scSNPdemux: a sensitive demultiplexing pipeline using single nucleotide polymorphisms for improved pooled single-cell RNA sequencing analysis by John K. L. Wong, Lena Jassowicz, Christel Herold-Mende, Martina Seiffert, Jan-Philipp Mallm, Peter Lichter, Marc Zapatka

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HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing by Ahuvi Yearim, Sahar Gelfman, Ronna Shayevitch, Shai Melcer, Ohad Glaich, Jan-Philipp Mallm, Malka Nissim-Rafinia, Ayelet-Hashahar S. Cohen, Karsten Rippe, Eran Meshorer, Gil Ast

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Specificity, propagation, and memory of pericentric heterochromatin by Katharina Müller‐Ott, Fabian Erdel, Anna Matveeva, Jan‐Philipp Mallm, Anne Rademacher, Matthias Hahn, Caroline Bauer, Qin Zhang, Sabine Kaltofen, Gunnar Schotta, Thomas Höfer, Karsten Rippe

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Differentiation‐related epigenomic changes define clinically distinct keratinocyte cancer subclasses by Llorenç Solé‐Boldo, Günter Raddatz, Julian Gutekunst, Oliver Gilliam, Felix Bormann, Michelle S Liberio, Daniel Hasche, Wiebke Antonopoulos, Jan‐Philipp Mallm, Anke S Lonsdorf, Manuel Rodríguez‐Paredes, Frank Lyko

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Single-nucleus chromatin accessibility reveals intratumoral epigenetic heterogeneity in IDH1 mutant gliomas by Ruslan Al-Ali, Katharina Bauer, Jong-Whi Park, Ruba Al Abdulla, Valentina Fermi, Andreas von Deimling, Christel Herold-Mende, Jan-Philipp Mallm, Carl Herrmann, Wolfgang Wick, Şevin Turcan

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The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability by Jennifer Derrien, Catherine Guérin-Charbonnel, Victor Gaborit, Loïc Campion, Magali Devic, Elise Douillard, Nathalie Roi, Hervé Avet-Loiseau, Olivier Decaux, Thierry Facon, Jan-Philipp Mallm, Roland Eils, Nikhil C. Munshi, Philippe Moreau, Carl Herrmann, Florence Magrangeas, Stéphane Minvielle

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Transplanting rejuvenated blood stem cells extends lifespan of aged immunocompromised mice by Sara Montserrat-Vazquez, Noelle J. Ali, Francesca Matteini, Javier Lozano, Tu Zhaowei, Eva Mejia-Ramirez, Gina Marka, Angelika Vollmer, Karin Soller, Mehmet Sacma, Vadim Sakk, Loris Mularoni, Jan Philipp Mallm, Mireya Plass, Yi Zheng, Hartmut Geiger, M. Carolina Florian

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A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs by Changwen Wang, Meng Sun, Chunxuan Shao, Lisa Schlicker, Yue Zhuo, Yassin Harim, Tianping Peng, Weili Tian, Nadja Stöffler, Martin Schneider, Dominic Helm, Youjun Chu, Beibei Fu, Xiaoliang Jin, Jan-Philipp Mallm, Moritz Mall, Yonghe Wu, Almut Schulze, Hai-Kun Liu

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Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single‐cell transcriptomics by Stephan M. Tirier, Jan-Philipp Mallm, Simon Steiger, Alexandra M. Poos, Mohamed H. S. Awwad, Nicola Giesen, Nicola Casiraghi, Hana Susak, Katharina Bauer, Anja Baumann, Lukas John, Anja Seckinger, Dirk Hose, Carsten Müller-Tidow, Hartmut Goldschmidt, Oliver Stegle, Michael Hundemer, Niels Weinhold, Marc S. Raab, Karsten Rippe

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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL by Justyna A. Wierzbinska, Reka Toth, Naveed Ishaque, Karsten Rippe, Jan-Philipp Mallm, Lara C. Klett, Daniel Mertens, Thorsten Zenz, Thomas Hielscher, Marc Seifert, Ralf Küppers, Yassen Assenov, Pavlo Lutsik, Stephan Stilgenbauer, Philipp M. Roessner, Martina Seiffert, John Byrd, Christopher C. Oakes, Christoph Plass, Daniel B. Lipka

