Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health by María Björk Birkisdóttir, María Björk Birkisdóttir, María Björk Birkisdóttir, Lisanne J. Van’t Sant, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Wilbert P. Vermeij, Dick Jaarsma

Get full text

Gene expression changes in cerebellum induced by dietary restriction by Lisanne J. van’t Sant, María B. Birkisdóttir, María B. Birkisdóttir, María B. Birkisdóttir, Rutger A. Ozinga, Rutger A. Ozinga, Ákos Gyenis, Jan H.J. Hoeijmakers, Jan H.J. Hoeijmakers, Jan H.J. Hoeijmakers, Jan H.J. Hoeijmakers, Wilbert P. Vermeij, Wilbert P. Vermeij, Dick Jaarsma

Get full text

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development. by Hannes Lans, Jurgen A Marteijn, Björn Schumacher, Jan H J Hoeijmakers, Gert Jansen, Wim Vermeulen

Get full text

Fasting Intervention for Children With Unilateral Renal Tumors to Reduce Toxicity by Christiaan A. J. Oudmaijer, Christiaan A. J. Oudmaijer, Winnie M. C. van den Boogaard, Winnie M. C. van den Boogaard, Daphne S. J. Komninos, Daphne S. J. Komninos, Emma J. Verwaaijen, Hanneke M. van Santen, Hanneke M. van Santen, Marc R. Lilien, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Marc H. W. Wijnen, Marry M. van den Heuvel-Eibrink, Wilbert P. Vermeij, Wilbert P. Vermeij

Get full text

In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration by Lisanne J. van’t Sant, Joshua J. White, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma

Get full text

Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside by María B. Birkisdóttir, María B. Birkisdóttir, Ivar van Galen, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Pier G. Mastroberardino, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij, Wilbert P. Vermeij

Get full text

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside by María B. Birkisdóttir, María B. Birkisdóttir, Ivar van Galen, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Pier G. Mastroberardino, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij, Wilbert P. Vermeij

Get full text

Decreased hepatic thyroid hormone signaling in systemic and liver-specific but not brain-specific accelerated aging due to DNA repair deficiency in mice by Sander Barnhoorn, Marcel E Meima, Robin P Peeters, Veerle M Darras, Selmar Leeuwenburgh, Jan H J Hoeijmakers, Wilbert P Vermeij, W Edward Visser

Get full text

DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1 by Cristina Ribeiro-Silva, Özge Z. Aydin, Raquel Mesquita-Ribeiro, Jana Slyskova, Angela Helfricht, Jurgen A. Marteijn, Jan H. J. Hoeijmakers, Hannes Lans, Wim Vermeulen

Get full text

Dynamic interaction of TTDA with TFIIH is stabilized by nucleotide excision repair in living cells. by Giuseppina Giglia-Mari, Giuseppina Giglia-Mari, Catherine Miquel, Arjan F Theil, Pierre-Olivier Mari, Deborah Hoogstraten, Jessica M Y Ng, Christoffel Dinant, Jan H J Hoeijmakers, Wim Vermeulen

Get full text

A Sample Preparation Method for the Simultaneous Profiling of Signaling Lipids and Polar Metabolites in Small Quantities of Muscle Tissues from a Mouse Model for Sarcopenia by Yupeng He, Marlien van Mever, Wei Yang, Luojiao Huang, Rawi Ramautar, Yvonne Rijksen, Wilbert P. Vermeij, Jan H. J. Hoeijmakers, Amy C. Harms, Peter W. Lindenburg, Thomas Hankemeier

Get full text

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients. by Anwaar Ahmad, Jacqueline H Enzlin, Nikhil R Bhagwat, Nils Wijgers, Anja Raams, Esther Appledoorn, Arjan F Theil, Jan H J Hoeijmakers, Wim Vermeulen, Nicolaas G J Jaspers, Orlando D Schärer, Laura J Niedernhofer

Get full text

Disruption of TTDA results in complete nucleotide excision repair deficiency and embryonic lethality. by Arjan F Theil, Julie Nonnekens, Barbara Steurer, Pierre-Olivier Mari, Jan de Wit, Charlène Lemaitre, Jurgen A Marteijn, Anja Raams, Alex Maas, Marcel Vermeij, Jeroen Essers, Jan H J Hoeijmakers, Giuseppina Giglia-Mari, Wim Vermeulen

Get full text

Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer. by Kishan A T Naipal, Anja Raams, Serena T Bruens, Inger Brandsma, Nicole S Verkaik, Nicolaas G J Jaspers, Jan H J Hoeijmakers, Geert J L H van Leenders, Joris Pothof, Roland Kanaar, Joost Boormans, Dik C van Gent

Get full text

Differentiation driven changes in the dynamic organization of Basal transcription initiation. by Giuseppina Giglia-Mari, Giuseppina Giglia-Mari, Arjan F Theil, Pierre-Olivier Mari, Sophie Mourgues, Julie Nonnekens, Lise O Andrieux, Jan de Wit, Catherine Miquel, Nils Wijgers, Alex Maas, Maria Fousteri, Jan H J Hoeijmakers, Wim Vermeulen

Get full text

Correction: Adaptive Stress Response in Segmental Progeria Resembles Long-Lived Dwarfism and Calorie Restriction in Mice. by Marieke van de Ven, Jaan-Olle Andressoo, Valerie B Holcomb, Marieke von Lindern, Willeke M. C Jong, Chris I. De Zeeuw, Yousin Suh, Paul Hasty, Jan H. J Hoeijmakers, Gijsbertus T. J van der Horst, James R Mitchell

Get full text

Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. by Marieke van de Ven, Jaan-Olle Andressoo, Valerie B Holcomb, Marieke von Lindern, Willeke M C Jong, Chris I De Zeeuw, Yousin Suh, Paul Hasty, Jan H J Hoeijmakers, Gijsbertus T J van der Horst, James R Mitchell

Get full text

Inefficient DNA Repair Is an Aging-Related Modifier of Parkinson’s Disease by Sara Sepe, Chiara Milanese, Sylvia Gabriels, Kasper W.J. Derks, Cesar Payan-Gomez, Wilfred F.J. van IJcken, Yvonne M.A. Rijksen, Alex L. Nigg, Sandra Moreno, Silvia Cerri, Fabio Blandini, Jan H.J. Hoeijmakers, Pier G. Mastroberardino

Get full text

Age-related skeletal dynamics and decrease in bone strength in DNA repair deficient male trichothiodystrophy mice. by Claudia Nicolaije, Karin E M Diderich, S M Botter, Matthias Priemel, Jan H Waarsing, Judd S Day, Renata M C Brandt, Arndt F Schilling, Harrie Weinans, Bram C Van der Eerden, Gijsbertus T J van der Horst, Jan H J Hoeijmakers, Johannes P T M van Leeuwen

Get full text

Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency. by Sander Barnhoorn, Lieneke M Uittenboogaard, Dick Jaarsma, Wilbert P Vermeij, Maria Tresini, Michael Weymaere, Hervé Menoni, Renata M C Brandt, Monique C de Waard, Sander M Botter, Altaf H Sarker, Nicolaas G J Jaspers, Gijsbertus T J van der Horst, Priscilla K Cooper, Jan H J Hoeijmakers, Ingrid van der Pluijm

Get full text