Keys to drug sensitivity from updated functional work flows by Stephen E. Kurtz, Jeffrey W. Tyner

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Automated decision tree to evaluate genetic abnormalities when determining prognostic risk in acute myeloid leukemia by Kevin Watanabe-Smith, Brian J. Druker, Jeffrey W. Tyner, David K Edwards

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Immune cell proportions correlate with clinicogenomic features and ex vivo drug responses in acute myeloid leukemia by Kyle A. Romine, Daniel Bottomly, Daniel Bottomly, William Yashar, William Yashar, Nicola Long, Nicola Long, Matthew Viehdorfer, Shannon K. McWeeney, Shannon K. McWeeney, Jeffrey W. Tyner, Jeffrey W. Tyner

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A genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways that mediate resistance to sorafenib in acute myeloid leukemia by Alisa Damnernsawad, Daniel Bottomly, Stephen E. Kurtz, Christopher A. Eide, Shannon K. McWeeney, Jeffrey W. Tyner, Tamilla Nechiporuk

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Treatment for ovarian clear cell carcinoma with combined inhibition of WEE1 and ATR by Wenwen Chien, Jeffrey W. Tyner, Sigal Gery, Yueyuan Zheng, Li-Yan Li, Mohan Shankar Gopinatha Pillai, Chehyun Nam, Neil A. Bhowmick, De-Chen Lin, H. Phillip Koeffler

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Proteolysis targeting chimeric molecules as therapy for multiple myeloma: efficacy, biomarker and drug combinations by Su Lin Lim, Alisa Damnernsawad, Pavithra Shyamsunder, Wee Joo Chng, Bing Chen Han, Liang Xu, Jian Pan, Dakle Pushkar Pravin, Serhan Alkan, Jeffrey W. Tyner, H. Phillip Koeffler

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Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib by Myles Vigoda, Chase Mathieson, Nathaniel Evans, Carolyn Hale, Jennifer Jennings, Olivia Lucero, Sophia Jeng, Daniel Bottomly, Daniel Clayburgh, Peter Andersen, Ryan Li, Daniel Petrisor, Jeffrey W. Tyner, Shannon McWeeney, Molly Kulesz-Martin

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EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT by Akil A. Merchant, Aparna Jorapur, Amy McManus, Ren Liu, Valery Krasnoperov, Parvesh Chaudhry, Mohan Singh, Lisa Harton, Mary Agajanian, Miriam Kim, Timothy J. Triche, Jr, Brian J. Druker, Jeffrey W. Tyner, Parkash S. Gill

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FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells by Nathalie Javidi-Sharifi, Jacqueline Martinez, Isabel English, Sunil K Joshi, Renata Scopim-Ribeiro, Shelton K Viola, David K Edwards V, Anupriya Agarwal, Claudia Lopez, Danielle Jorgens, Jeffrey W Tyner, Brian J Druker, Elie Traer

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Aurora A kinase as a target for therapy in <i>TCF3-HLF</i> rearranged acute lymphoblastic leukemia by Jessica Leonard, Joelle SJ Wolf, Michelle Degnin, Christopher A. Eide, Dorian LaTocha, Kyle Lenz, Beth Wilmot, Charles G. Mullighan, Mignon Loh, Stephen P Hunger, Brian J Druker, Marc M Loriaux, Jeffrey W Tyner, Bill H Chang

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Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia by Brian S. White, Suleiman A. Khan, Mike J. Mason, Muhammad Ammad-ud-din, Swapnil Potdar, Disha Malani, Heikki Kuusanmäki, Brian J. Druker, Caroline Heckman, Olli Kallioniemi, Stephen E. Kurtz, Kimmo Porkka, Cristina E. Tognon, Jeffrey W. Tyner, Tero Aittokallio, Krister Wennerberg, Justin Guinney

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Oncogenic <i>NTRK3</i> mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia by Sunil K. Joshi, Ariane Huang, Janét Pittsenbarger, Ujwal Shinde, Camilo Posso, Paul D. Piehowski, Sara J.C. Gosline, Richard D. Press, Marina A. Gritsenko, Chelsea Hutchinson, Karl K. Weitz, Kevin Watanabe-Smith, Nicola Long, Karin D. Rodland, Jeffrey W. Tyner, Brian J. Druker, Cristina E. Tognon

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A novel AGGF1-PDGFRb fusion in pediatric T-cell acute lymphoblastic leukemia by Matthew S. Zabriskie, Orlando Antelope, Anupam R. Verma, Lauren R. Draper, Christopher A. Eide, Anthony D. Pomicter, Thai Hoa Tran, Brian J. Druker, Jeffrey W. Tyner, Rodney R. Miles, James M. Graham, Jae-Yeon Hwang, Katherine E. Varley, Reha M. Toydemir, Michael W. Deininger, Elizabeth A. Raetz, Thomas O’Hare

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Replication timing alterations in leukemia affect clinically relevant chromosome domains by Juan Carlos Rivera-Mulia, Takayo Sasaki, Claudia Trevilla-Garcia, Naoto Nakamichi, David J. H.F. Knapp, Colin A. Hammond, Bill H. Chang, Jeffrey W. Tyner, Meenakshi Devidas, Jared Zimmerman, Kyle N. Klein, Vivek Somasundaram, Brian J. Druker, Tanja A. Gruber, Amnon Koren, Connie J. Eaves, David M. Gilbert

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Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity by Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen

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