Novel insights into the epigenetics of diffuse glioma by Carla Danussi, Jason T. Huse

Get full text

Coexisting FGFR3 p.K650T mutation in two FGFR3-TACC3 fusion glioma cases by Leomar Y. Ballester, Soheil Zorofchian Moghadamtousi, Norman E. Leeds, Jason T. Huse, Gregory N. Fuller

Get full text

miR-34a repression in proneural malignant gliomas upregulates expression of its target PDGFRA and promotes tumorigenesis. by Joachim Silber, Anders Jacobsen, Tatsuya Ozawa, Girish Harinath, Alicia Pedraza, Chris Sander, Eric C Holland, Jason T Huse

Get full text

Histological transformation to gliosarcoma with combined BRAF/MEK inhibition in BRAF V600E mutated glioblastoma by Blessie Elizabeth Nelson, Neha K. Reddy, Jason T. Huse, Behrang Amini, Mirella Nardo, Mohamed Gouda, Shiao-Pei Weathers, Vivek Subbiah

Get full text

EGFR and PDGFRA co-expression and heterodimerization in glioblastoma tumor sphere lines by Debyani Chakravarty, Alicia M. Pedraza, Jesse Cotari, Angela H. Liu, Diana Punko, Aushim Kokroo, Jason T. Huse, Gregoire Altan-Bonnet, Cameron W. Brennan

Get full text

Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression. by Elena I Fomchenko, Joseph D Dougherty, Karim Y Helmy, Amanda M Katz, Alexander Pietras, Cameron Brennan, Jason T Huse, Ana Milosevic, Eric C Holland

Get full text

Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling by Barbara Oldrini, Álvaro Curiel-García, Carolina Marques, Veronica Matia, Özge Uluçkan, Osvaldo Graña-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito

Get full text

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma by Yuxiang Wang, Jie Yang, Aaron T. Wild, Wei H. Wu, Rachna Shah, Carla Danussi, Gregory J. Riggins, Kasthuri Kannan, Erik P. Sulman, Timothy A. Chan, Jason T. Huse

Get full text

High throughput single cell long-read sequencing analyses of same-cell genotypes and phenotypes in human tumors by Cheng-Kai Shiau, Lina Lu, Rachel Kieser, Kazutaka Fukumura, Timothy Pan, Hsiao-Yun Lin, Jie Yang, Eric L. Tong, GaHyun Lee, Yuanqing Yan, Jason T. Huse, Ruli Gao

Get full text

DNA methylation-based epigenetic signatures predict somatic genomic alterations in gliomas by Jie Yang, Qianghu Wang, Ze-Yan Zhang, Lihong Long, Ravesanker Ezhilarasan, Jerome M. Karp, Aristotelis Tsirigos, Matija Snuderl, Benedikt Wiestler, Wolfgang Wick, Yinsen Miao, Jason T. Huse, Erik P. Sulman

Get full text

A Cell Engineering Strategy to Enhance the Safety of Stem Cell Therapies by Elisa Oricchio, Eirini P. Papapetrou, Fabien Lafaille, Yosif M. Ganat, Sonja Kriks, Ana Ortega-Molina, Willie H. Mark, Julie Teruya-Feldstein, Jason T. Huse, Victor Reuter, Michel Sadelain, Lorenz Studer, Hans-Guido Wendel

Get full text

Involvement of miRNAs in the differentiation of human glioblastoma multiforme stem-like cells. by Beatriz Aldaz, Ainara Sagardoy, Lorena Nogueira, Elizabeth Guruceaga, Lara Grande, Jason T Huse, Maria A Aznar, Ricardo Díez-Valle, Sonia Tejada-Solís, Marta M Alonso, Jose L Fernandez-Luna, Jose A Martinez-Climent, Raquel Malumbres

Get full text

The genomic alterations in glioblastoma influence the levels of CSF metabolites by Daniel H. Wang, Yoko Fujita, Antonio Dono, Ana G. Rodriguez Armendariz, Mauli Shah, Nagireddy Putluri, Pavel S. Pichardo-Rojas, Chirag B. Patel, Jay-Jiguang Zhu, Jason T. Huse, Brittany C. Parker Kerrigan, Frederick F. Lang, Yoshua Esquenazi, Leomar Y. Ballester

Get full text

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling by Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse

