Targeting the oncogenic activity of TCF3-HLF in leukemia by Yun Huang, Jean-Pierre Bourquin

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P331: THE ONCOGENIC TRANSCRIPTION FACTOR TCF3::HLF MARKS A DISTINCT ENHANCER-PROMOTER INTERACTION NETWORK IN T(17;19) POSITIVE CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA by Valdemar Priebe, Aneta Drakul, Stefan Zeyen, Beat Bornhauser, Raffaella Santoro, Jean-Pierre Bourquin

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Rapid Generation of Leukemogenic Chromosomal Translocations in Vivo Using CRISPR/Cas9 by Yun Huang, Blerim Marovca, Susanne Dettwiler, Peter Karl Bode, Beat Bornhauser, Jean-Pierre Bourquin

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MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling by Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K. Rauwolf, James Kim, Beat Bornhauser, Jean-Pierre Bourquin

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High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors by Lenka Besse, Andrej Besse, Marianne Kraus, Elmer Maurits, Herman S. Overkleeft, Beat Bornhauser, Jean-Pierre Bourquin, Christoph Driessen

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Humanised mouse models for haematopoiesis and infectious diseases by Veronika Lysenko, Donal McHugh, Lena Behrmann, Mary-Aude Rochat, Christian M. Wilk, Larisa Kovtonyuk, Jean-Pierre Bourquin, Christian Münz, Markus G. Manz, Roberto Speck, Alexandre P.A. Theocharides

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P316: PRIORITIZING PRECISION MEDICINES IN PEDIATRIC BLOOD CANCER: EXPERIENCE OF THE DUTCH INDIVIDUALIZED THERAPY (ITHER) STUDY’S MOLECULAR TUMOR BOARD by Judith M. Boer, Uri Ilan, Babette D.J. Hoen, Aurelie Boeree, Karin P.S. Langenberg, Jan Koster, Jean-Pierre Bourquin, Jan J. Molenaar, Bianca Goemans, Monique L. den Boer, Michel Zwaan

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Other (Non-CNS/Testicular) Extramedullary Localizations of Childhood Relapsed Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma—A Report from the ALL-REZ Study Group by Andrej Lissat, Claudia van Schewick, Ingo G. Steffen, Ayumu Arakawa, Jean-Pierre Bourquin, Birgit Burkhardt, Guenter Henze, Georg Mann, Christina Peters, Lucie Sramkova, Cornelia Eckert, Arend von Stackelberg, Christiane Chen-Santel

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Successful Salvage Chemotherapy with FOLFIRINOX for Recurrent Mixed Acinar Cell Carcinoma and Ductal Adenocarcinoma of the Pancreas in an Adolescent Patient by Sarah Pfrommer, Achim Weber, Philipp Dutkowski, Niklaus G. Schäfer, Beat Müllhaupt, Jean-Pierre Bourquin, Stefan Breitenstein, Bernhard C. Pestalozzi, Frank Stenner, Christoph Renner, Giannicola D'Addario, Hans-Jörg Graf, Alexander Knuth, Pierre-Alain Clavien, Panagiotis Samaras

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Second Relapse of Pediatric Patients with Acute Myeloid Leukemia: A Report on Current Treatment Strategies and Outcome of the AML-BFM Study Group by Mareike Rasche, Emma Steidel, Martin Zimmermann, Jean-Pierre Bourquin, Heidrun Boztug, Iveta Janotova, E. Anders Kolb, Thomas Lehrnbecher, Nils von Neuhoff, Naghmeh Niktoreh, Nora Mühlegger, Lucie Sramkova, Jan Stary, Christiane Walter, Ursula Creutzig, Michael Dworzak, Dirk Reinhardt

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COVID-19 – Impact on Childhood Haematology Patients by Tom F.W. Wolfs, Andishe Attarbaschi, Adriana Balduzzi, Maria Ester Bernardo, Simon Bomken, Arndt Borkhardt, Jean-Pierre Bourquin, Carlo Dufour, Andrew Gennery, John Grainger, Henrik Hasle, Ondrej Hrusak, Shai Izraeli, Francoise Mechinaud, Jan Trka, Josef Vormoor, for the EHA Childhood Hematology SWG

