Protocol for Comprehensive Synthetic Lethality Screens by Damia Romero-Moya, Jeroen P. Roose

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Regulation of Ras exchange factors and cellular localization of Ras activation by lipid messengers in T cells by Jesse E. Jun, Ignacio eRubio, Jeroen P. Roose

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Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer by Alexandr Samocha, Hanna Doh, Kai Kessenbrock, Jeroen P. Roose

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Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells by Darienne R. Myers, Emilia Norlin, Yvonne Vercoulen, Jeroen P. Roose

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Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models by P. Jonathan Li, Jeroen P. Roose, David M. Jablons, Johannes R. Kratz

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Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. by Evan Markegard, Evan Trager, Chih-wen Ou Yang, Weiguo Zhang, Arthur Weiss, Jeroen P Roose

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Protocol for Barcoding T Cells Combined with Timed Stimulations by Kayla R. Kulhanek, Darienne R. Myers, Olga Ksionda, Yvonne Vercoulen, Damia Romero-Moya, Jeroen P. Roose

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A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1 by Yvonne Vercoulen, Yasushi Kondo, Jeffrey S Iwig, Axel B Janssen, Katharine A White, Mojtaba Amini, Diane L Barber, John Kuriyan, Jeroen P Roose

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Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1 by Jeffrey S Iwig, Yvonne Vercoulen, Rahul Das, Tiago Barros, Andre Limnander, Yan Che, Jeffrey G Pelton, David E Wemmer, Jeroen P Roose, John Kuriyan

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Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy. by Olga Ksionda, Marsilius Mues, Anica M Wandler, Lisa Donker, Milou Tenhagen, Jesse Jun, Gregory S Ducker, Ksenia Matlawska-Wasowska, Kevin Shannon, Kevan M Shokat, Jeroen P Roose

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High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions by Marsilius Mues, Laila Karra, Damia Romero-Moya, Anica Wandler, Matthew J. Hangauer, Olga Ksionda, Yvonne Thus, Marthe Lindenbergh, Kevin Shannon, Michael T. McManus, Jeroen P. Roose

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Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells by Darienne R. Myers, Tannia Lau, Evan Markegard, Hyung W. Lim, Herbert Kasler, Minghua Zhu, Andrea Barczak, John P. Huizar, Julie Zikherman, David J. Erle, Weiguo Zhang, Eric Verdin, Jeroen P. Roose

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Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies by Stephen R Daley, Kristen M Coakley, Daniel Y Hu, Katrina L Randall, Craig N Jenne, Andre Limnander, Darienne R Myers, Noelle K Polakos, Anselm Enders, Carla Roots, Bhavani Balakishnan, Lisa A Miosge, Geoff Sjollema, Edward M Bertram, Matthew A Field, Yunli Shao, T Daniel Andrews, Belinda Whittle, S Whitney Barnes, John R Walker, Jason G Cyster, Christopher C Goodnow, Jeroen P Roose

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