James R. Downing

--> | birth_place = Detroit, Michigan | death_date = | death_place = | education = University of Michigan–Dearborn
University of Michigan (MD) | workplaces = St. Jude Children's Research Hospital | partner = Mariea Downing | children = 3 }}

James R. Downing is an American clinical executive. He is the president and chief executive officer of St. Jude Children's Research Hospital. Provided by Wikipedia
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  1. 1
    Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts

    Knockdown of Hnrnpa0, a del(5q) gene, alters myeloid cell fate in murine cells through regulation of AU-rich transcripts by David J. Young, Angela Stoddart, Joy Nakitandwe, Shann-Ching Chen, Zhijian Qian, James R. Downing, Michelle M. Le Beau

    Published 2014-06-01
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  2. 2
    Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs.

    Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs. by Deborah French, Wenjian Yang, Leo H Hamilton, Geoffrey Neale, Yiping Fan, James R Downing, Nancy J Cox, Ching-Hon Pui, William E Evans, Mary V Relling

    Published 2008-05-01
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  3. 3
    Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.

    Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. by Utpal P Davé, Keiko Akagi, Rati Tripathi, Susan M Cleveland, Mary A Thompson, Ming Yi, Robert Stephens, James R Downing, Nancy A Jenkins, Neal G Copeland

    Published 2009-05-01
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  4. 4
    Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias.

    Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. by Benjamin J Huang, Anica M Wandler, Lauren K Meyer, Monique Dail, Anneleen Daemen, Deepak Sampath, Qing Li, Xinyue Wang, Jasmine C Wong, Joy Nakitandwe, James R Downing, Jinghui Zhang, Barry S Taylor, Kevin Shannon

    Published 2019-06-01
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  5. 5
    The neoepitope landscape in pediatric cancers

    The neoepitope landscape in pediatric cancers by Ti-Cheng Chang, Robert A. Carter, Yongjin Li, Yuxin Li, Hong Wang, Michael N. Edmonson, Xiang Chen, Paula Arnold, Terrence L. Geiger, Gang Wu, Junmin Peng, Michael Dyer, James R. Downing, Douglas R. Green, Paul G. Thomas, Jinghui Zhang

    Published 2017-08-01
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  6. 6
    Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

    Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis by Jasmine C Wong, Kelley M Weinfurtner, Maria del pilar Alzamora, Scott C Kogan, Michael R Burgess, Yan Zhang, Joy Nakitandwe, Jing Ma, Jinjun Cheng, Shann-Ching Chen, Theodore T Ho, Johanna Flach, Damien Reynaud, Emmanuelle Passegué, James R Downing, Kevin Shannon

    Published 2015-07-01
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  7. 7
    An unexpected protein interaction promotes drug resistance in leukemia

    An unexpected protein interaction promotes drug resistance in leukemia by Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz

    Published 2017-11-01
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  8. 8
    CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data

    CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data by Liqing Tian, Yongjin Li, Michael N. Edmonson, Xin Zhou, Scott Newman, Clay McLeod, Andrew Thrasher, Yu Liu, Bo Tang, Michael C. Rusch, John Easton, Jing Ma, Eric Davis, Austyn Trull, J. Robert Michael, Karol Szlachta, Charles Mullighan, Suzanne J. Baker, James R. Downing, David W. Ellison, Jinghui Zhang

    Published 2020-05-01
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  9. 9
    De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia

    De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia by Axel Hyrenius-Wittsten, Mattias Pilheden, Helena Sturesson, Jenny Hansson, Michael P. Walsh, Guangchun Song, Julhash U. Kazi, Jian Liu, Ramprasad Ramakrishan, Cristian Garcia-Ruiz, Stephanie Nance, Pankaj Gupta, Jinghui Zhang, Lars Rönnstrand, Anne Hultquist, James R. Downing, Karin Lindkvist-Petersson, Kajsa Paulsson, Marcus Järås, Tanja A. Gruber, Jing Ma, Anna K. Hagström-Andersson

