Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage. por David Sacks, Jinal N Bhiman, Kevin Wiehe, Jason Gorman, Peter D Kwong, Lynn Morris, Penny L Moore

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Anti-idiotype isolation of a broad and potent influenza A virus-neutralizing human antibody por Adam S. Olia, Madhu Prabhakaran, Darcy R. Harris, Crystal Sao-Fong Cheung, Rebecca A. Gillespie, Jason Gorman, Jason Gorman, Abigayle Hoover, Nicholas C. Morano, Nicholas C. Morano, Amine Ourahmane, Abhinaya Srikanth, Shuishu Wang, Weiwei Wu, Tongqing Zhou, Sarah F. Andrews, Masaru Kanekiyo, Lawrence Shapiro, Lawrence Shapiro, Lawrence Shapiro, Adrian B. McDermott, Peter D. Kwong, Peter D. Kwong, Peter D. Kwong

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N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function. por Marie Pancera, Yongping Yang, Mark K Louder, Jason Gorman, Gabriel Lu, Jason S McLellan, Jonathan Stuckey, Jiang Zhu, Dennis R Burton, Wayne C Koff, John R Mascola, Peter D Kwong

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HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations por Xiaochu Ma, Maolin Lu, Jason Gorman, Daniel S Terry, Xinyu Hong, Zhou Zhou, Hong Zhao, Roger B Altman, James Arthos, Scott C Blanchard, Peter D Kwong, James B Munro, Walther Mothes

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Transplanting supersites of HIV-1 vulnerability. por Tongqing Zhou, Jiang Zhu, Yongping Yang, Jason Gorman, Gilad Ofek, Sanjay Srivatsan, Aliaksandr Druz, Christopher R Lees, Gabriel Lu, Cinque Soto, Jonathan Stuckey, Dennis R Burton, Wayne C Koff, Mark Connors, Peter D Kwong

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Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes por Raffaello Verardi, Lisa C. Lindesmith, Yaroslav Tsybovsky, Jason Gorman, Gwo-Yu Chuang, Caitlin E. Edwards, Paul D. Brewer-Jensen, Michael L. Mallory, Li Ou, Arne Schön, Wei Shi, Ena S. Tully, George Georgiou, Ralph S. Baric, Peter D. Kwong

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Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces por Myungjin Lee, Anita Changela, Jason Gorman, Reda Rawi, Tatsiana Bylund, Cara W. Chao, Bob C. Lin, Mark K. Louder, Adam S. Olia, Baoshan Zhang, Nicole A. Doria-Rose, Susan Zolla-Pazner, Lawrence Shapiro, Gwo-Yu Chuang, Peter D. Kwong

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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs por Kai Xu, Yiran Wang, Chen-Hsiang Shen, Yiwei Chen, Baoshan Zhang, Kevin Liu, Yaroslav Tsybovsky, Shuishu Wang, S. Katie Farney, Jason Gorman, Tyler Stephens, Raffaello Verardi, Yongping Yang, Tongqing Zhou, Gwo-Yu Chuang, Antonio Lanzavecchia, Luca Piccoli, Peter D. Kwong

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Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design por Graham T. Holt, Jason Gorman, Siyu Wang, Anna U. Lowegard, Baoshan Zhang, Tracy Liu, Bob C. Lin, Mark K. Louder, Marcel S. Frenkel, Krisha McKee, Sijy O’Dell, Reda Rawi, Chen-Hsiang Shen, Nicole A. Doria-Rose, Peter D. Kwong, Bruce R. Donald

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Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. por Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer

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Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation por Erik L. Johnson, Nicole A. Doria-Rose, Jason Gorman, Jinal N. Bhiman, Chaim A. Schramm, Ashley Q. Vu, William H. Law, Baoshan Zhang, Valerie Bekker, Salim S. Abdool Karim, Gregory C. Ippolito, Lynn Morris, Penny L. Moore, Peter D. Kwong, John R. Mascola, George Georgiou

