Jens Juul Holst

Jens Juul Holst (born 1 August 1945) is a Danish physician and physiologist. He is known for discovering and describing the hormone glucagon-like peptide-1 (GLP-1), a hormone in the gut that plays an important role in the onset and development of Type 2 diabetes. In collaboration with researcher and author Arne Astrup, he discovered that GLP-1 acts as a satiety hormone in humans.

In 2020, he was awarded the Warren Alpert Foundation Prize along Daniel J. Drucker and Joel F. Habener.

In 2021, he was awarded the Canada Gairdner International Award along Daniel J. Drucker, Joel F. Habener, and Mary-Claire King. He was also awarded the Banting Medal by the American Diabetes Association (ADA).

In 2024, he was awarded the Princess of Asturias Awards for Technical and Scientific Research along Daniel J. Drucker, Jeffrey M. Friedman, Joel F. Habener, and Svetlana Mojsov. In 2024 he received the Tang Prize in the category of "Biopharmaceutical Science", and also in 2024 the BBVA Foundation Frontiers of Knowledge Award in the category "Biology and Biomedicine". Provided by Wikipedia
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  1. 1
    Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches

    Incretin Hormones and Type 2 Diabetes—Mechanistic Insights and Therapeutic Approaches by Geke Aline Boer, Jens Juul Holst

    Published 2020-12-01
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  2. 2
    The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

    The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection by Peter Lindquist, Lærke Smidt Gasbjerg, Jacek Mokrosinski, Jens Juul Holst, Jens Juul Holst, Alexander Sebastian Hauser, Mette Marie Rosenkilde

    Published 2022-06-01
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  3. 3
    The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion

    The Sensory Mechanisms of Nutrient-Induced GLP-1 Secretion by Anna Pii Hjørne, Ida Marie Modvig, Jens Juul Holst

    Published 2022-05-01
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  4. 4
    GLP-1 and Intestinal Diseases

    GLP-1 and Intestinal Diseases by Jenna Elizabeth Hunt, Jens Juul Holst, Palle Bekker Jeppesen, Hannelouise Kissow

    Published 2021-04-01
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  5. 5
    Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones

    Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones by Kent Pedersen, Helle Andersen, Christian Fledelius, Jens Juul Holst, Sara Toftegaard Hjuler, Rune Ehrenreich Kuhre

    Published 2023-03-01
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  6. 6
    The Effect of Dietary Fish Oil in addition to Lifestyle Counselling on Lipid Oxidation and Body Composition in Slightly Overweight Teenage Boys

    The Effect of Dietary Fish Oil in addition to Lifestyle Counselling on Lipid Oxidation and Body Composition in Slightly Overweight Teenage Boys by Maiken Højgaard Pedersen, Christian Mølgaard, Lars Ingvar Hellgren, Jeppe Matthiessen, Jens Juul Holst, Lotte Lauritzen

    Published 2011-01-01
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  7. 7
    Increased postprandial glycaemia, insulinemia, and lipidemia after 10 weeks’ sucrose-rich diet compared to an artificially sweetened diet: a randomised controlled trial

    Increased postprandial glycaemia, insulinemia, and lipidemia after 10 weeks’ sucrose-rich diet compared to an artificially sweetened diet: a randomised controlled trial by Arne Astrup, Jens Juul Holst, A. Christina Møller, Tatjana H. Vasilaris, Anne Flint, Bente K. Møller, Anne Raben

    Published 2011-07-01
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  8. 8
    The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3

    The Severity of DSS-Induced Colitis Is Independent of the SCFA-FFAR2/3-GLP-1 Pathway Despite SCFAs Inducing GLP-1 Secretion via FFAR2/3 by Jenna Elizabeth Hunt, Charlotte Bayer Christiansen, Mohammad Yassin, Bolette Hartmann, Stefan Offermanns, Lars Ove Dragsted, Jens Juul Holst, Hannelouise Kissow

    Published 2024-07-01
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  9. 9
    Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography

    Exploring the GLP-1–GLP-1R axis in porcine pancreas and gastrointestinal tract in vivo by ex vivo autoradiography by Jens Juul Holst, Elin Manell, Emmi Puuvuori, Anna Svensson, Irina Velikyan, Gry Hulsart-Billström, Patricia Hedenqvist, Marianne Jensen Waern, Olof Eriksson

    Published 2021-03-01
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  10. 10
    l-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels

    l-valine is a powerful stimulator of GLP-1 secretion in rodents and stimulates secretion through ATP-sensitive potassium channels and voltage-gated calcium channels by Ida Marie Modvig, Mark M. Smits, Katrine Douglas Galsgaard, Anna Pii Hjørne, Anna Katarzyna Drzazga, Mette Marie Rosenkilde, Jens Juul Holst

    Published 2024-06-01
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  11. 11
    A Pilot Study Showing Acute Inhibitory Effect of GLP‐1 on the Bone Resorption Marker CTX in Humans