Get full text

Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration by Martina Ott, Karl-Heinz Tomaszowski, Anantha Marisetty, Ling-Yuan Kong, Jun Wei, Maya Duna, Katia Blumberg, Xiaorong Ji, Carmen Jacobs, Gregory N. Fuller, Lauren A. Langford, Jason T. Huse, James P. Long, Jian Hu, Shulin Li, Jeffrey S. Weinberg, Sujit S. Prabhu, Raymond Sawaya, Sherise Ferguson, Ganesh Rao, Frederick F. Lang, Michael A. Curran, Amy B. Heimberger

Get full text

Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine by Yasaman Barekatain, Jeffrey J. Ackroyd, Victoria C. Yan, Sunada Khadka, Lin Wang, Ko-Chien Chen, Anton H. Poral, Theresa Tran, Dimitra K. Georgiou, Kenisha Arthur, Yu-Hsi Lin, Nikunj Satani, Elliot S. Ballato, Eliot I. Behr, Ana C. deCarvalho, Roel G. W. Verhaak, John de Groot, Jason T. Huse, John M. Asara, Raghu Kalluri, Florian L. Muller

Get full text

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas by Seethalakshmi Hariharan, Benjamin T. Whitfield, Christopher J. Pirozzi, Matthew S. Waitkus, Michael C. Brown, Michelle L. Bowie, David M. Irvin, Kristen Roso, Rebecca Fuller, Janell Hostettler, Sharvari Dharmaiah, Emiley A. Gibson, Aaron Briley, Avani Mangoli, Casey Fraley, Mariah Shobande, Kevin Stevenson, Gao Zhang, Prit Benny Malgulwar, Hannah Roberts, Martin Roskoski, Ivan Spasojevic, Stephen T. Keir, Yiping He, Maria G. Castro, Jason T. Huse, David M. Ashley

Get full text

Central nervous system immune interactome is a function of cancer lineage, tumor microenvironment, and STAT3 expression by Hinda Najem, Martina Ott, Cynthia Kassab, Arvind Rao, Ganesh Rao, Anantha Marisetty, Adam M. Sonabend, Craig Horbinski, Roel Verhaak, Anand Shankar, Santhoshi N. Krishnan, Frederick S. Varn, Víctor A. Arrieta, Pravesh Gupta, Sherise D. Ferguson, Jason T. Huse, Gregory N. Fuller, James P. Long, Daniel E. Winkowski, Ben A. Freiberg, Charles David James, Leonidas C. Platanias, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger

Get full text

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes by Konrad Gabrusiewicz, Xu Li, Jun Wei, Yuuri Hashimoto, Anantha L. Marisetty, Martina Ott, Fei Wang, David Hawke, John Yu, Luke M. Healy, Anwar Hossain, Johnny C. Akers, Sourindra N. Maiti, Shinji Yamashita, Yuzaburo Shimizu, Kenneth Dunner, M. Anna Zal, Jared K. Burks, Joy Gumin, Felix Nwajei, Aras Rezavanian, Shouhao Zhou, Ganesh Rao, Raymond Sawaya, Gregory N. Fuller, Jason T. Huse, Jack P. Antel, Shulin Li, Laurence Cooper, Erik P. Sulman, Clark Chen, Changiz Geula, Raghu Kalluri, Tomasz Zal, Amy B. Heimberger

Get full text

Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity by Won-Chul Lee, Alexandre Reuben, Xin Hu, Nicholas McGranahan, Runzhe Chen, Ali Jalali, Marcelo V. Negrao, Shawna M. Hubert, Chad Tang, Chia-Chin Wu, Anthony San Lucas, Whijae Roh, Kenichi Suda, Jihye Kim, Aik-Choon Tan, David H. Peng, Wei Lu, Ximing Tang, Chi-Wan Chow, Junya Fujimoto, Carmen Behrens, Neda Kalhor, Kazutaka Fukumura, Marcus Coyle, Rebecca Thornton, Curtis Gumbs, Jun Li, Chang-Jiun Wu, Latasha Little, Emily Roarty, Xingzhi Song, J. Jack Lee, Erik P. Sulman, Ganesh Rao, Stephen Swisher, Lixia Diao, Jing Wang, John V. Heymach, Jason T. Huse, Paul Scheet, Ignacio I. Wistuba, Don L. Gibbons, P. Andrew Futreal, Jianhua Zhang, Daniel Gomez, Jianjun Zhang

Get full text