747 Phase 1 trial of LYL845, an autologous tumor-infiltrating lymphocyte (TIL) therapy enhanced with epigenetic reprogramming, for the treatment of advanced solid tumors by Joal D Beane, Yazan Samhouri, Brent A Hanks, John Hyngstrom, Sarah Weiss, Heidi Gillenwater, Yeonhee Kim, J Randolph Hecht, Bishwa J Ganguly, Hajime Hiraragi, Lucy Gong, Navid Nikoo

Detecting HLA loss of heterozygosity within a standard diagnostic sequencing workflow for prognostic and therapeutic opportunities by Ariane Lozac’hmeur, Tyler Danek, Qidi Yang, Mario G. Rosasco, John S. Welch, William Y. Go, Eric W. Ng, Armen Mardiros, David G. Maloney, Edward B. Garon, Kedar Kirtane, Diane M. Simeone, Julian R. Molina, Ameen A. Salahudeen, Michelle M. Stein, J. Randolph Hecht

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CITRINO: phase 1 dose escalation study of anti-LAG-3 antibody encelimab alone or in combination with anti-PD-1 dostarlimab in patients with advanced/metastatic solid tumours by J. Randolph Hecht, Jean-Marie Michot, David Bajor, Amita Patnaik, Ki Y. Chung, Judy Wang, Gerald Falchook, James M. Cleary, Richard Kim, Anuradha Krishnamurthy, Omkar Marathe, Hagop Youssoufian, Catherine Ellis, Angela Waszak, Srimoyee Ghosh, Hailei Zhang, Kaitlin Yablonski, Shruti D. Shah, Ivan Diaz-Padilla, Susanna Ulahannan

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636 BASECAMP-1: A master prescreening study to identify patients with high-risk or metastatic solid tumors with HLA loss of heterozygosity (LOH) in preparation for Tmod CAR T-cell... by Marcela Maus, Caron Jacobson, Frederick L Locke, Oliver Dorigo, David Maloney, Jennifer Specht, Saurabh Dahiya, Edward Garon, Diane M Simeone, John Welch, Kedar Kirtane, Marwan Fakih, Julian Molina, Ariane Lozac’hmeur, J Randolph Hecht, Jong Chul Park, Caleb Smith, Theodore Welling, M Pia Morelli, Patrick M Grierson, Tomislav Dragovich, William Y Go, Eric W Ng, Peter Vu, Jessica Tebbets, Gayanie Ong

634 EVEREST-1: A seamless phase 1/2 study of CEA logic-gated Tmod CAR T-cell therapy (A2B530) in patients with solid tumors associated with CEA expression also exhibiting HLA loss... by Sarah Nikiforow, Yi Lin, Marcela Maus, Armen Mardiros, Frederick L Locke, Scott Kopetz, Matthew Frigault, David Maloney, Jeffrey Ward, Jennifer Specht, Edward Garon, Diane M Simeone, John Welch, Kedar Kirtane, Marwan Fakih, Julian Molina, Kirstin Liechty, Ariane Lozac’hmeur, J Randolph Hecht, Caleb Smith, Salman R Punekar, Theodore Welling, M Pia Morelli, Patrick M Grierson, Sandip P Patel, Wen-Kai Weng, Tomislav Dragovich, Judy Vong, William Y Go, Eric W Ng

Impact of geography on prognostic outcomes of 21,509 patients with metastatic colorectal cancer enrolled in clinical trials: an ARCAD database analysis by Jun Yin, Shaheenah Dawood, Romain Cohen, Jeff Meyers, John Zalcberg, Takayuki Yoshino, Matthew Seymour, Tim Maughan, Leonard Saltz, Eric Van Cutsem, Alan Venook, Hans-Joachim Schmoll, Richard Goldberg, Paulo Hoff, J. Randolph Hecht, Herbert Hurwitz, Cornelis Punt, Eduard Diaz Rubio, Miriam Koopman, Chiara Cremolini, Volker Heinemann, Christophe Tournigard, Carsten Bokemeyer, Charles Fuchs, Niall Tebbutt, John Souglakos, Jean-Yves Doulliard, Fairooz Kabbinavar, Benoist Chibaudel, Aimery de Gramont, Qian Shi, Axel Grothey, Richard Adams

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