Editorial: Multi-omics data integration: key to thoroughly understanding the immune system by Cristina Jiménez, María Hernández-Sánchez, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Paula Díez, Paula Díez

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The Cellular Immune Response to Rabies Vaccination: A Systematic Review by Lisanne A. Overduin, Jacques J.M. van Dongen, Leonardus G. Visser

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Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective by Indu Khatri, Indu Khatri, Frank J. T. Staal, Jacques J. M. van Dongen

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Plasma cells are not restricted to the CD27+ phenotype: characterization of CD27-CD43+ antibody-secreting cells by Kris Covens, Kris Covens, Bert Verbinnen, Bert Verbinnen, Britt G. de Jong, Britt G. de Jong, Leen Moens, Leen Moens, Greet Wuyts, Geert Verheyen, Kris Nys, Jonathan Cremer, Stijn Smulders, Rik Schrijvers, Andreas Weinhäusel, Séverine Vermeire, Patrick Verschueren, Ellen De Langhe, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Menno C. van Zelm, Menno C. van Zelm, Xavier Bossuyt, Xavier Bossuyt

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PID comes full circle: Applications of V(D)J recombination excision circles in research, diagnostics and newborn screening of primary immunodeficiency disorders by Menno C. Van Zelm, Mirjam eVan Der Burg, Anton W. Langerak, Jacques J.M. Van Dongen

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Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic l... by Nicole S.D. Larmonie, Willem A. Dik, Jules P.P. Meijerink, Irene Homminga, Jacques J.M. van Dongen, Anton W. Langerak

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Redefining Non-Inferiority in Anamnestic Antibody Responses Using the Mean Increase of Log-Transformed Antibody Titers after Revaccination: Secondary Analysis of a Randomized Contr... by Lisanne A. Overduin, Patrick H. P. Soentjens, Jelle J. Goeman, Magdalena A. Berkowska, Jacques J. M. van Dongen, Leo G. Visser

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Performance of spectral flow cytometry and mass cytometry for the study of innate myeloid cell populations by Kyra van der Pan, Indu Khatri, Anniek L. de Jager, Alesha Louis, Sara Kassem, Brigitta A.E. Naber, Inge F. de Laat, Marjolijn Hameetman, Suzanne E.T. Comans, Alberto Orfao, Jacques J.M. van Dongen, Jacques J.M. van Dongen, Paula Díez, Paula Díez, Cristina Teodosio, Cristina Teodosio

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The New EU Regulation on In Vitro Diagnostic Medical Devices: Implications and Preparatory Actions for Diagnostic Laboratories by Bart R. Lubbers, Anke Schilhabel, Christa M. Cobbaert, David Gonzalez, Isabel Dombrink, Monika Brüggemann, W. Marieke Bitter, Jacques J.M. van Dongen

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Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-κB pathway by Ruud W.J. Meijers, Alice F. Muggen, Leticia G. Leon, Maaike de Bie, Jacques J.M. van Dongen, Rudi W. Hendriks, Anton W. Langerak

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Antigen receptor sequencing of paired bone marrow samples shows homogeneous distribution of acute lymphoblastic leukemia subclones by Prisca M.J. Theunissen, David van Zessen, Andrew P. Stubbs, Malek Faham, Christian M. Zwaan, Jacques J.M. van Dongen, Vincent H.J. Van Der Velden

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Quantitative proteomics of small numbers of closely-related cells: Selection of the optimal method for a clinical setting by Kyra van der Pan, Sara Kassem, Indu Khatri, Indu Khatri, Arnoud H. de Ru, George M. C. Janssen, Rayman T. N. Tjokrodirijo, Fadi al Makindji, Eftychia Stavrakaki, Anniek L. de Jager, Brigitta A. E. Naber, Inge F. de Laat, Alesha Louis, Wouter B. L. van den Bossche, Lisette B. Vogelezang, Rutger K. Balvers, Martine L. M. Lamfers, Peter A. van Veelen, Alberto Orfao, Alberto Orfao, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Cristina Teodosio, Cristina Teodosio, Cristina Teodosio, Paula Díez, Paula Díez, Paula Díez