    Published 2018-05-01
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  10. 10
    Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations

    Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations by Samuel W. Brady, Yanling Liu, Xiaotu Ma, Alexander M. Gout, Kohei Hagiwara, Xin Zhou, Jian Wang, Michael Macias, Xiaolong Chen, John Easton, Heather L. Mulder, Michael Rusch, Lu Wang, Joy Nakitandwe, Shaohua Lei, Eric M. Davis, Arlene Naranjo, Cheng Cheng, John M. Maris, James R. Downing, Nai-Kong V. Cheung, Michael D. Hogarty, Michael A. Dyer, Jinghui Zhang

    Published 2020-10-01
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  11. 11
    Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)

    Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL) by Timothy I. Shaw, Li Dong, Liqing Tian, Chenxi Qian, Yu Liu, Bensheng Ju, Anthony High, Kanisha Kavdia, Vishwajeeth R. Pagala, Bridget Shaner, Deqing Pei, John Easton, Laura J. Janke, Shaina N. Porter, Xiaotu Ma, Cheng Cheng, Shondra M. Pruett-Miller, John Choi, Jiyang Yu, Junmin Peng, Wei Gu, A. Thomas Look, James R. Downing, Jinghui Zhang

    Published 2021-03-01
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  12. 12
    Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

    Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma by Xiang Chen, Armita Bahrami, Alberto Pappo, John Easton, James Dalton, Erin Hedlund, David Ellison, Sheila Shurtleff, Gang Wu, Lei Wei, Matthew Parker, Michael Rusch, Panduka Nagahawatte, Jianrong Wu, Shenghua Mao, Kristy Boggs, Heather Mulder, Donald Yergeau, Charles Lu, Li Ding, Michael Edmonson, Chunxu Qu, Jianmin Wang, Yongjin Li, Fariba Navid, Najat C. Daw, Elaine R. Mardis, Richard K. Wilson, James R. Downing, Jinghui Zhang, Michael A. Dyer

    Published 2014-04-01
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  13. 13
    Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

    Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome by Michael Rusch, Joy Nakitandwe, Sheila Shurtleff, Scott Newman, Zhaojie Zhang, Michael N. Edmonson, Matthew Parker, Yuannian Jiao, Xiaotu Ma, Yanling Liu, Jiali Gu, Michael F. Walsh, Jared Becksfort, Andrew Thrasher, Yongjin Li, James McMurry, Erin Hedlund, Aman Patel, John Easton, Donald Yergeau, Bhavin Vadodaria, Ruth G. Tatevossian, Susana Raimondi, Dale Hedges, Xiang Chen, Kohei Hagiwara, Rose McGee, Giles W. Robinson, Jeffery M. Klco, Tanja A. Gruber, David W. Ellison, James R Downing, Jinghui Zhang

    Published 2018-09-01
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  14. 14
    MYCN amplification and ATRX mutations are incompatible in neuroblastoma

    MYCN amplification and ATRX mutations are incompatible in neuroblastoma by Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Elizabeth Stewart, Xin Zhou, Jongrye Jeon, Lyra Griffiths, Rosa Nguyen, Jackie Norrie, John Easton, Heather Mulder, Donald Yergeau, Yanling Liu, Jianrong Wu, Collin Van Ryn, Arlene Naranjo, Michael D. Hogarty, Marcin M. Kamiński, Marc Valentine, Shondra M. Pruett-Miller, Alberto Pappo, Jinghui Zhang, Michael R. Clay, Armita Bahrami, Peter Vogel, Seungjae Lee, Anang Shelat, Jay F. Sarthy, Michael P. Meers, Rani E. George, Elaine R. Mardis, Richard K. Wilson, Steven Henikoff, James R. Downing, Michael A. Dyer

    Published 2020-02-01
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