BH3 Mimetic Sensitivity of Colorectal Cancer Cell Lines in Correlation with Molecular Features Identifies Predictors of Response by Le Zhang, Prashanthi Ramesh, Maxime Steinmetz, Jan Paul Medema

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Betulin is a potent anti-tumor agent that is enhanced by cholesterol. by Franziska B Mullauer, Jan H Kessler, Jan Paul Medema

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Mouse tissues express multiple splice variants of prominin-1. by Kristel Kemper, Marc J P M Tol, Jan Paul Medema

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The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis by Paris Jabeen Asif, Ciro Longobardi, Michael Hahne, Jan Paul Medema

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CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status. by Jurrit Zeilstra, Sander P J Joosten, Louis Vermeulen, Jan Koster, Jan Paul Medema, Rogier Versteeg, Marcel Spaargaren, Steven T Pals

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Systemic effects of angiogenesis inhibition alter pharmacokinetics and intratumoral delivery of nab-paclitaxel by Anne Steins, Eva A. Ebbing, Marcel C. M. Pistorius, Cynthia Waasdorp, Kausilia K. Krishnadath, Jan Paul Medema, Johanna W. Wilmink, Ron A. A. Mathôt, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven

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ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy by Mattheus C.B. Wielenga, Selcuk Colak, Jarom Heijmans, Jooske F. van Lidth de Jeude, Hans M. Rodermond, James C. Paton, Adrienne W. Paton, Louis Vermeulen, Jan Paul Medema, Gijs R. van den Brink

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AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition by Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Arezo Torang, Daniëlle Dekker, Joan H. de Jong, Kate Cameron, Sara Vitale, Giorgio Stassi, Sander R. van Hooff, Mauro A. A. Castro, Louis Vermeulen, Jan Paul Medema

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Correlation of Immunological and Histopathological Features with Gene Expression-Based Classifiers in Colon Cancer Patients by Simone van de Weerd, Marloes A. Smit, Jessica Roelands, Wilma E. Mesker, Davide Bedognetti, Peter J. K. Kuppen, Hein Putter, Rob A. E. M. Tollenaar, Jeanine M. L. Roodhart, Wouter Hendrickx, Jan Paul Medema, J. Han J. M. van Krieken

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The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut by Rana Ramadan, Valérie M. Wouters, Sanne M. van Neerven, Nina E. de Groot, Tania Martins Garcia, Vanessa Muncan, Olivia D. Franklin, Michelle Battle, Karen Sue Carlson, Joshua Leach, Owen J. Sansom, Olivier Boulard, Mathias Chamaillard, Louis Vermeulen, Jan Paul Medema, David J. Huels

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A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer by Federica Francescangeli, Paola Contavalli, Maria Laura De Angelis, Silvia Careccia, Michele Signore, Tobias Longin Haas, Federico Salaris, Marta Baiocchi, Alessandra Boe, Alessandro Giuliani, Olga Tcheremenskaia, Alfredo Pagliuca, Ombretta Guardiola, Gabriella Minchiotti, Lidia Colace, Antonio Ciardi, Vito D’Andrea, Filippo La Torre, JanPaul Medema, Ruggero De Maria, Ann Zeuner

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Serum-based measurements of stromal activation through ADAM12 associate with poor prognosis in colorectal cancer by Sanne ten Hoorn, Cynthia Waasdorp, Martijn G. H. van Oijen, Helene Damhofer, Anne Trinh, Lan Zhao, Lisanne J. H. Smits, Sanne Bootsma, Gabi W. van Pelt, Wilma E. Mesker, Linda Mol, Kaitlyn K. H. Goey, Miriam Koopman, Jan Paul Medema, Jurriaan B. Tuynman, Inti Zlobec, Cornelis J. A. Punt, Louis Vermeulen, Maarten F. Bijlsma

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Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression by Janneke F. Linnekamp, Raju Kandimalla, Evelyn Fessler, Joan H. de Jong, Hans M. Rodermond, Gregor G. W. van Bochove, Frans O. The, Cornelis J. A. Punt, Willem A. Bemelman, Anthony W. H. van de Ven, Pieter J. Tanis, Elles M. Kemper, Lianne Koens, Evelien Dekker, Louis Vermeulen, Hanneke W. M. van Laarhoven, Jan Paul Medema

