Sudden Cardiac Death due to Coronary Artery Vasculitis in a Patient with Relapsing Polychondritis by Heather Bukiri, Steven M. Ruhoy, Jane H. Buckner

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PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses by Warren Anderson, Fariba Barahmand-pour-Whitman, Peter S Linsley, Karen Cerosaletti, Jane H Buckner, David J Rawlings

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Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune-modifying therapies by Samuel D. Klebanoff, Lauren B. Rodda, Chihiro Morishima, Mark H. Wener, Yevgeniy Yuzefpolskiy, Estelle Bettelli, Jane H. Buckner, Cate Speake, Marion Pepper, Daniel J. Campbell

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Mechanism‐driven strategies for prevention of rheumatoid arthritis by V. Michael Holers, Kristine A. Kuhn, M. Kristen Demoruelle, Jill M. Norris, Gary S. Firestein, Eddie A. James, William H. Robinson, Jane H. Buckner, Kevin D. Deane

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Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes by Jeremy R. B. Newman, S. Alice Long, Cate Speake, Carla J. Greenbaum, Karen Cerosaletti, Stephen S. Rich, Suna Onengut-Gumuscu, Lauren M. McIntyre, Jane H. Buckner, Patrick Concannon

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Crosstalk between CD4 T cells and synovial fibroblasts from human arthritic joints promotes hyaluronan-dependent leukocyte adhesion and inflammatory cytokine expression in vitro by Inkyung Kang, Christian Hundhausen, Stephen P. Evanko, Prasanthi Malapati, Gail Workman, Christina K. Chan, Cliff Rims, Gary S. Firestein, David L. Boyle, Kevin M. MacDonald, Jane H. Buckner, Thomas N. Wight

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IL-6–targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function by Cate Speake, Tania Habib, Katharina Lambert, Christian Hundhausen, Sandra Lord, Matthew J. Dufort, Samuel O. Skinner, Alex Hu, MacKenzie Kinsman, Britta E. Jones, Megan D. Maerz, Megan Tatum, Anne M. Hocking, Gerald T. Nepom, Carla J. Greenbaum, Jane H. Buckner

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SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity by Jillian R. Jaycox, Carolina Lucas, Inci Yildirim, Yile Dai, Eric Y. Wang, Valter Monteiro, Sandra Lord, Jeffrey Carlin, Mariko Kita, Jane H. Buckner, Shuangge Ma, Melissa Campbell, Albert Ko, Saad Omer, Carrie L. Lucas, Cate Speake, Akiko Iwasaki, Aaron M. Ring

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Evaluating associations of joint swelling, joint stiffness and joint pain with physical activity in first-degree relatives of patients with rheumatoid arthritis: Studies of the Aet... by Michael H Weisman, Joachim H Ix, Peter K Gregersen, Jill M Norris, James R ODell, Ted R Mikuls, Kevin D Deane, V Michael Holers, M Kristen Demoruelle, Jane H Buckner, Richard M Keating, Jan M Hughes-Austin, Samuel R Ward

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Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis by Jae-Seung Moon, Shady Younis, Nitya S. Ramadoss, Radhika Iyer, Khushboo Sheth, Orr Sharpe, Navin L. Rao, Stephane Becart, Julie A. Carman, Eddie A. James, Jane H. Buckner, Kevin D. Deane, V. Michael Holers, Susan M. Goodman, Laura T. Donlin, Mark M. Davis, William H. Robinson

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Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted α-Enolase T Cell Epitope in Rheumatoid Arthritis by Christina Gerstner, Anatoly Dubnovitsky, Anatoly Dubnovitsky, Charlotta Sandin, Genadiy Kozhukh, Genadiy Kozhukh, Hannes Uchtenhagen, Hannes Uchtenhagen, Eddie A. James, Johan Rönnelid, Anders Jimmy Ytterberg, Anders Jimmy Ytterberg, Jennifer Pieper, Evan Reed, Karolina Tandre, Mary Rieck, Roman A. Zubarev, Lars Rönnblom, Tatyana Sandalova, Tatyana Sandalova, Jane H. Buckner, Adnane Achour, Adnane Achour, Vivianne Malmström

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The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner by Amanda J. Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D. Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A. Zwingman, Aaron B.I. Rosen, Eric J. Allenspach, Eric J. Allenspach, Kathleen J. Millen, Kathleen J. Millen, Jane H. Buckner, David J. Rawlings, David J. Rawlings, David J. Rawlings, Jacquelyn A. Gorman

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Abatacept increases T cell exhaustion in early RA individuals who carry HLA risk alleles by Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Bernard Ng, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner

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Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis by Susan P. Canny, MD, PhD, Ian B. Stanaway, PhD, Sarah E. Holton, MD, PhD, Mallorie Mitchem, BA, Allison R. O’Rourke, PhD, Stephan Pribitzer, PhD, Sarah K. Baxter, MD, PhD, Mark M. Wurfel, MD, PhD, Uma Malhotra, MD, Jane H. Buckner, MD, Pavan K. Bhatraju, MD, Eric D. Morrell, MD, Cate Speake, PhD, Carmen Mikacenic, MD, Jessica A. Hamerman, PhD

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Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis by Eddie A. James, V. Michael Holers, Radhika Iyer, E. Barton Prideaux, Navin L. Rao, Cliff Rims, Virginia S. Muir, Sylvia E. Posso, Michelle S. Bloom, Amin Zia, Serra E. Elliott, Julia Z. Adamska, Rizi Ai, R. Camille Brewer, Jennifer A. Seifert, LauraKay Moss, Saman Barzideh, M. Kristen Demoruelle, Christopher C. Striebich, Yuko Okamoto, Enkhtsogt Sainbayar, Alexandra A. Crook, Ryan A. Peterson, Lauren A. Vanderlinden, Wei Wang, David L. Boyle, William H. Robinson, Jane H. Buckner, Gary S. Firestein, Kevin D. Deane

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Endomembrane targeting of human OAS1 p46 augments antiviral activity by Frank W Soveg, Johannes Schwerk, Nandan S Gokhale, Karen Cerosaletti, Julian R Smith, Erola Pairo-Castineira, Alison M Kell, Adriana Forero, Shivam A Zaver, Katharina Esser-Nobis, Justin A Roby, Tien-Ying Hsiang, Snehal Ozarkar, Jonathan M Clingan, Eileen T McAnarney, Amy EL Stone, Uma Malhotra, Cate Speake, Joseph Perez, Chiraag Balu, Eric J Allenspach, Jennifer L Hyde, Vineet D Menachery, Saumendra N Sarkar, Joshua J Woodward, Daniel B Stetson, John Kenneth Baillie, Jane H Buckner, Michael Gale Jr, Ram Savan

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IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes by Carla J. Greenbaum, Elisavet Serti, Katharina Lambert, Lia J. Weiner, Sai Kanaparthi, Sandra Lord, Stephen E. Gitelman, Darrell M. Wilson, Jason L. Gaglia, Kurt J. Griffin, William E. Russell, Philip Raskin, Antoinette Moran, Steven M. Willi, Eva Tsalikian, Linda A. DiMeglio, Kevan C. Herold, Wayne V. Moore, Robin Goland, Mark Harris, Maria E. Craig, Desmond A. Schatz, David A. Baidal, Henry Rodriguez, Kristina M. Utzschneider, Hendrik J. Nel, Carol L. Soppe, Karen D. Boyle, Karen Cerosaletti, Lynette Keyes-Elstein, S. Alice Long, Ranjeny Thomas, James G. McNamara, Jane H. Buckner, Srinath Sanda, for the ITN058AI EXTEND Study Team

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