Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function by Eric Escobar-Cabrera, Paula Lario, Jason Baardsnes, Joseph Schrag, Yves Durocher, Surjit Dixit

Get full text

Structure of CbpA J-domain bound to the regulatory protein Cbpm explains its specificity and suggests evolutionary link between Cbpm and transcriptional regulators. by Naghmeh S Sarraf, Rong Shi, Laura McDonald, Jason Baardsnes, Linhua Zhang, Miroslaw Cygler, Irena Ekiel

Get full text

A Novel Affinity Tag, ABTAG, and Its Application to the Affinity Screening of Single-Domain Antibodies Selected by Phage Display by Greg Hussack, Toya Nath Baral, Jason Baardsnes, Henk van Faassen, Shalini Raphael, Kevin A. Henry, Jianbing Zhang, C. Roger MacKenzie

Get full text

Exploring rigid-backbone protein docking in biologics discovery: a test using the DARPin scaffold by Francis Gaudreault, Jason Baardsnes, Yuliya Martynova, Aurore Dachon, Hervé Hogues, Christopher R. Corbeil, Enrico O. Purisima, Mélanie Arbour, Traian Sulea, Traian Sulea

Get full text

Structure-based dual affinity optimization of a SARS-CoV-1/2 cross-reactive single-domain antibody. by Traian Sulea, Jason Baardsnes, Matthew Stuible, Nazanin Rohani, Anh Tran, Marie Parat, Yuneivy Cepero Donates, Mélanie Duchesne, Pierre Plante, Guneet Kour, Yves Durocher

Get full text

Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences by Christopher R. Corbeil, Mahder Seifu Manenda, Traian Sulea, Jason Baardsnes, Marie-Ève Picard, Hervé Hogues, Francis Gaudreault, Christophe Deprez, Rong Shi, Enrico O. Purisima

Get full text

Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates. by John C Zwaagstra, Traian Sulea, Jason Baardsnes, Stevo Radinovic, Yuneivy Cepero-Donates, Alma Robert, Maureen D O'Connor-McCourt, Ilia A Tikhomirov, Maria Luz Jaramillo

Get full text

Generation of monoclonal pan-hemagglutinin antibodies for the quantification of multiple strains of influenza. by Aziza P Manceur, Wei Zou, Anne Marcil, Eric Paquet, Christine Gadoury, Bozena Jaentschke, Xuguang Li, Emma Petiot, Yves Durocher, Jason Baardsnes, Manuel Rosa-Calatrava, Sven Ansorge, Amine A Kamen

Get full text

Assisted Design of Antibody and Protein Therapeutics (ADAPT). by Victor Vivcharuk, Jason Baardsnes, Christophe Deprez, Traian Sulea, Maria Jaramillo, Christopher R Corbeil, Alaka Mullick, Joanne Magoon, Anne Marcil, Yves Durocher, Maureen D O'Connor-McCourt, Enrico O Purisima

Get full text

AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design by Mario Sanches, Igor D’Angelo, Maria Jaramillo, Jason Baardsnes, John Zwaagstra, Joe Schrag, Ian Schoenhofen, Mauro Acchione, Sam Lawn, Grant Wickman, Nina Weisser, David K. Y. Poon, Gordon Ng, Surjit Dixit

Get full text

Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment by Traian Sulea, Nazanin Rohani, Jason Baardsnes, Christopher R. Corbeil, Christophe Deprez, Yuneivy Cepero-Donates, Alma Robert, Joseph D. Schrag, Marie Parat, Mélanie Duchesne, Maria L. Jaramillo, Enrico O. Purisima, John C. Zwaagstra

Get full text

Binding symmetry and surface flexibility mediate antibody self-association by Joseph D. Schrag, Marie-Ève Picard, Francis Gaudreault, Louis-Patrick Gagnon, Jason Baardsnes, Mahder S. Manenda, Joey Sheff, Christophe Deprez, Cassio Baptista, Hervé Hogues, John F. Kelly, Enrico O. Purisima, Rong Shi, Traian Sulea

Get full text

Tuning the immune response: sulfated archaeal glycolipid archaeosomes as an effective vaccine adjuvant for induction of humoral and cell-mediated immunity towards the SARS-CoV-2 Om... by Tyler M. Renner, Bassel Akache, Matthew Stuible, Nazanin Rohani, Yuneivy Cepero-Donates, Lise Deschatelets, Renu Dudani, Blair A. Harrison, Jason Baardsnes, Izel Koyuturk, Jennifer J. Hill, Usha D. Hemraz, Sophie Régnier, Anne E. G. Lenferink, Yves Durocher, Michael J. McCluskie

Get full text

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX by Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Anne E.G. Lenferink

Get full text

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX by Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard, Shoukat Dedhar

Get full text

An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity by Nina E. Weisser, Mario Sanches, Eric Escobar-Cabrera, Jason O’Toole, Elizabeth Whalen, Peter W. Y. Chan, Grant Wickman, Libin Abraham, Kate Choi, Bryant Harbourne, Antonios Samiotakis, Andrea Hernández Rojas, Gesa Volkers, Jodi Wong, Claire E. Atkinson, Jason Baardsnes, Liam J. Worrall, Duncan Browman, Emma E. Smith, Priya Baichoo, Chi Wing Cheng, Joy Guedia, Sohyeong Kang, Abhishek Mukhopadhyay, Lisa Newhook, Anders Ohrn, Prajwal Raghunatha, Matteo Zago-Schmitt, Joseph D. Schrag, Joel Smith, Patricia Zwierzchowski, Joshua M. Scurll, Vincent Fung, Sonia Black, Natalie C. J. Strynadka, Michael R. Gold, Leonard G. Presta, Gordon Ng, Surjit Dixit

Get full text