SMALL EXTRACELLULAR VESICLES IN THE LEUKEMIA MICROENVIRONMENT SUSTAIN CLL PROGRESSION BY HAMPERING T CELL-MEDIATED ANTI-TUMOR IMMUNITY by E. Gargiulo, E. Viry, P. E. Morande, A. Largeot, S. Gonder, F. Xian, N. Ioannou, M. Benzarti, F. Kleine Borgmann, M. Mittelbronn, G. Dittmar, P. V. Nazarov, J. Meiser, B. Stamatopoulos, A. G. Ramsay, E. Moussay, J. Paggetti

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