Editorial: Insights in human and medical genomics: 2022 by Jared C. Roach, Maxim B. Freidin

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Accurate and robust prediction of genetic relationship from whole-genome sequences. by Hong Li, Gustavo Glusman, Chad Huff, Juan Caballero, Jared C Roach

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Dense data enables 21st century clinical trials by Jared C. Roach, John F. Hodes, Cory C. Funk, William R Shankle, David A. Merrill, Leroy Hood, Jennifer Bramen

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A third approach to gene prediction suggests thousands of additional human transcribed regions. by Gustavo Glusman, Shizhen Qin, M Raafat El-Gewely, Andrew F Siegel, Jared C Roach, Leroy Hood, Arian F A Smit

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High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography. by Ruth Hershberg, Mikhail Lipatov, Peter M Small, Hadar Sheffer, Stefan Niemann, Susanne Homolka, Jared C Roach, Kristin Kremer, Dmitri A Petrov, Marcus W Feldman, Sebastien Gagneux

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Whole-genome sequencing of the world's oldest people. by Hinco J Gierman, Kristen Fortney, Jared C Roach, Natalie S Coles, Hong Li, Gustavo Glusman, Glenn J Markov, Justin D Smith, Leroy Hood, L Stephen Coles, Stuart K Kim

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Relationship estimation from whole-genome sequence data. by Hong Li, Gustavo Glusman, Hao Hu, Shankaracharya, Juan Caballero, Robert Hubley, David Witherspoon, Stephen L Guthery, Denise E Mauldin, Lynn B Jorde, Leroy Hood, Jared C Roach, Chad D Huff

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RTX-KG2: a system for building a semantically standardized knowledge graph for translational biomedicine by E. C. Wood, Amy K. Glen, Lindsey G. Kvarfordt, Finn Womack, Liliana Acevedo, Timothy S. Yoon, Chunyu Ma, Veronica Flores, Meghamala Sinha, Yodsawalai Chodpathumwan, Arash Termehchy, Jared C. Roach, Luis Mendoza, Andrew S. Hoffman, Eric W. Deutsch, David Koslicki, Stephen A. Ramsey

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The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design by Jared C. Roach, Junko Hara, Deborah Fridman, Jennifer C. Lovejoy, Kathleen Jade, Laura Heim, Rachel Romansik, Adrienne Swietlikowski, Sheree Phillips, Molly K. Rapozo, Maria A. Shay, Dan Fischer, Cory Funk, Lauren Dill, Michael Brant‐Zawadzki, Leroy Hood, William R. Shankle

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Correction: Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics. by Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich

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Correction: Uncovering a Macrophage Transcriptional Program by Integrating Evidence from Motif Scanning and Expression Dynamics. by Stephen A. Ramsey, Sandy L. Klemm, Daniel E. Zak, Kathleen A. Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S. Gold, Carrie D. Johnson, Vladimir Litvak, Garnet Navarro, Jared C. Roach, Carrie M. Rosenberger, Alistair G. Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich

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A systems‐biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease by Sarah C. McEwen, David A. Merrill, Jennifer Bramen, Verna Porter, Stella Panos, Scott Kaiser, John Hodes, Aarthi Ganapathi, Lesley Bell, Tess Bookheimer, Ryan Glatt, Molly Rapozo, Mary Kay Ross, Nathan D. Price, Daniel Kelly, Cory C. Funk, Leroy Hood, Jared C. Roach

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Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. by Stephen A Ramsey, Sandy L Klemm, Daniel E Zak, Kathleen A Kennedy, Vesteinn Thorsson, Bin Li, Mark Gilchrist, Elizabeth S Gold, Carrie D Johnson, Vladimir Litvak, Garnet Navarro, Jared C Roach, Carrie M Rosenberger, Alistair G Rust, Natalya Yudkovsky, Alan Aderem, Ilya Shmulevich

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Population-specific genetic modification of Huntington's disease in Venezuela. by Michael J Chao, Kyung-Hee Kim, Jun Wan Shin, Diane Lucente, Vanessa C Wheeler, Hong Li, Jared C Roach, Leroy Hood, Nancy S Wexler, Laura B Jardim, Peter Holmans, Lesley Jones, Michael Orth, Seung Kwak, Marcy E MacDonald, James F Gusella, Jong-Min Lee

