Embedded Wireless Sensor for In Situ Concrete Internal Relative Humidity Monitoring by Tai Ikumi, Ignasi Cairó, Jan Groeneveld, Antonio Aguado, Albert de la Fuente

Get full text

Inflammatory plasma biomarkers in subjects with preclinical Alzheimer’s disease by Samantha Prins, Marieke L. de Kam, Charlotte E. Teunissen, Geert Jan Groeneveld

Get full text

A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly... by Hemme J. Hijma, Emilie M. J. vanBrummelen, Pieter S. Siebenga, Geert Jan Groeneveld

Get full text

Targeting for Success: Demonstrating Proof-of-Concept with Mechanistic Early Phase Clinical Pharmacology Studies for Disease-Modification in Neurodegenerative Disorders by Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld

Get full text

Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds by Igor Radanovic, Igor Radanovic, Naomi Klarenbeek, Robert Rissmann, Robert Rissmann, Geert Jan Groeneveld, Geert Jan Groeneveld, Emilie M. J. van Brummelen, Matthijs Moerland, Matthijs Moerland, Jacobus J. Bosch, Jacobus J. Bosch

Get full text

Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects by Pieter Siebenga, Guido vanAmerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt, Geert Jan Groeneveld

Get full text

Machine Learning Techniques for Developing Remotely Monitored Central Nervous System Biomarkers Using Wearable Sensors: A Narrative Literature Review by Ahnjili ZhuParris, Annika A. de Goede, Iris E. Yocarini, Wessel Kraaij, Geert Jan Groeneveld, Robert Jan Doll

Get full text

False negatives in GBA1 sequencing due to polymerase dependent allelic imbalance by Jonas M. den Heijer, Arnoud Schmitz, Peter Lansbury, Valerie C. Cullen, Dana C. Hilt, Vincenzo Bonifati, Geert Jan Groeneveld

Get full text

Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study by Titia Q. Ruijs, Ingrid W. Koopmans, Marieke L. deKam, Martijn R. Tannemaat, Geert Jan Groeneveld, Jules A. A. C. Heuberger

Get full text

Objective Monitoring of Facioscapulohumeral Dystrophy During Clinical Trials Using a Smartphone App and Wearables: Observational Study by Ghobad Maleki, Ahnjili Zhuparris, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Adam Cohen, Emilie van Brummelen, Geert Jan Groeneveld, Joris De Maeyer

Get full text

EEG machine learning for accurate detection of cholinergic intervention and Alzheimer’s disease by Sonja Simpraga, Ricardo Alvarez-Jimenez, Huibert D. Mansvelder, Joop M. A. van Gerven, Geert Jan Groeneveld, Simon-Shlomo Poil, Klaus Linkenkaer-Hansen

Get full text

First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator by Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld

Get full text

A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls by Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Diana R. Pereira, | Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez

Get full text

Safety, pharmacokinetics, and pharmacodynamics of Gln‐1062, a prodrug of galantamine by Charlotte Bakker, Jasper van derAart, Ellen P. Hart, Erica S. Klaassen, Kirsten R. Bergmann, Michiel J. vanEsdonk, Denis G. Kay, Geert Jan Groeneveld

Get full text

Smartphone and Wearable Sensors for the Estimation of Facioscapulohumeral Muscular Dystrophy Disease Severity: Cross-sectional Study by Ahnjili Zhuparris, Ghobad Maleki, Ingrid Koopmans, Robert J Doll, Nicoline Voet, Wessel Kraaij, Adam Cohen, Emilie van Brummelen, Joris H De Maeyer, Geert Jan Groeneveld

Get full text

Kinetics of myelin breakdown products: A labeling study in patients with progressive multiple sclerosis by Kawita M. S. Kanhai, Sebastiaan C. Goulooze, Jeroen van derGrond, Amy C. Harms, Thomas Hankemeier, Ajay Verma, Gersham Dent, Juan Chavez, Henri Meijering, Geert Jan Groeneveld

Get full text

Utility of Animal Models to Understand Human Alzheimer’s Disease, Using the Mastermind Research Approach to Avoid Unnecessary Further Sacrifices of Animals by Tian Qin, Samantha Prins, Geert Jan Groeneveld, Gerard Van Westen, Helga E. de Vries, Yin Cheong Wong, Luc J.M. Bischoff, Elizabeth C.M. de Lange

Get full text

Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis by Boudewijn T. H. M. Sleutjes, Diederik J. L. Stikvoort García, Maria O. Kovalchuk, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Hessel Franssen, Leonard H. van denBerg

Get full text

Methylphenidate and galantamine in patients with vascular cognitive impairment–the proof-of-principle study STREAM-VCI by Jolien F. Leijenaar, Geert Jan Groeneveld, Erica S. Klaassen, Anna E. Leeuwis, Philip Scheltens, Henry C. Weinstein, Joop M. A. van Gerven, Frederik Barkhof, Wiesje M. van der Flier, Niels D. Prins

Get full text

A smartphone- and wearable-based biomarker for the estimation of unipolar depression severity by Ahnjili Zhuparris, Ghobad Maleki, Liesbeth van Londen, Ingrid Koopmans, Vincent Aalten, Iris E. Yocarini, Vasileios Exadaktylos, Albert van Hemert, Adam Cohen, Pim Gal, Robert-Jan Doll, Geert Jan Groeneveld, Gabriël Jacobs, Wessel Kraaij

Get full text