70 Deciphering the relationship between lymphocytes and macrophages within the tumor micro-environment using a workflow combining RNA transcripts detection and multiplex IHC on Bri... by Jerome Galon, Jacques Fieschi, Aurelie Collignon, Alex Trinh, Marion Olive, Maïté Chamourin, Alboukadel Kassambara, Lucie Sudre, Anthony Lebret, Giovanni Bussoti

57 Assessment of the spatial distribution of B cells subpopulations in the tumor microenvironment and tertiary lymphoid structures by Brightplex®, a sequential chromogenic multiple... by Jerome Galon, Aurelie Collignon, Alex Trinh, Marion Olive, Clémence Jaume, Maïté Chamourin, Nour Sfeir, Dylan Anselmo, Raana Ramouz-Charpentier, Georgia Culey, Christophe Haond, Jacques Fieschi-Meric

Trial watch : the gut microbiota as a tool to boost the clinical efficacy of anticancer immunotherapy by Romain Daillère, Lisa Derosa, Mélodie Bonvalet, Nicola Segata, Bertrand Routy, Manuela Gariboldi, Eva Budinská, I. Jolanda M. De Vries, Alessio Gordon Naccarati, Valérie Zitvogel, Carlos Caldas, Lars Engstrand, Sibylle Loilbl, Jacques Fieschi, Lucie Heinzerling, Guido Kroemer, Laurence Zitvogel

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Dissecting tumor lymphocyte infiltration to predict benefit from immune-checkpoint inhibitors in metastatic colorectal cancer: lessons from the AtezoT RIBE study by Chiara Cremolini, Daniele Rossini, Sara Lonardi, Filippo Pietrantonio, Gianluca Masi, Roberto Moretto, Alessandra Boccaccino, Jerome Galon, Jacques Fieschi, Stefano Tamberi, Gabriella Fontanini, Lisa Salvatore, Clara Ugolini, Alboukadel Kassambara, Emiliano Tamburini, Veronica Conca, Aurélie Catteau, Carlotta Antoniotti, Mirella Giordano, Agnese Proietti, Anello Marcello Poma

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Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung can... by François Ghiringhelli, Frederic Bibeau, Laurent Greillier, Jean-David Fumet, Alis Ilie, Florence Monville, Caroline Laugé, Aurélie Catteau, Isabelle Boquet, Amine Majdi, Erwan Morgand, Youssef Oulkhouir, Nicolas Brandone, Julien Adam, Thomas Sbarrato, Alboukadel Kassambara, Jacques Fieschi, Stéphane Garcia, Anne Laure Lepage, Pascale Tomasini, Jérôme Galon

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460 Spatial distribution of infiltrating T lymphocytes with Immunoscore® CR T cells exhaustion test helps stratification of NSCLC patients treated with PD1/PDL1 inhibitors in the P... by Noémie Resseguier, Julien Mazières, Fabrice Barlesi, Maurice Pérol, Thomas Sbarrato, Fanny Arnoux, Stéphane Garcia, Jacques Fieschi-Meric, Vanina Leca, Alboukadel Kassambara, Lamia Ghezali, Pernelle Outters, Christelle Cotteaux-Lautard, Florence Monville, Maryannick Le Ray, Marie Roumieux, Richard Malkoun, Arnaud Boyer, Louisiane Lebas, Hervé Pegliasco, Patricia Barré, Clarisse Audigier-valette, Sarah Zahi, Luc Odier, Stéphane Hominal, Laurent Greillier

782-C Regulatory T-cell tumor infiltration is associated to better outcome in advanced NSCLC patients under ≥2nd line anti-PD1/L1 monotherapy in the PIONeeR project by Lilian Laborde, Julien Mazières, Fabrice Barlesi, Jacques Fieschi, Maurice Pérol, Vanina Leca, Alboukadel Kassambara, Florence Monville, Maryannick Le Ray, Marie Roumieux, Richard Malkoun, Arnaud Boyer, Louisiane Lebas, Hervé Pegliasco, Patricia Barré, Clarisse Audigier-valette, Sarah Zahi, Stéphane Hominal, Laurent Greillier, Marcellin Landri, Margot Vasseur, Chafik Hamdad, Margaux Mercadal, Laurent Vanhille, Sebastien Benzekry, Stephanie Martinez, Patrice Ray, Lionel Falchero, Antoine Serre, Nicolas Cloarec, Ahmed Frikha, Pierre Bory