Modelling of the dilated sagittal sinuses found in multiple sclerosis suggests increased wall stiffness may be a contributing factor by Grant Alexander Bateman, Jeannette Lechner-Scott, Alexander Robert Bateman

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Erythrocyte microRNAs show biomarker potential and implicate multiple sclerosis susceptibility genes by Kira Groen, Vicki E. Maltby, Rodney J. Scott, Lotti Tajouri, Jeannette Lechner‐Scott

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Letter to the editor: blood processing and sample storage have negligible effects on methylation by Kira Groen, Rodney A. Lea, Vicki E. Maltby, Rodney J. Scott, Jeannette Lechner-Scott

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Interferon beta treatment is a potent and targeted epigenetic modifier in multiple sclerosis by Alexandre Xavier, Maria Pia Campagna, Vicki E. Maltby, Vicki E. Maltby, Vicki E. Maltby, Trevor Kilpatrick, Bruce V. Taylor, Helmut Butzkueven, Helmut Butzkueven, Anne-Louise Ponsonby, Rodney J. Scott, Rodney J. Scott, Vilija G. Jokubaitis, Rodney A. Lea, Rodney A. Lea, Jeannette Lechner-Scott, Jeannette Lechner-Scott, Jeannette Lechner-Scott

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3138 Effectiveness of cladribine compared to fingolimod, natalizumab, ocrelizumab and alemtuzumab in relapsing-remitting multiple sclerosis by Nevin John, Tomas Kalincik, Jeannette Lechner-Scott, Suzanne Hodgkinson, Helmut Butzkueven, Michael Barnett, Anneke Van Der Walt, Izanne Roos, Charles Malpas, Katherine Buzzard, Olga Skibina, Sifat Sharmin

3003 Prognostic value of on-treatment serum neurofilament light chain for neT2 lesions relapsing MS patients: pooled analysis of ASCLEPIOS I/II by Jeannette Lechner-Scott, Wenjia Wei, Heinz Wiendl, Xavier Montalban, Stephen L Hauser, Tjalf Ziemssen, Douglas L Arnold, Enrique Alvarez, Tobias Derfuss, Thomas P Leist, Alit Bhatt, Ibolya Boer

The association between disability progression, relapses, and treatment in early relapse onset MS: an observational, multi-centre, longitudinal cohort study by Valery Fuh-Ngwa, Jac C. Charlesworth, Yuan Zhou, Ingrid van der Mei, Phillip E. Melton, Simon A. Broadley, Anne-Louise Ponsonby, Steve Simpson-Yap, Jeannette Lechner-Scott, Bruce V. Taylor

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Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis by Maria Pia Campagna, Alexandre Xavier, Jim Stankovich, Vicki E. Maltby, Mark Slee, Wei Z. Yeh, Trevor Kilpatrick, Rodney J. Scott, Helmut Butzkueven, Jeannette Lechner-Scott, Rodney A. Lea, Vilija G. Jokubaitis

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Efficacy of Cladribine Tablets as a Treatment for People With Multiple Sclerosis: Protocol for the CLOBAS Study (Cladribine, a Multicenter, Long-term Efficacy and Biomarker Austral... by Vicki E Maltby, Rodney A Lea, Mastura Monif, Marzena J Fabis-Pedrini, Katherine Buzzard, Tomas Kalincik, Allan G Kermode, Bruce Taylor, Suzanne Hodgkinson, Pamela McCombe, Helmut Butzkueven, Michael Barnett, Jeannette Lechner-Scott

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Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis by Valery Fuh-Ngwa, Yuan Zhou, Phillip E. Melton, Ingrid van der Mei, Jac C. Charlesworth, Xin Lin, Amin Zarghami, Simon A. Broadley, Anne-Louise Ponsonby, Steve Simpson-Yap, Jeannette Lechner-Scott, Bruce V. Taylor

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CD4+ T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases by Tejaswi V. Badam, Sandra Hellberg, Ratnesh B. Mehta, Jeannette Lechner-Scott, Rodney A. Lea, Jorg Tost, Xavier Mariette, Judit Svensson-Arvelund, Colm E. Nestor, Mikael Benson, Göran Berg, Maria C. Jenmalm, Mika Gustafsson, Jan Ernerudh

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3116 Longitudinal trajectories of digital upper limb biomarkers for multiple sclerosis by Tomas Kalincik, Jeannette Lechner-Scott, Helmut Butzkueven, Trevor Kilpatrick, Robert Hyde, David Darby, Michael Barnett, Anneke Van Der Walt, Yi Chao Foong, Bruce Taylor, Katherine Buzzard, Daniel Merlo, Melissa Gresle, Chao Zhu, Johan van Beek, Pamela Dobay

3115 Longitudinal trajectories of digital cognitive biomarkers for multiple sclerosis by Tomas Kalincik, Jeannette Lechner-Scott, Helmut Butzkueven, Trevor Kilpatrick, Robert Hyde, David Darby, Michael Barnett, Anneke Van Der Walt, Yi Chao Foong, Bruce Taylor, Katherine Buzzard, Daniel Merlo, Melissa Gresle, Chao Zhu, Johan van Beek, Pamela Dobay

3149 Real-world Australian experience with Ofatumumab in the MSBase registry by Nevin John, Tomas Kalincik, Jeannette Lechner-Scott, Mark Slee, Suzanne Hodgkinson, Tim Spelman, Helmut Butzkueven, Michael Barnett, Allan Kermode, Richard Macdonell, Anneke Van Der Walt, Pamela McCombe, Marzena Fabis-Pedrini, William M Carroll, Margaret Migocki, Birte Schmitt

