Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection by Christine E. Peters, Jan E. Carette

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A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB. by Clarissa C Lee, Jan E Carette, Thijn R Brummelkamp, Hidde L Ploegh

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Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens. by Bhaven B Patel, Andres M Lebensohn, Ganesh V Pusapati, Jan E Carette, Julia Salzman, Rajat Rohatgi

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Differential and convergent utilization of autophagy components by positive-strand RNA viruses. by Emma Abernathy, Roberto Mateo, Karim Majzoub, Nick van Buuren, Sara W Bird, Jan E Carette, Karla Kirkegaard

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Loquacious modulates flaviviral RNA replication in mosquito cells. by Shwetha Shivaprasad, Kuo-Feng Weng, Yaw Shin Ooi, Julia Belk, Jan E Carette, Ryan Flynn, Peter Sarnow

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DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes by Jennifer H. Lumb, Qin Li, Lauren M. Popov, Siyuan Ding, Marie T. Keith, Bryan D. Merrill, Harry B. Greenberg, Jin Billy Li, Jan E. Carette

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Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus by Jim Baggen, Hendrik Jan Thibaut, Daniel L. Hurdiss, Maryam Wahedi, Caleb D. Marceau, Arno L. W. van Vliet, Jan E. Carette, Frank J. M. van Kuppeveld

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Conserved Oligomeric Golgi (COG) Complex Proteins Facilitate Orthopoxvirus Entry, Fusion and Spread by Susan Realegeno, Lalita Priyamvada, Amrita Kumar, Jessica B. Blackburn, Claire Hartloge, Andreas S. Puschnik, Suryaprakash Sambhara, Victoria A. Olson, Jan E. Carette, Vladimir Lupashin, Panayampalli Subbian Satheshkumar

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A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles by Esther Ndungo, Andrew S. Herbert, Matthijs Raaben, Gregor Obernosterer, Rohan Biswas, Emily Happy Miller, Ariel S. Wirchnianski, Jan E. Carette, Thijn R. Brummelkamp, Sean P. Whelan, John M. Dye, Kartik Chandran

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Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells by Walter W. Chen, Kıvanç Birsoy, Maria M. Mihaylova, Harriet Snitkin, Iwona Stasinski, Burcu Yucel, Erol C. Bayraktar, Jan E. Carette, Clary B. Clish, Thijn R. Brummelkamp, David D. Sabatini, David M. Sabatini

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R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling by Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi

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Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3 by Christine E. Peters, Ursula Schulze-Gahmen, Manon Eckhardt, Gwendolyn M. Jang, Jiewei Xu, Ernst H. Pulido, Conner Bardine, Charles S. Craik, Melanie Ott, Or Gozani, Kliment A. Verba, Ruth Hüttenhain, Jan E. Carette, Nevan J. Krogan

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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome by Peter Tsvetkov, Marc L Mendillo, Jinghui Zhao, Jan E Carette, Parker H Merrill, Domagoj Cikes, Malini Varadarajan, Ferdy R van Diemen, Josef M Penninger, Alfred L Goldberg, Thijn R Brummelkamp, Sandro Santagata, Susan Lindquist

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STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection by Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F. Brulois, Linda L. Yasukawa, Xingnan Li, Calvin J. Kuo, David A. Solomon, Jan E. Carette, Harry B. Greenberg

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Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling by Andres M Lebensohn, Ramin Dubey, Leif R Neitzel, Ofelia Tacchelly-Benites, Eungi Yang, Caleb D Marceau, Eric M Davis, Bhaven B Patel, Zahra Bahrami-Nejad, Kyle J Travaglini, Yashi Ahmed, Ethan Lee, Jan E Carette, Rajat Rohatgi

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A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells by Benjamin G Gowen, Bryan Chim, Caleb D Marceau, Trever T Greene, Patrick Burr, Jeanmarie R Gonzalez, Charles R Hesser, Peter A Dietzen, Teal Russell, Alexandre Iannello, Laurent Coscoy, Charles L Sentman, Jan E Carette, Stefan A Muljo, David H Raulet

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Nuclear accumulation of host transcripts during Zika Virus Infection. by Kristoffer E Leon, Mir M Khalid, Ryan A Flynn, Krystal A Fontaine, Thong T Nguyen, G Renuka Kumar, Camille R Simoneau, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia Kaye, Priya S Shah, Steven Finkbeiner, Nevan J Krogan, Carolyn Bertozzi, Jan E Carette, Melanie Ott

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TMEM41B and VMP1 modulate cellular lipid and energy metabolism for facilitating dengue virus infection. by Meisam Yousefi, Wai Suet Lee, Biaoguo Yan, Liang Cui, Cythia Lingli Yong, Xin Yap, Kwan Sing Leona Tay, Wenjie Qiao, Dewei Tan, Nur Insyirah Nurazmi, Martin Linster, Gavin J D Smith, Yie Hou Lee, Jan E Carette, Eng Eong Ooi, Kuan Rong Chan, Yaw Shin Ooi

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Honey bee Royalactin unlocks conserved pluripotency pathway in mammals by Derrick C. Wan, Stefanie L. Morgan, Andrew L. Spencley, Natasha Mariano, Erin Y. Chang, Gautam Shankar, Yunhai Luo, Ted H. Li, Dana Huh, Star K. Huynh, Jasmine M. Garcia, Cole M. Dovey, Jennifer Lumb, Ling Liu, Katharine V. Brown, Abel Bermudez, Richard Luong, Hong Zeng, Victoria L. Mascetti, Sharon J. Pitteri, Jordon Wang, Hua Tu, Marco Quarta, Vittorio Sebastiano, Roel Nusse, Thomas A. Rando, Jan E. Carette, J. Fernando Bazan, Kevin C. Wang

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Autoantibodies are highly prevalent in non–SARS-CoV-2 respiratory infections and critical illness by Allan Feng, Emily Y. Yang, Andrew Reese Moore, Shaurya Dhingra, Sarah Esther Chang, Xihui Yin, Ruoxi Pi, Elisabeth K.M. Mack, Sara Völkel, Reinhard Geßner, Margrit Gündisch, Andreas Neubauer, Harald Renz, Sotirios Tsiodras, Paraskevi C. Fragkou, Adijat A. Asuni, Joseph E. Levitt, Jennifer G. Wilson, Michelle Leong, Jennifer H. Lumb, Rong Mao, Kassandra Pinedo, Jonasel Roque, Christopher M. Richards, Mikayla Stabile, Gayathri Swaminathan, Maria L. Salagianni, Vasiliki Triantafyllia, Wilhelm Bertrams, Catherine A. Blish, Jan E. Carette, Jennifer Frankovich, Eric Meffre, Kari Christine Nadeau, Upinder Singh, Taia T. Wang, Eline T. Luning Prak, Susanne Herold, Evangelos Andreakos, Bernd Schmeck, Chrysanthi Skevaki, Angela J. Rogers, Paul J. Utz

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