Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review by Rita Banzi, Jacques Demotes, Paula Garcia, Enrico Glaab, Armin Rauschenberger, Chiara Gerardi

Get full text

Disclosure of investigators' recruitment performance in multicenter clinical trials: a further step for research transparency. by Rafael Dal-Ré, David Moher, Christian Gluud, Shaun Treweek, Jacques Demotes-Mainard, Xavier Carné

Get full text

Funding multinational investigator-initiated clinical studies in Europe: why and how? by Marta del Álamo, Sabrina Lémeret, Cristina Nieto, Lara Pandya, Hans Hagen, Saul Walker, Jacques Demotes

Get full text

Depressive mixed state: Evidence for a new form of depressive state in type I and II bipolar patients by Katia M’Bailara, Donatienne Van den Bulke, Nicolas Demazeau, Jacques Demotes-Mainard, Chantal Henry

Get full text

Coordination of COVID-19 platform trials in Europe by Jacques Demotes, Victoria Charlotte Simensen, Keiko Ueda, Sareema Javaid, Paula Garcia, Burç Aydin, John-Arne Røttingen

Get full text

PedCRIN tool for the biosamples management in pediatric clinical trials by Viviana Giannuzzi, Lucia Ruggieri, Rosa Conte, Cristina Manfredi, Mariagrazia Felisi, Christine Kubiak, Mihaela Matei, Salma Malik, Jacques Demotes, Adriana Ceci, Donato Bonifazi

Get full text

The PERMIT guidelines for designing and implementing all stages of personalised medicine research by Paula Garcia, Rita Banzi, Vibeke Fosse, Chiara Gerardi, Enrico Glaab, Josep Maria Haro, Emanuela Oldoni, Raphaël Porcher, Judit Subirana-Mirete, Cecilia Superchi, Jacques Demotes

Get full text

Paediatric clinical research in Europe: an insight on experts’ needs and perspectives by Lucia Ruggieri, Adriana Ceci, Franco Bartoloni, Valèry Elie, Mariagrazia Felisi, Evelyne Jacqz-Aigrain, Mariangela Lupo, Salma Malik, Cristina Manfredi, Giorgio Reggiardo, Jacques Demotes, Donato Bonifazi

Get full text

Data Interoperability in COVID-19 Vaccine Trials: Methodological Approach in the VACCELERATE Project by Salma Malik, Zoi Pana Dorothea, Christos D Argyropoulos, Sophia Themistocleous, Alan J Macken, Olena Valdenmaiier, Frank Scheckenbach, Elena Bardach, Andrea Pfeiffer, Katherine Loens, Jordi Cano Ochando, Oliver A Cornely, Jacques Demotes-Mainard, Sergio Contrino, Gerd Felder

Get full text

A systematic literature review of evidence-based clinical practice for rare diseases: what are the perceived and real barriers for improving the evidence and how can they be overco... by Ana Rath, Valérie Salamon, Sandra Peixoto, Virginie Hivert, Martine Laville, Berenice Segrestin, Edmund A. M. Neugebauer, Michaela Eikermann, Vittorio Bertele, Silvio Garattini, Jørn Wetterslev, Rita Banzi, Janus C. Jakobsen, Snezana Djurisic, Christine Kubiak, Jacques Demotes-Mainard, Christian Gluud

Get full text

Centre for Statistical and Methodological Excellence (CESAME): A Consortium Initiative for Improving Methodology in Randomised Clinical Trials by Caroline Kamp Jørgensen, Markus Harboe Olsen, Niklas Nielsen, Theis Lange, Lawrence Mbuagbaw, Lehana Thabane, Laurent Billot, Nadine Binder, Silvio Garattini, Rita Banzi, Jacques Demotes, Elena Biagioli, Eliana Rulli, Guido Bertolini, Giovanni Nattino, Ole Mathiesen, Valter Torri, Christian Gluud, Janus Christian Jakobsen

Get full text

Specific barriers to the conduct of randomised clinical trials on medical devices by Edmund A. M. Neugebauer, Ana Rath, Sunya-Lee Antoine, Michaela Eikermann, Doerthe Seidel, Carsten Koenen, Esther Jacobs, Dawid Pieper, Martine Laville, Séverine Pitel, Cecilia Martinho, Snezana Djurisic, Jacques Demotes-Mainard, Christine Kubiak, Vittorio Bertele, Janus C. Jakobsen, Silvio Garattini, Christian Gluud