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Identification of copy number variants in whole-genome data using Reference Coverage Profiles by Gustavo eGlusman, Alissa eSeverson, Varsha eDhankani, Max eRobinson, Terry eFarrah, Denise E. Mauldin, Anna B. Stittrich, Seth A. Ament, Jared C. Roach, Mary E. Brunkow, Dale L. Bodian, Joseph G. Vockley, Ilya eShmulevich, John E. Niederhuber, Leroy eHood

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Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers by Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G. Garcia, Michael R. Hoopmann, Mukul K. Midha, David H. Baxter, Michal Maes, Seamus R. Morrone, Kelly M. Crebs, Charu Kapil, Ulrike Kusebauch, Jack Wiedrick, Jodi Lapidus, Lance Pflieger, Christopher Lausted, Jared C. Roach, Gwênlyn Glusman, Steven R. Cummings, Nicholas J. Schork, Nathan D. Price, Leroy Hood, Richard A. Miller, Robert L. Moritz, Noa Rappaport

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Author Correction: Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers by Kengo Watanabe, Tomasz Wilmanski, Priyanka Baloni, Max Robinson, Gonzalo G. Garcia, Michael R. Hoopmann, Mukul K. Midha, David H. Baxter, Michal Maes, Seamus R. Morrone, Kelly M. Crebs, Charu Kapil, Ulrike Kusebauch, Jack Wiedrick, Jodi Lapidus, Lance Pflieger, Christopher Lausted, Jared C. Roach, Gwênlyn Glusman, Steven R. Cummings, Nicholas J. Schork, Nathan D. Price, Leroy Hood, Richard A. Miller, Robert L. Moritz, Noa Rappaport

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Reinfection with SARS-CoV-2 and Waning Humoral Immunity: A Case Report by Jason D. Goldman, Kai Wang, Katharina Röltgen, Sandra C. A. Nielsen, Jared C. Roach, Samia N. Naccache, Fan Yang, Oliver F. Wirz, Kathryn E. Yost, Ji-Yeun Lee, Kelly Chun, Terri Wrin, Christos J. Petropoulos, Inyoul Lee, Shannon Fallen, Paula M. Manner, Julie A. Wallick, Heather A. Algren, Kim M. Murray, Jennifer Hadlock, Daniel Chen, Chengzhen L. Dai, Dan Yuan, Yapeng Su, Joshua Jeharajah, William R. Berrington, George P. Pappas, Sonam T. Nyatsatsang, Alexander L. Greninger, Ansuman T. Satpathy, John S. Pauk, Scott D. Boyd, James R. Heath

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Correction: Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry. by Louis Viollet, Gustavo Glusman, Kelley J Murphy, Tara M Newcomb, Sandra P Reyna, Matthew Sweney, Benjamin Nelson, Frederick Andermann, Eva Andermann, Gyula Acsadi, Richard L Barbano, Candida Brown, Mary E Brunkow, Harry T Chugani, Sarah R Cheyette, Abigail Collins, Suzanne D DeBrosse, David Galas, Jennifer Friedman, Lee Hood, Chad Huff, Lynn B Jorde, Mary D King, Bernie LaSalle, Richard J Leventer, Aga J Lewelt, Mylynda B Massart, Mario R Mérida, Louis J Ptáček, Jared C Roach, Robert S Rust, Francis Renault, Terry D Sanger, Marcio A Sotero de Menezes, Rachel Tennyson, Peter Uldall, Yue Zhang, Mary Zupanc, Winnie Xin, Kenneth Silver, Kathryn J Swoboda

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Alternating Hemiplegia of Childhood: Retrospective Genetic Study and Genotype-Phenotype Correlations in 187 Subjects from the US AHCF Registry. by Louis Viollet, Gustavo Glusman, Kelley J Murphy, Tara M Newcomb, Sandra P Reyna, Matthew Sweney, Benjamin Nelson, Frederick Andermann, Eva Andermann, Gyula Acsadi, Richard L Barbano, Candida Brown, Mary E Brunkow, Harry T Chugani, Sarah R Cheyette, Abigail Collins, Suzanne D DeBrosse, David Galas, Jennifer Friedman, Lee Hood, Chad Huff, Lynn B Jorde, Mary D King, Bernie LaSalle, Richard J Leventer, Aga J Lewelt, Mylynda B Massart, Mario R Mérida, Louis J Ptáček, Jared C Roach, Robert S Rust, Francis Renault, Terry D Sanger, Marcio A Sotero de Menezes, Rachel Tennyson, Peter Uldall, Yue Zhang, Mary Zupanc, Winnie Xin, Kenneth Silver, Kathryn J Swoboda

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