Editorial: Tumor Heterogeneity by Stefano La Rosa, Laura Rubbia-Brandt, Jean-Yves Scoazec, Jean-Yves Scoazec, Achim Weber, Achim Weber

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A practical proposal on treatment sequencing of metastatic well-differentiated neuroendocrine tumours by Marine Perrier, Jean-Yves Scoazec, Thomas Walter

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Focal nodular hyperplasia of the liver with pseudo-angiomatous appearance of the central area: MRI findings and pathophysiological insights by Ludivine Glas, Jean Yves Scoazec, Mustapha Adham, Frank Pilleul

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TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth by Maria-Vittoria Sepporta, Viviane Praz, Katia Balmas Bourloud, Jean-Marc Joseph, Nicolas Jauquier, Nicolò Riggi, Katya Nardou-Auderset, Audrey Petit, Jean-Yves Scoazec, Hervé Sartelet, Raffaele Renella, Annick Mühlethaler-Mottet

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Molecular profiling of biliary tract cancers reveals distinct genomic landscapes between circulating and tissue tumor DNA by Clémence Astier, Carine Ngo, Léo Colmet-Daage, Virginie Marty, Olivia Bawa, Claudio Nicotra, Maud Ngo-Camus, Antoine Italiano, Christophe Massard, Jean-Yves Scoazec, Cristina Smolenschi, Michel Ducreux, Antoine Hollebecque, Sophie Postel-Vinay

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Higher risk profile among patients with TET2-mutated giant cell arteritis: a cluster analysis by Arsène Mekinian, Nabil Belfeki, Olivier Fain, Jean-Yves Scoazec, Olivier Hermine, Julien Rossignol, Nouha Ghriss, Azeddine Dellal, Olivier Espitia, Alexis F Guedon, Christophe Marzac, Asmaa Ouafdi, Marc Scheen, Fadi Haidar, Eric Solary

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B cells and the coordination of immune checkpoint inhibitor response in patients with solid tumors by Jean-Yves Scoazec, Francois-Xavier Danlos, Laurence Albiges, Bernard Escudier, Ronan Flippot, Lydie Cassard, Nathalie Chaput, Natacha Naoun, Marie Naigeon, Jean-Mehdi Jouniaux, Lisa Boselli, Lucia Carril-Ajuria, Marcus Teixeira, Macarena Rey-Cardenas, Larissa Rainho

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Prognostic value of tumor immune biomarkers in biopsies from patients with refractory solid cancers by Tiphaine Lambert, Cedric Pobel, Léo Colmet-Daage, Amélie Bigorgne, Brice RaubyY, Nicolas Sanchez-Escobar Aladro, Lucile Ter-MinassianN, Marie Kerisit, Aurélien Marabelle, Benjamin Besse, Antoine Hollebecque, Stéphane Champiat, Christophe Massard, Daphné Morel, Loic Velringue, Jean-Yves Scoazec

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Targeting genome integrity dysfunctions impedes metastatic potency in non–small cell lung cancer circulating tumor cell–derived explants by Tala Tayoun, Vincent Faugeroux, Marianne Oulhen, Olivier Déas, Judith Michels, Laura Brulle-Soumare, Stefano Cairo, Jean-Yves Scoazec, Virginie Marty, Agathe Aberlenc, David Planchard, Jordi Remon, Santiago Ponce, Benjamin Besse, Patricia L. Kannouche, Jean-Gabriel Judde, Patrycja Pawlikowska, Françoise Farace

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Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers by Jean-Yves Scoazec, Antoine Hollebecque, Aurélien Marabelle, Alexandra Leary, Lydie Cassard, Nathalie Chaput, Cristina Smolenschi, Perrine Vuagnat, Jean-Mehdi Jouniaux, Laetitia Nebot-Bral, Andrey A Yurchenko, Louise de Forceville, Mathieu Danjou, Reginaldo C A Rosa, Caroline Pouvelle, Said Aoufouchi, Emeline Colomba, Sergey Nikolaev, Patricia Kannouche