Increased DNA methylation of SLFN12 in CD4+ and CD8+ T cells from multiple sclerosis patients. by Brooke Rhead, Ina S Brorson, Tone Berge, Cameron Adams, Hong Quach, Stine Marit Moen, Pål Berg-Hansen, Elisabeth Gulowsen Celius, Dipen P Sangurdekar, Paola G Bronson, Rodney A Lea, Sean Burnard, Vicki E Maltby, Rodney J Scott, Jeannette Lechner-Scott, Hanne F Harbo, Steffan D Bos, Lisa F Barcellos

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The clinical relevance of MOG antibody testing in cerebrospinal fluid by Molly Reynolds, Irene Tan, Kristy Nguyen, Vera Merheb, Fiona X. Z. Lee, Benjamin P Trewin, Magdalena Lerch, Snehal Shah, Nigel Wolfe, Katherine Buzzard, Jeannette Lechner‐Scott, Marzena Fabis‐Pedrini, Anthony Fok, Nevin John, Chris Kneebone, Con Yiannikas, David A. Brown, Allan G. Kermode, Stephen Reddel, Russell C. Dale, Fabienne Brilot, Sudarshini Ramanathan, the Australasian MOGAD Study Group

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Geographical variations in sex ratio trends over time in multiple sclerosis. by Maria Trojano, Guglielmo Lucchese, Giusi Graziano, Bruce V Taylor, Steve Simpson, Vito Lepore, Francois Grand'maison, Pierre Duquette, Guillermo Izquierdo, Pierre Grammond, Maria Pia Amato, Roberto Bergamaschi, Giorgio Giuliani, Cavit Boz, Raymond Hupperts, Vincent Van Pesch, Jeannette Lechner-Scott, Edgardo Cristiano, Marcela Fiol, Celia Oreja-Guevara, Maria Laura Saladino, Freek Verheul, Mark Slee, Damiano Paolicelli, Carla Tortorella, Mariangela D'Onghia, Pietro Iaffaldano, Vita Direnzo, Helmut Butzkueven, MSBase Study Group and the New Zealand MS Prevalence Study Group

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Country, sex, EDSS change and therapy choice independently predict treatment discontinuation in multiple sclerosis and clinically isolated syndrome. by Claire Meyniel, Timothy Spelman, Vilija G Jokubaitis, Maria Trojano, Guillermo Izquierdo, François Grand'Maison, Celia Oreja-Guevara, Cavit Boz, Alessandra Lugaresi, Marc Girard, Pierre Grammond, Gerardo Iuliano, Marcela Fiol, Jose Antonio Cabrera-Gomez, Ricardo Fernandez-Bolanos, Giorgio Giuliani, Jeannette Lechner-Scott, Edgardo Cristiano, Joseph Herbert, Tatjana Petkovska-Boskova, Roberto Bergamaschi, Vincent van Pesch, Fraser Moore, Norbert Vella, Mark Slee, Vetere Santiago, Michael Barnett, Eva Havrdova, Carolyn Young, Carmen-Adella Sirbu, Mary Tanner, Michelle Rutherford, Helmut Butzkueven, MSBasis Study Group

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Predictors of treatment switching in the Big Multiple Sclerosis Data Network by Tim Spelman, Tim Spelman, Melinda Magyari, Melinda Magyari, Helmut Butzkueven, Helmut Butzkueven, Anneke Van Der Walt, Anneke Van Der Walt, Sandra Vukusic, Sandra Vukusic, Sandra Vukusic, Maria Trojano, Pietro Iaffaldano, Dana Horáková, Jirí Drahota, Fabio Pellegrini, Fabio Pellegrini, Robert Hyde, Pierre Duquette, Jeannette Lechner-Scott, Jeannette Lechner-Scott, Seyed Aidin Sajedi, Patrice Lalive, Vahid Shaygannejad, Serkan Ozakbas, Sara Eichau, Raed Alroughani, Murat Terzi, Marc Girard, Tomas Kalincik, Francois Grand'Maison, Olga Skibina, Samia J. Khoury, Bassem Yamout, Maria Jose Sa, Oliver Gerlach, Yolanda Blanco, Rana Karabudak, Celia Oreja-Guevara, Ayse Altintas, Stella Hughes, Pamela McCombe, Radek Ampapa, Koen de Gans, Chris McGuigan, Aysun Soysal, Julie Prevost, Nevin John, Jihad Inshasi, Leszek Stawiarz, Ali Manouchehrinia, Lars Forsberg, Finn Sellebjerg, Anna Glaser, Luigi Pontieri, Hanna Joensen, Peter Vestergaard Rasmussen, Tobias Sejbaek, Mai Bang Poulsen, Jeppe Romme Christensen, Matthias Kant, Morten Stilund, Morten Stilund, Henrik Mathiesen, Jan Hillert, The Big MS Data Network: a collaboration of the Czech MS Registry, the Danish MS Registry, Italian MS Registry, Swedish MS Registry, MSBase Study Group, and OFSEP

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Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS. by Karen Ann Ribbons, Patrick McElduff, Cavit Boz, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Francois Grand'Maison, Raymond Hupperts, Pierre Grammond, Celia Oreja-Guevara, Thor Petersen, Roberto Bergamaschi, Giorgio Giuliani, Michael Barnett, Vincent van Pesch, Maria-Pia Amato, Gerardo Iuliano, Marcela Fiol, Mark Slee, Freek Verheul, Edgardo Cristiano, Ricardo Fernandez-Bolanos, Maria-Laura Saladino, Maria Edite Rio, Jose Cabrera-Gomez, Helmut Butzkueven, Erik van Munster, Leontien Den Braber-Moerland, Daniele La Spitaleri, Alessandra Lugaresi, Vahid Shaygannejad, Vahid Shaygannejad, Orla Gray, Norma Deri, Raed Alroughani, Jeannette Lechner-Scott

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