    A Pilot Study Showing Acute Inhibitory Effect of GLP‐1 on the Bone Resorption Marker CTX in Humans by Anne Nissen, Simone Marstrand, Kirsa Skov‐Jeppesen, Lasse Bremholm, Mads Hornum, Ulrik B Andersen, Jens Juul Holst, Mette Marie Rosenkilde, Bolette Hartmann

    Published 2019-10-01
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  12. 12
    Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery

    Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery by Roberto Visentin, Katrine Brodersen, Bjørn Richelsen, Niels Møller, Chiara Dalla Man, Andreas Kristian Pedersen, Jan Abrahamsen, Jens Juul Holst, Michael Festersen Nielsen

    Published 2023-01-01
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  13. 13
    Sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with short bowel syndrome and colon in continuity: an open-label pilot study

    Sitagliptin, a dipeptidyl peptidase-4 inhibitor, in patients with short bowel syndrome and colon in continuity: an open-label pilot study by Bolette Hartmann, Jens Juul Holst, Rahim Mohammad Naimi, Mark Krogh Hvistendahl, Lise Margrete Thomassen, Hanna Johnsen, Charlotte Bayer Christiansen, Palle Bekker Jeppesen

    Published 2021-10-01
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  14. 14
    Endogenous incretin levels and risk of first incident cancer: a prospective cohort study

    Endogenous incretin levels and risk of first incident cancer: a prospective cohort study by Amra Jujić, Christopher Godina, Mattias Belting, Olle Melander, Jens Juul Holst, Emma Ahlqvist, Maria F. Gomez, Peter M. Nilsson, Helena Jernström, Martin Magnusson

    Published 2023-01-01
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  15. 15
    Unravelling Effects of Rosemary (<i>Rosmarinus officinalis</i> L.) Extract on Hepatic Fat Accumulation and Plasma Lipid Profile in Rats Fed a High-Fat Western-Style Diet

    Unravelling Effects of Rosemary (<i>Rosmarinus officinalis</i> L.) Extract on Hepatic Fat Accumulation and Plasma Lipid Profile in Rats Fed a High-Fat Western-Style Diet by Sidsel Madsen, Steffen Yde Bak, Christian Clement Yde, Henrik Max Jensen, Tine Ahrendt Knudsen, Cecilie Bæch-Laursen, Jens Juul Holst, Christoffer Laustsen, Mette Skou Hedemann

    Published 2023-08-01
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  16. 16
    Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels

    Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels by Kirsten K. Ahring, Allan M. Lund, Erik Jensen, Thomas G. Jensen, Karen Brøndum-Nielsen, Michael Pedersen, Allan Bardow, Jens Juul Holst, Jens F. Rehfeld, Lisbeth B. Møller

    Published 2018-01-01
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  17. 17
    Investigating the roles of hyperglycaemia, hyperinsulinaemia and elevated free fatty acids in cardiac function in patients with type 2 diabetes via treatment with insulin compared with empagliflozin: protocol for the HyperCarD2 randomised, crossover trial

    Investigating the roles of hyperglycaemia, hyperinsulinaemia and elevated free fatty acids in cardiac function in patients with type 2 diabetes via treatment with insulin compared... by Jens Juul Holst, Sten Madsbad, Niels Vejlstrup, Ulrik Dixen, Mogens Fenger, Per Lav Madsen, Jens Peter Goetze, Roopameera Thirumathyam, Erik Arne Richter, Gerrit Van Hall, Nils Bruun Jørgensen

    Published 2022-08-01
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  18. 18
    The role of empagliflozin-induced metabolic changes for cardiac function in patients with type 2 diabetes. A randomized cross-over magnetic resonance imaging study with insulin as comparator

    The role of empagliflozin-induced metabolic changes for cardiac function in patients with type 2 diabetes. A randomized cross-over magnetic resonance imaging study with insulin as... by Roopameera Thirumathyam, Erik Arne Richter, Gerrit van Hall, Jens Juul Holst, Mogens Fenger, Jens P. Gøtze, Ulrik Dixen, Niels Vejlstrup, Sten Madsbad, Per Lav Madsen, Nils Bruun Jørgensen

    Published 2024-01-01
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  19. 19
    Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial

    Prolonged lipopolysaccharide‐induced illness elevates glucagon‐like peptide‐1 and suppresses peptide YY: A human‐randomized cross‐over trial by Katrine Brodersen, Maike Mose, Ulla Ramer Mikkelsen, Jens Otto Lunde Jørgensen, Michael Festersen Nielsen, Niels Møller, Anne‐Marie Wegeberg, Christina Brock, Bolette Hartmann, Jens Juul Holst, Nikolaj Rittig

    Published 2022-09-01
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  20. 20
    Nonalcoholic Fatty Liver Disease Impairs the Liver–Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis

    Nonalcoholic Fatty Liver Disease Impairs the Liver–Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis by Julie Steen Pedersen, Marte Opseth Rygg, Viggo Bjerregaard Kristiansen, Beth Hærstedt Olsen, Reza Rafiolsadat Serizawa, Jens Juul Holst, Sten Madsbad, Lise Lotte Gluud, Flemming Bendtsen, Nicolai Jacob Wewer Albrechtsen

    Published 2020-11-01
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