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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer by Joyce Y. Buikhuisen, Patricia M. Gomez Barila, Kate Cameron, Saskia J. E. Suijkerbuijk, Cor Lieftink, Simone di Franco, Ana Krotenberg Garcia, Rebeca Uceda Castro, Kristiaan J. Lenos, Lisanne E. Nijman, Arezo Torang, Ciro Longobardi, Joan H. de Jong, Daniëlle Dekker, Giorgio Stassi, Louis Vermeulen, Roderick L. Beijersbergen, Jacco van Rheenen, Stephan Huveneers, Jan Paul Medema

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Rapid stromal remodeling by short‐term VEGFR2 inhibition increases chemotherapy delivery in esophagogastric adenocarcinoma by Anne Steins, Remy Klaassen, Igor Jacobs, Matthias C. Schabel, Monique G. J. T. B. vanLier, Eva A. Ebbing, Stefanie J. Hectors, Sander W. Tas, Chrissta X. Maracle, Cornelis J. A. Punt, Maria Siebes, Jacques J. G. H. M. Bergman, Jan Paul Medema, Johanna W. Wilmink, Ron A. A. Mathot, Gustav J. Strijkers, Maarten F. Bijlsma, Hanneke W. M. vanLaarhoven

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Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery by Simone Di Franco, Paola Bianca, Davide Stefano Sardina, Alice Turdo, Miriam Gaggianesi, Veronica Veschi, Annalisa Nicotra, Laura Rosa Mangiapane, Melania Lo Iacono, Irene Pillitteri, Sander van Hooff, Federica Martorana, Gianmarco Motta, Eliana Gulotta, Vincenzo Luca Lentini, Emanuele Martorana, Micol Eleonora Fiori, Salvatore Vieni, Maria Rita Bongiorno, Giorgio Giannone, Dario Giuffrida, Lorenzo Memeo, Lorenzo Colarossi, Marzia Mare, Paolo Vigneri, Matilde Todaro, Ruggero De Maria, Jan Paul Medema, Giorgio Stassi

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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis by Joshua D. G. Leach, Nikola Vlahov, Petros Tsantoulis, Rachel A. Ridgway, Dustin J. Flanagan, Kathryn Gilroy, Nathalie Sphyris, Ester G. Vázquez, David F. Vincent, William J. Faller, Michael C. Hodder, Alexander Raven, Sigrid Fey, Arafath K. Najumudeen, Douglas Strathdee, Colin Nixon, Mark Hughes, William Clark, Robin Shaw, S:CORT consortium, Sander R. van Hooff, David J. Huels, Jan Paul Medema, Simon T. Barry, Margaret C. Frame, Asier Unciti-Broceta, Simon J. Leedham, Gareth J. Inman, Rene Jackstadt, Barry J. Thompson, Andrew D. Campbell, Sabine Tejpar, Owen J. Sansom

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Molecular characterization of colorectal cancer related peritoneal metastatic disease by Kristiaan J. Lenos, Sander Bach, Leandro Ferreira Moreno, Sanne ten Hoorn, Nina R. Sluiter, Sanne Bootsma, Felipe A. Vieira Braga, Lisanne E. Nijman, Tom van den Bosch, Daniel M. Miedema, Erik van Dijk, Bauke Ylstra, Ruth Kulicke, Fred P. Davis, Nicolas Stransky, Gromoslaw A. Smolen, Robert R. J. Coebergh van den Braak, Jan N. M. IJzermans, John W. M. Martens, Sally Hallam, Andrew D. Beggs, Geert J. P. L. Kops, Nico Lansu, Vivian P. Bastiaenen, Charlotte E. L. Klaver, Maria C. Lecca, Khalid El Makrini, Clara C. Elbers, Mark P. G. Dings, Carel J. M. van Noesel, Onno Kranenburg, Jan Paul Medema, Jan Koster, Lianne Koens, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. de Hingh, Maarten F. Bijlsma, Jurriaan B. Tuynman, Louis Vermeulen

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