381 SUPLEXA, a multimodal autologous cellular therapy, shows immunomodulatory behavior in cancer patients consistent with improved anti-tumor immune function by Rohit Joshi, Sharron Gargosky, Ganessan Kichenadasse, James A Lederer, Jeffrey Goh, Frank Borriello, John F Pulford, Ekaterina Murzin, Daniel Younger

727 Topline safety and efficacy update of SUPLEXA-101, a first-in-human, single agent study of SUPLEXA therapeutic cells in 28 patients with metastatic solid tumours by Rohit Joshi, Sharron Gargosky, Victoria Atkinson, James A Lederer, Jeffrey Goh, Vineet Kwatra, Warren Joubert, Meena Okera, Sarwan Bishnoi, Frank Borriello, Ganessan Kitchenadasse, George Nisyrios

Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models by Francesca Barone, Paul P Tak, Sean Lawler, James A Lederer, Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, E Antonio Chiocca

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Mesenchymal Stromal Cells Facilitate Neutrophil-Trained Immunity by Reprogramming Hematopoietic Stem Cells by Julie Ng, Anna E. Marneth, Alec Griffith, Daniel Younger, Sailaja Ghanta, Alan Jiao, Gareth Willis, Junwen Han, Jewel Imani, Bailin Niu, Joshua W. Keegan, Brandon Hancock, Fei Guo, Yang Shi, Mark A. Perrella, James A. Lederer

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Intratracheal transplantation of trophoblast stem cells attenuates acute lung injury in mice by Junwen Han, Gu Li, Minmin Hou, Julie Ng, Min-Young Kwon, Kevin Xiong, Xiaoliang Liang, Elizabeth Taglauer, Yuanyuan Shi, S. Alex Mitsialis, Stella Kourembanas, Souheil El-Chemaly, James A. Lederer, Ivan O. Rosas, Mark A. Perrella, Xiaoli Liu

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Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma by Marilin S. Koch, Mykola Zdioruk, Michal O. Nowicki, Alec M. Griffith, Estuardo Aguilar-Cordova, Laura K. Aguilar, Brian W. Guzik, Francesca Barone, Paul Peter Tak, Katharina Schregel, Michael S. Hoetker, James A. Lederer, E. Antonio Chiocca, Ghazaleh Tabatabai, Sean E. Lawler

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Checkpoint blockade-induced CD8+ T cell differentiation in head and neck cancer responders by Zhe Zhang, Yi Zhang, Fan Zhang, Xiaojing Ma, Ravindra Uppaluri, Robert Haddad, Jonathan D Schoenfeld, Shengqing Gu, Joshua Keegan, James A Lederer, Xiaoqing Wang, Zexian Zeng, Jingxin Fu, Liye Zhou, Ann Marie Egloff, Fei Guo, Katie M Campbell, Peter Du, Paul Zolkind, Rachel Riley, Yasutaka Nakahori, Obi Griffith, Robert T Manguso, X Shirley Liu

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Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis by Amélie M. Julé, Kacie J. Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, Maria L. Taylor, Julie Ng, James A. Lederer, Siobhan M. Case, Margaret H. Chang, Ezra M. Cohen, Fatma Dedeoglu, Melissa M. Hazen, Jonathan S. Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, Mindy S. Lo, Esra Meidan, Jordan E. Roberts, Mary Beth F. Son, Robert P. Sundel, Pui Y. Lee, Talal Chatila, Peter A. Nigrovic, Lauren A. Henderson

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Type I interferon signature and cycling lymphocytes in macrophage activation syndrome by Zhengping Huang, Kailey E. Brodeur, Liang Chen, Du, Holly Wobma, Evan E. Hsu, Meng Liu, Joyce C. Chang, Margaret H. Chang, Janet Chou, Megan Day-Lewis, Fatma Dedeoglu, Olha Halyabar, James A. Lederer, Tianwang Li, Mindy S. Lo, Meiping Lu, Esra Meidan, Jane W. Newburger, Adrienne G. Randolph, Mary Beth Son, Robert P. Sundel, Maria L. Taylor, Huaxiang Wu, Qing Zhou, Scott W. Canna, Kevin Wei, Lauren A. Henderson, Peter A. Nigrovic, Pui Y. Lee

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