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Correction: Inactivation of TIF1γ Cooperates with Kras to Induce Cystic Tumors of the Pancreas. by David F. Vincent, Kai-Ping Yan, Isabelle Treilleux, Fabien Gay, Vanessa Arfi, Bastien Kaniewski, Julien C. Marie, Florian Lepinasse, Sylvie Martel, Sophie Goddard-Leon, Juan L. Iovanna, Pierre Dubus, Stéphane Garcia, Alain Puisieux, Ruth Rimokh, Nabeel Bardeesy, Jean-Yves Scoazec, Régine Losson, Laurent Bartholin

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CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17 by Stéphanie Corgnac, Ines Malenica, Laura Mezquita, Edouard Auclin, Elodie Voilin, Jamila Kacher, Heloise Halse, Laetitia Grynszpan, Nicolas Signolle, Thibault Dayris, Marine Leclerc, Nathalie Droin, Vincent de Montpréville, Olaf Mercier, Pierre Validire, Jean-Yves Scoazec, Christophe Massard, Salem Chouaib, David Planchard, Julien Adam, Benjamin Besse, Fathia Mami-Chouaib

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Longitudinal characterization of primary osteosarcoma and derived subcutaneous and orthotopic relapsed patient-derived xenograft models by Maria Eugenia Marques da Costa, Maria Eugenia Marques da Costa, Robin Droit, Pierre Khneisser, Anne Gomez-Brouchet, Tiphaine Adam-de-Beaumais, Marie Nolla, Nicolas Signolles, Jacob Torrejon, Jacob Torrejon, Bérangère Lombard, Damarys Loew, Olivier Ayrault, Olivier Ayrault, Jean-Yves Scoazec, Birgit Geoerger, Birgit Geoerger, Gilles Vassal, Antonin Marchais, Antonin Marchais, Nathalie Gaspar, Nathalie Gaspar

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Phenotypic discordance between primary and metastatic breast cancer in the large-scale real-life multicenter French ESME cohort by Thomas Grinda, Natacha Joyon, Amélie Lusque, Sarah Lefèvre, Laurent Arnould, Frédérique Penault-Llorca, Gaëtan Macgrogan, Isabelle Treilleux, Anne Vincent-Salomon, Juliette Haudebourg, Aurélie Maran-Gonzalez, Emmanuelle Charafe-Jauffret, Coralie Courtinard, Camille Franchet, Véronique Verriele, Etienne Brain, Patrick Tas, Cécile Blanc-Fournier, Agnès Leroux, Delphine Loussouarn, Anca Berghian, Eva Brabencova, Jean Pierre Ghnassia, Jean-Yves Scoazec, Suzette Delaloge, Thomas Filleron, Magali Lacroix-Triki

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Comprehensive molecular portrait reveals genetic diversity and distinct molecular subtypes of small intestinal neuroendocrine tumors by Céline Patte, Roxane M. Pommier, Anthony Ferrari, Felicia Fei-Lei Chung, Maria Ouzounova, Pauline Moullé, Mathieu Richaud, Rita Khoueiry, Maëva Hervieu, Silvia Breusa, Marion Allio, Nicolas Rama, Laura Gérard, Valérie Hervieu, Gilles Poncet, Tanguy Fenouil, Vincent Cahais, Anne-Sophie Sertier, Anne Boland, Delphine Bacq-Daian, Benjamin Ducarouge, Julien C. Marie, Jean-François Deleuze, Alain Viari, Jean-Yves Scoazec, Colette Roche, Patrick Mehlen, Thomas Walter, Benjamin Gibert