Get full text

Selecting Core Outcomes for Randomised Effectiveness trials In Type 2 diabetes (SCORE-IT): a patient and healthcare professional consensus on a core outcome set for type 2 diabetes by James Harris, Paula R Williamson, John P H Wilding, Nicola L Harman, Jennifer Logue, Leigh Perreault, Dave Curry, R John Pemberton, Gareth Thompson, Sean Tunis, Serena Battaglia, Florence Bietrix, Jacques Demotes-Mainard, Valerie Gailus-Durner, Silvio Garattini, Tim Moser, Cecilia A C Prinsen, Michael Raess, Adrian Sanz-Moreno, Caroline B Terwee

Get full text

Study designs for clinical trials applied to personalised medicine: a scoping review by Raphaël Porcher, Rita Banzi, Josep Maria Haro, Jacques Demotes, Florence Bietrix, Cecilia Superchi, Montserrat Carmona, Luis María Sánchez-Gómez, Paula Garcia, Frank Hulstaert, Alexander Grundmann, Iñaki Imaz-Iglesia, Enrico Glaab, Chiara Gerardi, Florie Brion Bouvier, Lorena San Miguel, Antonio L Andreu, Maria del Mar Polo-de Santos, Maddalena Fratelli, Vibeke Fosse, Rainer Girgenrath, Pascale Jonckheer, Setefilla Luengo Matos, Emmet McCormack, Anna Monistrol Mula, Albert Sanchez Niubo, Emanuela Oldoni, Teresa Torres