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Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks by Jan‐Philipp Mallm, Murat Iskar, Naveed Ishaque, Lara C Klett, Sabrina J Kugler, Jose M Muino, Vladimir B Teif, Alexandra M Poos, Sebastian Großmann, Fabian Erdel, Daniele Tavernari, Sandra D Koser, Sabrina Schumacher, Benedikt Brors, Rainer König, Daniel Remondini, Martin Vingron, Stephan Stilgenbauer, Peter Lichter, Marc Zapatka, Daniel Mertens, Karsten Rippe

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Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia by Therese Vu, Jasmin Straube, Amy H. Porter, Megan Bywater, Axia Song, Victoria Ling, Leanne Cooper, Gabor Pali, Claudia Bruedigam, Sebastien Jacquelin, Joanne Green, Graham Magor, Andrew Perkins, Alistair M. Chalk, Carl R. Walkley, Florian H. Heidel, Pamela Mukhopadhyay, Nicole Cloonan, Stefan Gröschel, Jan-Philipp Mallm, Stefan Fröhling, Claudia Scholl, Steven W. Lane

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Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage by David R. Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K. Maass, Hanna Schumacher, Piyush Joshi, Maxwell P. Gold, Julia Sundheimer, Britta Statz, Ahmet S. Rifaioglu, Katharina Bauer, Sabrina Schumacher, Michele Bortolomeazzi, Felice Giangaspero, Kati J. Ernst, Steven C. Clifford, Julio Saez-Rodriguez, David T. W. Jones, Daisuke Kawauchi, Ernest Fraenkel, Jan-Philipp Mallm, Karsten Rippe, Andrey Korshunov, Stefan M. Pfister, Kristian W. Pajtler

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ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT by Mark Hartmann, Maximilian Schönung, Jovana Rajak, Joschka Hey, Valentin Maurer, Ling Hai, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Katrin M. Bernt, Roland Roelz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Michael D. Milsom, Stefan Fröhling, Marc-Jan Bonder, Charlotte Niemeyer, Christian Flotho, Christoph Plass, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka

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S206: ONCO-FETAL REPROGRAMMING DRIVES HIGH-RISK JUVENILE MYELOMONOCYTIC LEUKEMIA, WHICH CAN BE TARGETED BY ANTI-CD52 TREATMENT by Mark Hartmann, Maximilian Schönung, Jovana Rajak, Joschka Hey, Valentin Maurer, Ling Hai, Sina Staeble, Jens Langstein, Katharina Bauer, Mariam Hakobyan, Laura Jardine, Sheila Bohler, Dominik Vonficht, Abdul-Habib Maag, Dirk Lebrecht, Kathrin Bernt, Roland Rölz, Tobias Boch, Eleonora Khabirova, Pavlo Lutsik, Simon Haas, Muzlifah Haniffa, Sam Behjati, Jan-Philipp Mallm, Christian Buske, Michael Milsom, Stefan Fröhling, Marc-Jan Bonder, Christoph Plass, Charlotte Niemeyer, Christian Flotho, Miriam Erlacher, Matthias Schlesner, Daniel B. Lipka

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Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level by Lukas John, Alexandra M. Poos, Alexander Brobeil, Carolina Schinke, Stefanie Huhn, Nina Prokoph, Raphael Lutz, Barbara Wagner, Maurizio Zangari, Stephan M. Tirier, Jan-Philipp Mallm, Sabrina Schumacher, Dominik Vonficht, Llorenç Solé-Boldo, Sabine Quick, Simon Steiger, Moritz J. Przybilla, Katharina Bauer, Anja Baumann, Stefan Hemmer, Christoph Rehnitz, Christian Lückerath, Christos Sachpekidis, Gunhild Mechtersheimer, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss, Philipp Reichert, Bart Barlogie, Carsten Müller-Tidow, Hartmut Goldschmidt, Jens Hillengass, Leo Rasche, Simon F. Haas, Frits van Rhee, Karsten Rippe, Marc S. Raab, Sandra Sauer, Niels Weinhold

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