Experimental Chagas disease-induced perturbations of the fecal microbiome and metabolome. by Laura-Isobel McCall, Anupriya Tripathi, Fernando Vargas, Rob Knight, Pieter C Dorrestein, Jair L Siqueira-Neto

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Genome-scale metabolic models highlight stage-specific differences in essential metabolic pathways in Trypanosoma cruzi. by Isabel S Shiratsubaki, Xin Fang, Rodolpho O O Souza, Bernhard O Palsson, Ariel M Silber, Jair L Siqueira-Neto

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Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas Disease. by Danya A Dean, Gautham Gautham, Jair L Siqueira-Neto, James H McKerrow, Pieter C Dorrestein, Laura-Isobel McCall

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High-Throughput Screening of the ReFRAME Library Identifies Potential Drug Repurposing Candidates for <i>Trypanosoma cruzi</i> by Jean A. Bernatchez, Emily Chen, Mitchell V. Hull, Case W. McNamara, James H. McKerrow, Jair L. Siqueira-Neto

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Mechanism of Action of Methotrexate Against Zika Virus by Sungjun Beck, Zhe Zhu, Michelli F. Oliveira, Davey M. Smith, Jeremy N. Rich, Jean A. Bernatchez, Jair L. Siqueira-Neto

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Palstimolide A: A Complex Polyhydroxy Macrolide with Antiparasitic Activity by Lena Keller, Jair L. Siqueira-Neto, Julia M. Souza, Korina Eribez, Gregory M. LaMonte, Jennifer E. Smith, William H. Gerwick

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Cysteine proteases in protozoan parasites. by Jair L Siqueira-Neto, Anjan Debnath, Laura-Isobel McCall, Jean A Bernatchez, Momar Ndao, Sharon L Reed, Philip J Rosenthal

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An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi. by Seunghyun Moon, Jair L Siqueira-Neto, Carolina Borsoi Moraes, Gyongseon Yang, Myungjoo Kang, Lucio H Freitas-Junior, Michael A E Hansen

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Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways. by Jacob M Wozniak, Tatiana Araújo Silva, Diane Thomas, Jair L Siqueira-Neto, James H McKerrow, David J Gonzalez, Claudia M Calvet

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Dysregulation of Glycerophosphocholines in the Cutaneous Lesion Caused by <i>Leishmania major</i> in Experimental Murine Models by Adwaita R. Parab, Diane Thomas, Sharon Lostracco-Johnson, Jair L. Siqueira-Neto, James H. McKerrow, Pieter C. Dorrestein, Laura-Isobel McCall

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An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. by Jair L Siqueira-Neto, Seunghyun Moon, Jiyeon Jang, Gyongseon Yang, Changbok Lee, Hong Kee Moon, Eric Chatelain, Auguste Genovesio, Jonathan Cechetto, Lucio H Freitas-Junior

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Automated nuclear analysis of Leishmania major telomeric clusters reveals changes in their organization during the parasite's life cycle. by Fernando de M Dossin, Alexandre Dufour, Elodie Dusch, Jair L Siqueira-Neto, Carolina B Moraes, Gyong Seon Yang, Maria Isabel Cano, Auguste Genovesio, Lucio H Freitas-Junior

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In vitro anti-Trypanosoma cruzi activity enhancement of curcumin by its monoketone tetramethoxy analog diveratralacetone by Julia M. Souza, Tatiana M. Vieira, Ana Carolina B.B. Candido, Daiane Y. Tezuka, G. Subba Rao, Sérgio de Albuquerque, Antônio E.M. Crotti, Jair L. Siqueira-Neto, Lizandra G. Magalhães

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Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells by Jean A. Bernatchez, Michael Coste, Sungjun Beck, Grace A. Wells, Lucas A. Luna, Alex E. Clark, Zhe Zhu, David Hecht, Jeremy N. Rich, Christal D. Sohl, Byron W. Purse, Jair L. Siqueira-Neto

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Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds. by Jair L Siqueira-Neto, Ok-Ryul Song, Hyunrim Oh, Jeong-Hun Sohn, Gyongseon Yang, Jiyoun Nam, Jiyeon Jang, Jonathan Cechetto, Chang Bok Lee, Seunghyun Moon, Auguste Genovesio, Eric Chatelain, Thierry Christophe, Lucio H Freitas-Junior

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Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. by Laura-Isobel McCall, Amale El Aroussi, Jun Yong Choi, Debora F Vieira, Geraldine De Muylder, Jonathan B Johnston, Steven Chen, Danielle Kellar, Jair L Siqueira-Neto, William R Roush, Larissa M Podust, James H McKerrow

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A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using <i>Leishmania donovani</i> by Obaid Hayat, Nazif Ullah, Muhammad Sirajuddin, Miriam A. Giardini, Jennifer V. Nguyen, Karol R. Francisco, Lawrence J. Liu, Yujie Uli Sun, Svetlana Maurya, Dominic McGrosso, David J. Gonzalez, Conor R. Caffrey, Anjan Debnath, Jair L. Siqueira-Neto

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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase by Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley

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