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Author Correction: The genomic and transcriptomic landscape of metastastic urothelial cancer by Yohann Loriot, Maud Kamal, Laurene Syx, Remy Nicolle, Celia Dupain, Naoual Menssouri, Igor Duquesne, Pernelle Lavaud, Claudio Nicotra, Maud Ngocamus, Ludovic Lacroix, Lambros Tselikas, Gilles Crehange, Luc Friboulet, Zahra Castel-Ajgal, Yann Neuzillet, Edith Borcoman, Philippe Beuzeboc, Grégoire Marret, Tom Gutman, Jennifer Wong, Francois Radvanyi, Sylvain Dureau, Jean-Yves Scoazec, Nicolas Servant, Yves Allory, Benjamin Besse, Fabrice Andre, Christophe Le tourneau, Christophe Massard, Ivan Bieche

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The genomic and transcriptomic landscape of metastastic urothelial cancer by Yohann Loriot, Maud Kamal, Laurene Syx, Remy Nicolle, Celia Dupain, Naoual Menssouri, Igor Duquesne, Pernelle Lavaud, Claudio Nicotra, Maud Ngocamus, Ludovic Lacroix, Lambros Tselikas, Gilles Crehange, Luc Friboulet, Zahra Castel-Ajgal, Yann Neuzillet, Edith Borcoman, Philippe Beuzeboc, Grégoire Marret, Tom Gutman, Jennifer Wong, Francois Radvanyi, Sylvain Dureau, Jean-Yves Scoazec, Nicolas Servant, Yves Allory, Benjamin Besse, Fabrice Andre, Christophe Le tourneau, Christophe Massard, Ivan Bieche

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Divergent HLA variations and heterogeneous expression but recurrent HLA loss-of- heterozygosity and common HLA-B and TAP transcriptional silencing across advanced pediatric solid c... by Wan Ching Lim, Wan Ching Lim, Wan Ching Lim, Maria Eugenia Marques Da Costa, Karine Godefroy, Eric Jacquet, Loren Gragert, Windy Rondof, Windy Rondof, Antonin Marchais, Antonin Marchais, Naima Nhiri, Davide Dalfovo, Mathias Viard, Mathias Viard, Nizar Labaied, Asif M. Khan, Philippe Dessen, Alessandro Romanel, Claudia Pasqualini, Claudia Pasqualini, Gudrun Schleiermacher, Mary Carrington, Mary Carrington, Mary Carrington, Laurence Zitvogel, Jean-Yves Scoazec, Birgit Geoerger, Birgit Geoerger, Jerome Salmon

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Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development by Damien Vasseur, Ludovic Bigot, Kristi Beshiri, Juan Flórez-Arango, Francesco Facchinetti, Antoine Hollebecque, Lambros Tselikas, Mihaela Aldea, Felix Blanc-Durand, Anas Gazzah, David Planchard, Ludovic Lacroix, Noémie Pata-Merci, Catline Nobre, Alice Da Silva, Claudio Nicotra, Maud Ngo-Camus, Floriane Braye, Sergey I. Nikolaev, Stefan Michiels, Gérôme Jules-Clement, Ken André Olaussen, Fabrice André, Jean-Yves Scoazec, Fabrice Barlesi, Santiago Ponce, Jean-Charles Soria, Benjamin Besse, Yohann Loriot, Luc Friboulet

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Immune checkpoints are predominantly co-expressed by clonally expanded CD4+FoxP3+ intratumoral T-cells in primary human cancers by Delphine Bredel, Edi Tihic, Séverine Mouraud, François-Xavier Danlos, Sandrine Susini, Marine Aglave, Alexia Alfaro, Chifaou Mohamed-Djalim, Mathieu Rouanne, Héloise Halse, Amélie Bigorgne, Lambros Tselikas, Stéphane Dalle, Dana M. Hartl, Eric Baudin, Catherine Guettier, Eric Vibert, Olivier Rosmorduc, Caroline Robert, Sophie Ferlicot, Bastien Parier, Laurence Albiges, Vincent Thomas de Montpreville, Benjamin Besse, Olaf Mercier, Caroline Even, Ingrid Breuskin, Marion Classe, Camélia Radulescu, Thierry Lebret, Patricia Pautier, Sébastien Gouy, Jean-Yves Scoazec, Laurence Zitvogel, Aurélien Marabelle, Mélodie Bonvalet

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