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Critical Implications of IVDR for Innovation in Diagnostics: Input From the BioMed Alliance Diagnostics Task Force by Isabel Dombrink, Bart R. Lubbers, Loredana Simulescu, Robin Doeswijk, Olga Tkachenko, Elisabeth Dequeker, Alan G. Fraser, Jacques J. M. van Dongen, Christa Cobbaert, Monika Brüggemann, Elizabeth Macintyre

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Experience With IVDR Implementation in Three Diagnostic Laboratories: Messages to EU Health Institutions, Diagnostic Healthcare Payers, and Authorities by Bart R. Lubbers, Isabel Dombrink, Tomas Kalina, Mattias Hofmans, Morten S. Bruun, Simon J. Stanworth, Marie C. Béné, Konstanze Döhner, Monika Brüggemann, Elizabeth Macintyre, Jacques J.M. van Dongen

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Longitudinal Dynamics of Human B-Cell Response at the Single-Cell Level in Response to Tdap Vaccination by Indu Khatri, Annieck M. Diks, Erik B. van den Akker, Liesbeth E. M. Oosten, Jaap Jan Zwaginga, Marcel J. T. Reinders, Jacques J. M. van Dongen, Magdalena A. Berkowska

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In-depth blood immune profiling of Good syndrome patients by Alba Torres-Valle, Alba Torres-Valle, Alba Torres-Valle, Larraitz Aragon, Susana L. Silva, Susana L. Silva, Cristina Serrano, Miguel Marcos, Miguel Marcos, Miguel Marcos, Josefa Melero, Carolien Bonroy, Carolien Bonroy, Pedro Pablo Arenas-Caro, David Monzon Casado, Pedro Mikel Requejo Olaizola, Jana Neirinck, Jana Neirinck, Mattias Hofmans, Mattias Hofmans, Sonia de Arriba, María Jara, María Jara, María Jara, Carlos Prieto, Ana E. Sousa, Álvaro Prada, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Jacques J. M. van Dongen, Martín Pérez-Andrés, Martín Pérez-Andrés, Martín Pérez-Andrés, Martín Pérez-Andrés, Alberto Orfao, Alberto Orfao, Alberto Orfao, Alberto Orfao

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Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge by Annieck M. Diks, Hans de Graaf, Cristina Teodosio, Rick J. Groenland, Bas de Mooij, Muktar Ibrahim, Alison R. Hill, Robert C. Read, Jacques J.M. van Dongen, Magdalena A. Berkowska, on behalf of the IMI-2 PERISCOPE Consortium

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Delineating Human B Cell Precursor Development With Genetically Identified PID Cases as a Model by Marjolein W. J. Wentink, Tomas Kalina, Martin Perez-Andres, Lucia del Pino Molina, Hanna IJspeert, François G. Kavelaars, Arjan C. Lankester, Quentin Lecrevisse, Jacques J. M. van Dongen, Alberto Orfao, Mirjam van der Burg, Mirjam van der Burg

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Characterization of the early cellular immune response induced by HPV vaccines by Hella Pasmans, Magdalena A. Berkowska, Annieck M. Diks, Bas de Mooij, Rick J. Groenland, Lia de Rond, M. Alina Nicolaie, Sjoerd H. van der Burg, Jacques J. M. van Dongen, Fiona R. M. van der Klis, Anne-Marie Buisman

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Patient specific real-time PCR in precision medicine – Validation of IG/TR based MRD assessment in lymphoid leukemia by Anke Schilhabel, Monika Szczepanowski, Ellen J. van Gastel-Mol, Janina Schillalies, Jill Ray, Doris Kim, Michaela Nováková, Isabel Dombrink, Vincent H. J. van der Velden, Sebastian Boettcher, Monika Brüggemann, Michael Kneba, Jacques J. M. van Dongen, Anton W. Langerak, Matthias Ritgen

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