Beneficial and Detrimental Effects of Reactive Oxygen Species on Lifespan: A Comprehensive Review of Comparative and Experimental Studies by Hazel J. Shields, Hazel J. Shields, Hazel J. Shields, Annika Traa, Annika Traa, Annika Traa, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk

Get full text

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. by Jeremy M Van Raamsdonk, Siegfried Hekimi

Get full text

RNA Sequencing of Pooled Samples Effectively Identifies Differentially Expressed Genes by Bokang Ko, Jeremy M. Van Raamsdonk

Get full text

Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity by Abdelrahman AlOkda, Jeremy M. Van Raamsdonk

Get full text

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease by Megan M. Senchuk, Jeremy M. Van Raamsdonk, Darren J. Moore

Get full text

Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants by Annika Traa, Annika Traa, Annika Traa, Hazel Shields, Hazel Shields, Hazel Shields, Abdelrahman AlOkda, Abdelrahman AlOkda, Abdelrahman AlOkda, Zenith D. Rudich, Zenith D. Rudich, Zenith D. Rudich, Bokang Ko, Bokang Ko, Bokang Ko, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk, Jeremy M. Van Raamsdonk

Get full text

Oxidative stress is increased in C. elegans models of Huntington’s disease but does not contribute to polyglutamine toxicity phenotypes by Emily Machiela, Dylan J. Dues, Megan M. Senchuk, Jeremy M. Van Raamsdonk

Get full text

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation by Annika Traa, Emily Machiela, Paige D. Rudich, Sonja K. Soo, Megan M. Senchuk, Jeremy M. Van Raamsdonk

Get full text

Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants by Namastheé Harris-Gauthier, Annika Traa, Abdelrahman AlOkda, Alibek Moldakozhayev, Ulrich Anglas, Sonja K. Soo, Jeremy M. Van Raamsdonk

Get full text

The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan. by İçten Meraş, Laëtitia Chotard, Thomas Liontis, Zakaria Ratemi, Benjamin Wiles, Jung Hwa Seo, Jeremy M Van Raamsdonk, Christian E Rocheleau

Get full text

Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. by Claire E Schaar, Dylan J Dues, Katie K Spielbauer, Emily Machiela, Jason F Cooper, Megan Senchuk, Siegfried Hekimi, Jeremy M Van Raamsdonk

Get full text

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways by Ziyun Wu, Megan M. Senchuk, Dylan J. Dues, Benjamin K. Johnson, Jason F. Cooper, Leira Lew, Emily Machiela, Claire E. Schaar, Heather DeJonge, T. Keith Blackwell, Jeremy M. Van Raamsdonk

Get full text

Testicular degeneration in Huntington disease by Jeremy M. Van Raamsdonk, Zoe Murphy, David M. Selva, Reza Hamidizadeh, Jacqueline Pearson, Ǻsa Petersén, Maria Björkqvist, Cameron Muir, Ian R. Mackenzie, Geoffrey L. Hammond, A. Wayne Vogl, Michael R. Hayden, Blair R. Leavitt

Get full text