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Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability. por Rosemarie D Mason, Hugh C Welles, Cameron Adams, Bimal K Chakrabarti, Jason Gorman, Tongqing Zhou, Richard Nguyen, Sijy O'Dell, Sabrina Lusvarghi, Carole A Bewley, Hui Li, George M Shaw, Zizhang Sheng, Lawrence Shapiro, Richard Wyatt, Peter D Kwong, John R Mascola, Mario Roederer

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A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention por Young D. Kwon, Mangaiarkarasi Asokan, Jason Gorman, Baoshan Zhang, Qingbo Liu, Mark K. Louder, Bob C. Lin, Krisha McKee, Amarendra Pegu, Raffaello Verardi, Eun Sung Yang, VRC Production Program, Kevin Carlton, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola, Peter D. Kwong

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Structural development of the HIV-1 apex-directed PGT145-PGDM1400 antibody lineage por Rosemarie D. Mason, Baoshan Zhang, Nicholas C. Morano, Chen-Hsiang Shen, Krisha McKee, Ashley Heimann, Renguang Du, Alexandra F. Nazzari, Shelby Hodges, Tapan Kanai, Bob C. Lin, Mark K. Louder, Nicole A. Doria-Rose, Tongqing Zhou, Lawrence Shapiro, Mario Roederer, Peter D. Kwong, Jason Gorman

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Tyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency por Cindy X. Cai, Nicole A. Doria-Rose, Nicole A. Schneck, Vera B. Ivleva, Brad Tippett, William R. Shadrick, Sarah O’Connell, Jonathan W. Cooper, Zachary Schneiderman, Baoshan Zhang, Daniel B. Gowetski, Daniel Blackstock, Jacob Demirji, Bob C. Lin, Jason Gorman, Tracy Liu, Yile Li, Adrian B. McDermott, Peter D. Kwong, Kevin Carlton, Jason G. Gall, Q. Paula Lei

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Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape. por Constantinos Kurt Wibmer, Jason Gorman, Gabriel Ozorowski, Jinal N Bhiman, Daniel J Sheward, Debra H Elliott, Julie Rouelle, Ashley Smira, M Gordon Joyce, Nonkululeko Ndabambi, Aliaksandr Druz, Mangai Asokan, Mangai Asokan, Dennis R Burton, Mark Connors, Salim S Abdool Karim, John R Mascola, James E Robinson, Andrew B Ward, Carolyn Williamson, Peter D Kwong, Lynn Morris, Penny L Moore

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Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes. por Sean P O'Brien, Adrienne E Swanstrom, Amarendra Pegu, Sung-Youl Ko, Taina T Immonen, Gregory Q Del Prete, Christine M Fennessey, Jason Gorman, Kathryn E Foulds, Stephen D Schmidt, Nicole Doria-Rose, Carolyn Williamson, Theodora Hatziioannou, Paul D Bieniasz, Hui Li, George M Shaw, John R Mascola, Richard A Koup, Peter D Kwong, Jeffrey D Lifson, Mario Roederer, Brandon F Keele

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Broad coverage of neutralization-resistant SIV strains by second-generation SIV-specific antibodies targeting the region involved in binding CD4. por Hugh C Welles, Hannah A D King, Leonard Nettey, Nicole Cavett, Jason Gorman, Tongqing Zhou, Yaroslav Tsybovsky, Renguang Du, Kaimei Song, Richard Nguyen, David Ambrozak, Amy Ransier, Chaim A Schramm, Nicole A Doria-Rose, Adrienne E Swanstrom, James A Hoxie, Celia LaBranche, David C Montefiori, Daniel C Douek, Peter D Kwong, John R Mascola, Mario Roederer, Rosemarie D Mason

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Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency por Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola, Peter D. Kwong

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Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2 por Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu, Mark K. Louder, Nicole A. Doria‐Rose, Kevin Wiehe, Alexandra F. Nazzari, Adam S. Olia, Jason Gorman, Reda Rawi, Wenmin Wu, Clayton Smith, Htet Khant, Natalia de Val, Bin Yu, Junhong Luo, Haitao Niu, Yaroslav Tsybovsky, Huaxin Liao, Thomas B. Kepler, Peter D. Kwong, John R. Mascola, Chuan Qin, Tongqing Zhou, Xianghui Yu, Feng Gao

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