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P330: PROTEOMIC PROFILING UNCOVERS THERAPEUTIC VULNERABILITIES FOR TCF3 TRANSLOCATED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIAS by Rebecca Hasselmann, Lena Blümel, Flavia Bernardi, Daniel Picard, Jacob Torrejon-Diaz, Vera Jepsen, Jasmin Bartl, Nan Qin, Beat Bornhauser, Sanil Bhatia, Blerim Marovca, Veronique Marsaud, Florent Dingli, Damarys Loew, Martin Stanulla, Jean-Pierre Bourquin, Arndt Borkhardt, Marc Remke, Olivier Ayrault, Ute Fischer

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A mass spectrometric-derived cell surface protein atlas. by Damaris Bausch-Fluck, Andreas Hofmann, Thomas Bock, Andreas P Frei, Ferdinando Cerciello, Andrea Jacobs, Hansjoerg Moest, Ulrich Omasits, Rebekah L Gundry, Charles Yoon, Ralph Schiess, Alexander Schmidt, Paulina Mirkowska, Anetta Härtlová, Jennifer E Van Eyk, Jean-Pierre Bourquin, Ruedi Aebersold, Kenneth R Boheler, Peter Zandstra, Bernd Wollscheid

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Survival Following Relapse in Children with Acute Myeloid Leukemia: A Report from AML-BFM and COG by Mareike Rasche, Martin Zimmermann, Emma Steidel, Todd Alonzo, Richard Aplenc, Jean-Pierre Bourquin, Heidrun Boztug, Todd Cooper, Alan S. Gamis, Robert B. Gerbing, Iveta Janotova, Jan-Henning Klusmann, Thomas Lehrnbecher, Nora Mühlegger, Nils v. Neuhoff, Naghmeh Niktoreh, Lucie Sramkova, Jan Stary, Katharina Waack, Christiane Walter, Ursula Creutzig, Michael Dworzak, Gertjan Kaspers, Edward Anders Kolb, Dirk Reinhardt

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S111: TREATMENT OF POST-TRANSPLANT RELAPSE IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS WITH BCP ALL USING CD19-CAR-T: A EUROPEAN RETROSPECTIVE ANALYSIS OF REAL-WORLD DATA by Peter Bader, Anna Alsonso, Andishe Attarbaschi, Nicole Bodmer, Halvard Bonig, Saskia Burridge, Jean-Pierre Bourquin, Veit Bücklein, Gunnar Cario, Macarena Oporto Espuelas, Tobias Feuhtinger, Anna Fuereder, Julia Hauer, Martin Hutter, Krzysztof Kałwak, Annette Künkele, Roland Meisel, Monika Mielcarek-Siedziuk, Ingo Müller, Sara Napolitano, Olaf Penack, Susana Rives, Claudia Rossig, Arend von Stackelberg, Andrea Jarisch, Sara Ghorashian, Adriana Balduzzi

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PDX models recapitulate the genetic and epigenetic landscape of pediatric T‐cell leukemia by Paulina Richter‐Pechańska, Joachim B Kunz, Beat Bornhauser, Caroline vonKnebel Doeberitz, Tobias Rausch, Büşra Erarslan‐Uysal, Yassen Assenov, Viktoras Frismantas, Blerim Marovca, Sebastian M Waszak, Martin Zimmermann, Julia Seemann, Margit Happich, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Martina U Muckenthaler, Jan O Korbel, Jean‐Pierre Bourquin, Andreas E Kulozik

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The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG by Eitan Kugler, Shreyas Madiwale, Darren Yong, Julie A. I. Thoms, Yehudit Birger, David B. Sykes, Johannes Schmoellerl, Aneta Drakul, Valdemar Priebe, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Heather Ogana, Elisabeth Liedke, Jean-Pierre Bourquin, Johannes Zuber, Michael Milyavsky, John Pimanda, Gilbert G. Privé, Shai Izraeli

