ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML. by Marta E Capala, Edo Vellenga, Jan Jacob Schuringa

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Convergence of hypoxia and TGFβ pathways on cell cycle regulation in human hematopoietic stem/progenitor cells. by Albertus T J Wierenga, Edo Vellenga, Jan Jacob Schuringa

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P1345: EFFECT OF DECITABINE ON MACROPHAGE PHENOTYPE AND FUNCTION IN VITRO IN THE CONTEXT OF AML by Jacobien Hilberink, Isabel Weinhäuser, Diego Pereira-Martins, Jan Jacob Schuringa, Gerwin Huls

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BRD3/4 inhibition and FLT3-ligand deprivation target pathways that are essential for the survival of human MLL-AF9+ leukemic cells. by Marco Carretta, Annet Z Brouwers-Vos, Matthieu Bosman, Sarah J Horton, Joost H A Martens, Edo Vellenga, Jan Jacob Schuringa

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Signal regulatory protein beta 2 is a novel positive regulator of innate anticancer immunity by Nienke Visser, Levi Collin Nelemans, Yuan He, Harm Jan Lourens, Macarena González Corrales, Gerwin Huls, Valerie R. Wiersma, Jan Jacob Schuringa, Edwin Bremer

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Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation. by Pallavi Sontakke, Katarzyna M Koczula, Jennifer Jaques, Albertus T J Wierenga, Annet Z Brouwers-Vos, Maurien Pruis, Ulrich L Günther, Edo Vellenga, Jan Jacob Schuringa

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High <i>ME1</i> Expression Is a Molecular Predictor of Post-Transplant Survival of Patients with Acute Myeloid Leukemia by César Alexander Ortiz Rojas, Abel Costa-Neto, Diego A. Pereira-Martins, Duy Minh Le, Dominique Sternadt, Isabel Weinhäuser, Gerwin Huls, Jan Jacob Schuringa, Eduardo Magalhães Rego

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Unraveling Hematotoxicity of α-Amanitin in Cultured Hematopoietic Cells by Willemien F. J. Hof, Miranda Visser, Joyce J. de Jong, Marian N. Rajasekar, Jan Jacob Schuringa, Inge A. M. de Graaf, Daan J. Touw, Bart G. J. Dekkers

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Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock by Maria Azkanaz, Aida Rodríguez López, Bauke de Boer, Wouter Huiting, Pierre-Olivier Angrand, Edo Vellenga, Harm H Kampinga, Steven Bergink, Joost HA Martens, Jan Jacob Schuringa, Vincent van den Boom

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Clonal Hematopoiesis Defined by Somatic Mutations Infrequently Co-occurs With Mosaic Loss of the Y Chromosome in a Population-based Cohort by Priscilla Kamphuis, Isabelle A. van Zeventer, Aniek O. de Graaf, Giulio Genovese, Jonas B. Salzbrunn, Avinash G. Dinmohamed, Bert A. van der Reijden, Jan Jacob Schuringa, Joop H. Jansen, Gerwin Huls

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HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells by Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa

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The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem ce... by Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens

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VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses by Yusheng Lin, Ghizlane Choukrani, Lena Dubbel, Lena Rockstein, Jimena Alvarez Freile, Yuzhu Qi, Valerie Wiersma, Hao Zhang, Karl-Wilhelm Koch, Emanuele Ammatuna, Jan Jacob Schuringa, Tom van Meerten, Gerwin Huls, Edwin Bremer

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P466: THE INTRINSICALLY DISORDERED TRANSCRIPTIONAL REGULATOR MN1 DEPENDS ON THE CHAPERONE DNAJB6B FOR ITS FULL TRANSFORMING POTENTIAL by Diego A Pereira-Martins, Vincent van den Boom, Noortje van Dijk, Isabel Weinhauser, Douglas Silveira, Thiago M Bianco, César Alexander Ortiz Rojas, Gerwin Huls, Lynn Quek, Antonio R Lucena-Araujo, Eduardo Rego, Jan Jacob Schuringa

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Sex Differences in the Spectrum of Clonal Hematopoiesis by Priscilla Kamphuis, Isabelle A. van Zeventer, Aniek O. de Graaf, Jonas B. Salzbrunn, Maaike G. J. M. van Bergen, Avinash G. Dinmohamed, Bert A. van der Reijden, Jan Jacob Schuringa, Joop H. Jansen, Gerwin Huls

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Abnormal Platelet Counts and Clonal Hematopoiesis in the General Population by Priscilla Kamphuis, Maaike G.J.M. van Bergen, Isabelle A. van Zeventer, Aniek O. de Graaf, Avinash G. Dinmohamed, Jonas B. Salzbrunn, Jan Jacob Schuringa, Bert A. van der Reijden, Gerwin Huls, Joop H. Jansen

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Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability by Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa

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Pharmacological Inhibition of PIP4K2 Potentiates Venetoclax-Induced Apoptosis in Acute Myeloid Leukemia by Keli Lima, Maria Fernanda Lopes Carvalho, Diego Antonio Pereira-Martins, Frederico Lisboa Nogueira, Lívia Bassani Lins de Miranda, Mariane Cristina do Nascimento, Rita de Cássia Cavaglieri, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo Magalhães Rego

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S127: DELTATP73 IMPOSES TP53 MUTANT-LIKE PHENOTYPES INCLUDING DRUG RESISTANCE AND POOR PROGNOSIS ON TP53-WILD TYPE ACUTE MYELOID LEUKEMIA. by Diego A Pereira-Martins, César Alexander Ortiz Rojas, Isabel Weinhauser, Douglas Silveira, Albertus T J Wierenga, Vincent van den Boom, Thiago M Bianco, Emanuele Ammatuna, Lynn Quek, Antonio R Lucena-Araujo, Gerwin Huls, Eduardo Rego, Jan Jacob Schuringa

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MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model by Diego A. Pereira-Martins, Isabel Weinhäuser, Juan Luiz Coelho-Silva, Pedro L. França-Neto, Luciana Y. Almeida, Thiago M. Bianco, Cleide L. Silva, Rafael F. França, Fabiola Traina, Eduardo M. Rego, Jan Jacob Schuringa, Antonio R. Lucena-Araujo

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