Get full text

Current state-of-the-art and gaps in platform trials: 10 things you should know, insights from EU-PEARL by Franz Koenig, Cécile Spiertz, Daniel Millar, Sarai Rodríguez-Navarro, Núria Machín, Ann Van Dessel, Joan Genescà, Juan M. Pericàs, Martin Posch, Adrian Sánchez-Montalva, Ana Belén Estevez, Àlex Sánchez, Anna Sanjuan, Elena Sena, Emma Granados, Esther Arévalo de Andrés, Fátima Nuñez, Gara Arteaga, Gabriela Perez Fuentes Ruiz, Guillermo Fernández, Jesus Rivera-Esteban, Joan Comella, Josep Antoni Ramos-Quiroga, Joan Genescà, Juan Espinosa, Juan Manuel Pericàs, Lada Murcia, Lucinda Cash-Gibson, Maria de Valles Silvosa, María Fernanda Barroso de Sousa, Olga Sánchez-Maroto Carrizo, Pol Ibañez-Jiménez, Salvador Augustin, Santiago Perez-Hoyos, Sarai Rodríguez-Navarro, Sergio Muñoz-Martínez, Silvia Serres, Susana Kalko, Amelie Michon, Anton Ussi, Ben Lydall, Edwin van de Ketterij, Ignacio Quiles, Tamara Carapina, Constantin Kumaus, Dariga Ramazanova, Elias Laurin Meyer, Franz Koenig, Marta Bofill Roig, Martin Brunner, Martin Posch, Pavla Krotka, Sonja Zehetmayer, Charlotte Carton, Eric Legius, Amina Begum, Carmine Pariante, Courtney Worrell, Giulia Lombardo, Luca Sforzini, Mollie Brown, Nancy Gullet, Nare Amasi-Hartoonian, Rosalie Ferner, Melisa Kose, Andrea Spitaleri, Arash Ghodousi, Clelia Di Serio, Daniela Cirillo, Federica Cugnata, Francesca Saluzzo, Francesco Benedetti, Maria Giovanna Scarale, Michela Zini, Paola Maria Rancoita, Riccardo Alagna, Sara Poletti, Britt Dhaenens, Johan Van Der Lei, Jurriaan de Steenwinkel, Maxim Moinat, Rianne Oostenbrink, Witte Hoogendijk, Michael Hölscher, Norbert Heinrich, Christian Otte, Cornelia Potratz, Dario Zocholl, Eugenia Kulakova, Frank Tacke, Jelena Brasanac, Jonas Leubner, Maja Krajewska, Michaela Maria Freitag, Stefan Gold, Thomas Zoller, Woo Ri Chae, Christel Daniel, Leila Kara, Morgan Vaterkowski, Nicolas Griffon, Pierre Wolkenstein, Raluca Pais, Vlad Ratziu, David Voets, Christophe Maes, Dipak Kalra, Geert Thienpoint, Jens Deckerck, Nathan Lea, Peter Singleton, Kert Viele, Peter Jacko, Scott Berry, Tom Parke, Amelie Michon, Burç Aydin, Christine Kubiak, Jacques Demotes, Keiko Ueda, Mihaela Matei, Sergio Contrino, Claas Röhl, Estefania Cordero, Fiona Greenhalgh, Hannes Jarke, Juliana Angelova, Mathieu Boudes, Stephan Dressler, Valentina Strammiello, Quentin Anstee, Iñaki Gutierrez-Ibarluzea, Maximilian Otte, Natalie Heimbach, Benjamin Hofner, Cora Burgwinkel, Hue Kaestel, Katharina Hees, Quynh Nguyen, Daniel Prieto-Alhambra, Eng Hooi (Cheryl) Tan, Mario Raviglione, Pierpaolo de Colombani, Simone Villa, Eduard Maron, Gareth Evans, Adam J. Savitz, Ann Van Dessel, Anna Duca, Anne Kaminski, Bie Wouters, Brandon Porter, Catherine Charron, Cecile Spiertz, Christopher Zizzamia, Daniel Millar, Danny Hasselbaink, David Orr, Divya Kesters, Ellen Hubin, Emma Davies, Eva-Maria Didden, Gabriela Guz, Evelyn Verstraete, Gary Mao, George Capuano, Heddie Martynowicz, Heidi De Smedt, Ingela Larsson, Ines Bruegelmans, Isabelle Coste, Jesus Maria Gonzalez Moreno, Julia Niewczas, Jiajun Xu, Karin Rombouts, Katherine Woo, Kathleen Wuyts, Kathryn Hersh, Khrista Oldenburg, Lingjiao Zhang, Mark Schmidt, Mark Szuch, Marija Todorovic, Maartje Mangelaars, Melissa Grewal, Molli Sandor, Nick Di Prospero, Pamela Van Houten, Pansy Minnick, Polyana Bastos, Robert Patrizi, Salvatore Morello, Severijn De Wilde, Tao Sun, Timothy Kline, Tine de Marez, Tobias Mielke, Tom Reijns, Vanina Popova, Yanina Flossbach, Yevgen Tymofyeyev, Zeger De Groote, Alex Sverdlov, Alexandra Bobirca, Annekatrin Krause, Catalin Bobrica, Daniela Heintz, Dominic Magirr, Ekkehard Glimm, Fabienne Baffert, Federica Castiglione, Franca Caruso, Francesco Patalano, Frank Bretz, Guenter Heimann, Ian Carbarns, Ignacio Rodríguez, Ioana Ratescu, Lisa Hampson, Marcos Pedrosa, Mareile Hark, Peter Mesenbrink, Sabina Hernandez Penna, Sarah Bergues-Lang, Susanne Baltes-Engler, Tasneem Arsiwala, Valeria Jordan Mondragon, Hua Guo, Jose Leite Da Costa, Carl-Fredrik Burman, George Kirk, Anders Aaes-Jørgensen, Jorgen Dirach, Mette Skalshøi Kjær, Alexandra Martin, Diyan Hristov, Florent Rousseaux, Norbert Hittel, Robert Dornheim, Daniel Evans, Nick Sykes, Camille Couvert, Catherine Leuven, Loïc Notelet, Madhavi Gidh-Jain, Mathieu Jouannin, Nadir Ammour, Suzanne Pierre, Volker Haufe, Yingwen Dong, Catherine Dubanchet, Nathalie de Préville, Tania Baltauss, Zhu Jian, Sara Shnider, Tal Bar-El, Annette Bakker, Marco Nievo, Uche Iloeje, Almari Conradie, Ece Auffarrth, Leandra Lombard, Majda Benhayoun, Morounfolu Olugbosi, Stephanie S. Seidel, Berta Gumí, Claudia García Guzmán, Eva Molero, Gisela Pairó, Núria Machin, Raimon Cardelús, Saira Ramasastry, Saskia Pelzer, Andreas Kremer, Erno Lindfors, Chris Lynch

Get full text