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Chromatin accessibility landscape of pediatric T‐lymphoblastic leukemia and human T‐cell precursors by Büşra Erarslan‐Uysal, Joachim B Kunz, Tobias Rausch, Paulina Richter‐Pechańska, Ianthe AEM vanBelzen, Viktoras Frismantas, Beat Bornhauser, Diana Ordoñez‐Rueada, Malte Paulsen, Vladimir Benes, Martin Stanulla, Martin Schrappe, Gunnar Cario, Gabriele Escherich, Kseniya Bakharevich, Renate Kirschner‐Schwabe, Cornelia Eckert, Tsvetomir Loukanov, Matthias Gorenflo, Sebastian M Waszak, Jean‐Pierre Bourquin, Martina U Muckenthaler, Jan O Korbel, Andreas E Kulozik

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P676: UPDATED RESULTS FROM THE TRIAL ITCC-054/COG-AAML1921: BOSUTINIB IN NEWLY DIAGNOSED AND RESISTANT/INTOLERANT PEDIATRIC PATIENTS WITH CHRONIC MYELOID LEUKEMIA by Erica Brivio, Edoardo Pennesi, Marieke Willemse, Yilin Jiang, Vincent van der Velden, Berna Beverloo, Chad Hudson, Luke Kuttschreuter, Inge van der Sluis, Benoît Brethon, Francisco Bautista, Michael J. Burke, Nyla Heerema, Andrew Bukowinski, Stacy Cooper, Jessica Pollard, Ramamoorthy Nagasubramani, Michele Redell, Jean-Pierre Bourquin, Ray Pais, Jamie Frediani, Sandeep Batra, Nicoletta Bertorello, Jessica Boklan, Albert Kheradpour, Wade Kyono, Karey Kowalski, Benjamin Mizukawa, Donna Lancaster, Laura Murillo-Sanjuán, Julie Krystal, Yves Bertrand, Alwin Huitema, Harm van Tinteren, Franco Locatelli, Michael Roth, Nobuko Hijiya, Michel Zwaan

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An Extensive Quality Control and Quality Assurance (QC/QA) Program Significantly Improves Inter-Laboratory Concordance Rates of Flow-Cytometric Minimal Residual Disease Assessment... by Margarita Maurer-Granofszky, Angela Schumich, Barbara Buldini, Giuseppe Gaipa, Janos Kappelmayer, Ester Mejstrikova, Leonid Karawajew, Jorge Rossi, Adın Çınar Suzan, Evangelina Agriello, Theodora Anastasiou-Grenzelia, Virna Barcala, Gábor Barna, Drago Batinić, Jean-Pierre Bourquin, Monika Brüggemann, Karolina Bukowska-Strakova, Hasan Burnusuzov, Daniela Carelli, Günnur Deniz, Klara Dubravčić, Tamar Feuerstein, Marie Isabel Gaillard, Adriana Galeano, Hugo Giordano, Alejandro Gonzalez, Stefanie Groeneveld-Krentz, Zsuzsanna Hevessy, Ondrej Hrusak, Maria Belen Iarossi, Pál Jáksó, Veronika Kloboves Prevodnik, Saskia Kohlscheen, Elena Kreminska, Oscar Maglia, Cecilia Malusardi, Neda Marinov, Bibiana Maria Martin, Claudia Möller, Sergey Nikulshin, Jorge Palazzi, Georgios Paterakis, Alexander Popov, Richard Ratei, Cecilia Rodríguez, Elisa Olga Sajaroff, Simona Sala, Gordana Samardzija, Mary Sartor, Pamela Scarparo, Łukasz Sędek, Bojana Slavkovic, Liliana Solari, Peter Svec, Tomasz Szczepanski, Anna Taparkou, Montserrat Torrebadell, Marianna Tzanoudaki, Elena Varotto, Helly Vernitsky, Andishe Attarbaschi, Martin Schrappe, Valentino Conter, Andrea Biondi, Marisa Felice, Myriam Campbell, Csongor Kiss, Giuseppe Basso, Michael N. Dworzak, on behalf of I-BFM-FLOW-Network

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