Do We Need Anti-Prion Compounds to Treat Alzheimer’s Disease? by Dieter Willbold, Janine Kutzsche

Get full text

Oral Treatment with <span style="font-variant: small-caps">d</span>-RD2RD2 Impedes Early Disease Mechanisms in SOD1*G93A Transgenic Mice but Does Not Prolong Survival by Katharina Wintz, Julia Post, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsche

Get full text

A Novel Anti-Inflammatory <span style="font-variant: small-caps">d</span>-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model by Julia Post, Vanessa Kogel, Anja Schaffrath, Philipp Lohmann, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsche

Get full text

Sex-Related Motor Deficits in the Tau-P301L Mouse Model by Luana Cristina Camargo, Dominik Honold, Robert Bauer, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit, Sarah Schemmert

Get full text

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease by Janine Kutzsche, Sarah Schemmert, Markus Tusche, Jörg Neddens, Roland Rabl, Dagmar Jürgens, Oleksandr Brener, Antje Willuweit, Birgit Hutter-Paier, Dieter Willbold

Get full text

Deceleration of the neurodegenerative phenotype in pyroglutamate-Aβ accumulating transgenic mice by oral treatment with the Aβ oligomer eliminating compound RD2 by Sarah Schemmert, Elena Schartmann, Dominik Honold, Christian Zafiu, Tamar Ziehm, Karl-Josef Langen, Nadim Joni Shah, Janine Kutzsche, Antje Willuweit, Dieter Willbold

Get full text

Safety and pharmacokinetics of the orally available antiprionic compound PRI‐002: A single and multiple ascending dose phase I study by Janine Kutzsche, Dagmar Jürgens, Antje Willuweit, Knut Adermann, Carola Fuchs, Stefanie Simons, Manfred Windisch, Michael Hümpel, Wolfgang Rossberg, Michael Wolzt, Dieter Willbold

Get full text

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity. by Stephan Rudolph, Antonia Nicole Klein, Markus Tusche, Christine Schlosser, Anne Elfgen, Oleksandr Brener, Charlotte Teunissen, Lothar Gremer, Susanne Aileen Funke, Janine Kutzsche, Dieter Willbold

Get full text

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination. by Antonia Nicole Klein, Tamar Ziehm, Markus Tusche, Johan Buitenhuis, Dirk Bartnik, Annett Boeddrich, Thomas Wiglenda, Erich Wanker, Susanne Aileen Funke, Oleksandr Brener, Lothar Gremer, Janine Kutzsche, Dieter Willbold

Get full text

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease. by Nan Jiang, Leonie H E Leithold, Julia Post, Tamar Ziehm, Jörg Mauler, Lothar Gremer, Markus Cremer, Elena Schartmann, N Jon Shah, Janine Kutzsche, Karl-Josef Langen, Jörg Breitkreutz, Dieter Willbold, Antje Willuweit

Get full text

Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs – A model of sporadic Alzheimer’s disease by Janine Kutzsche, Sarah Schemmert, Tuyen Bujnicki, Christian Zafiu, Steffen Halbgebauer, Victoria Kraemer-Schulien, Marlene Pils, Lara Blömeke, Julia Post, Andreas Kulawik, Dagmar Jürgens, Wolfgang M. Rossberg, Michael Hümpel, Oliver Bannach, Markus Otto, Joseph A. Araujo, Antje Willuweit, Dieter Willbold

Get full text

Elevated Aβ aggregates in feces from Alzheimer’s disease patients: a proof-of-concept study by Marlene Pils, Alexandra Dybala, Anja Schaffrath, Fabian Rehn, Janine Kutzsche, Lara Blömeke, Markus Tusche, Pelin Özdüzenciler, Tuyen Bujnicki, Victoria Kraemer-Schulien, Hannes Gramespacher, Maximilian H.T. Schmieschek, Michael T. Barbe, Oezguer A. Onur, Gereon R. Fink, Gültekin Tamgüney, Oliver Bannach, Dieter Willbold

Get full text

Blood-based quantification of Aβ oligomers indicates impaired clearance from brain in ApoE ε4 positive subjects by Lara Blömeke, Fabian Rehn, Marlene Pils, Victoria Kraemer-Schulien, Anneliese Cousin, Janine Kutzsche, Tuyen Bujnicki, Silka D. Freiesleben, Luisa-Sophie Schneider, Lukas Preis, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Sandra Roeske, Alfredo Ramirez, Matthias Schmid, Frank Jessen, Oliver Bannach, Oliver Peters, Dieter Willbold

Get full text

Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology by Lara Blömeke, Fabian Rehn, Victoria Kraemer‐Schulien, Janine Kutzsche, Marlene Pils, Tuyen Bujnicki, Piotr Lewczuk, Johannes Kornhuber, Silka D. Freiesleben, Luisa‐Sophie Schneider, Lukas Preis, Josef Priller, Eike J. Spruth, Slawek Altenstein, Andrea Lohse, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris‐Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Carolin Sanzenbacher, Annika Spottke, Nina Roy‐Kluth, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Steffen Wolfsgruber, Luca Kleineidam, Melina Stark, Matthias Schmid, Frank Jessen, Oliver Bannach, Dieter Willbold, Oliver Peters

Get full text