CAR T-Cells in Multiple Myeloma Are Ready for Prime Time by Paula Rodríguez-Otero, Felipe Prósper, Ana Alfonso, Bruno Paiva, Jesús F. San Miguel

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Measurable residual disease in multiple myeloma: ready for clinical practice? by Leire Burgos, Noemi Puig, Maria-Teresa Cedena, María-Victoria Mateos, Juan José Lahuerta, Bruno Paiva, Jesús F. San-Miguel

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Deficient spindle assembly checkpoint in multiple myeloma. by Elena Díaz-Rodríguez, Stela Álvarez-Fernández, Xi Chen, Bruno Paiva, Ricardo López-Pérez, Juan Luis García-Hernández, Jesús F San Miguel, Atanasio Pandiella

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Bone marrow mesenchymal stem cells for improving hematopoietic function: an in vitro and in vivo model. Part 2: Effect on bone marrow microenvironment. by Soraya Carrancio, Belen Blanco, Carlos Romo, Sandra Muntion, Natalia Lopez-Holgado, Juan F Blanco, Jesus G Briñon, Jesus F San Miguel, Fermin M Sanchez-Guijo, M Consuelo del Cañizo

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Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development by Mª Carmen Herrero-Sánchez, Concepción Rodríguez-Serrano, Julia Almeida, Laura San Segundo, Susana Inogés, Ángel Santos-Briz, Jesús García-Briñón, Luis Antonio Corchete, Jesús F. San Miguel, Consuelo del Cañizo, Belén Blanco

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The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients by Sara Villar, Sara Villar, Beñat Ariceta, Beñat Ariceta, Beñat Ariceta, Xabier Agirre, Xabier Agirre, Aura Daniela Urribarri, Rosa Ayala, David Martínez-Cuadrón, Juan Miguel Bergua, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martínez, Josefina Serrano, Catia Simoes, Pilar Herrera, Maria José Calasanz, Maria José Calasanz, Ana Alfonso-Piérola, Ana Alfonso-Piérola, Bruno Paiva, Bruno Paiva, Bruno Paiva, Joaquín Martínez-López, Jesús F. San Miguel, Jesús F. San Miguel, Felipe Prósper, Felipe Prósper, Pau Montesinos

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Both CD133 Cells and Monocytes Provide Significant Improvement for Hindlimb Ischemia, Although They do not Transdifferentiate Into Endothelial Cells by Fermin M. Sanchez-Guijo M.D., PhD., Enrique Oterino, Maria-Victoria Barbado, Soraya Carrancio, Natalia Lopez-Holgado, Sandra Muntion, Pilar Hernandez-Campo, Luis-Ignacio Sanchez-Abarca, Jose A. Perez-Simon, Jesús F. San Miguel, Jesús G. Briñon, Maria-Consuelo Del Cañizo

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Reference Values to Assess Hemodilution and Warn of Potential False-Negative Minimal Residual Disease Results in Myeloma by Noemí Puig, Juan Flores-Montero, Leire Burgos, María-Teresa Cedena, Lourdes Cordón, José-Juan Pérez, Luzalba Sanoja-Flores, Irene Manrique, Paula Rodríguez-Otero, Laura Rosiñol, Joaquín Martínez-López, María-Victoria Mateos, Juan-José Lahuerta, Joan Bladé, Jesús F. San Miguel, Alberto Orfao, Bruno Paiva

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P848: EXPRESSION PROFILE OF BCL-2 FAMILY PROTEINS IN MULTIPLE MYELOMA. by Cristina De Ramón Sánchez, Elizabeta A Rojas, Irena Misiewicz-Krzeminska, Ignacio J Cardona-Benavides, Myriam Cuadrado, Isabel Isidro, Maria Jose Calasanz, Ramón García-Sanz, Laura Rosiñol Dachs, Joaquín Martinez-Lopez, Joan Baldé, Juan J Lahuerta, Jesus F San Miguel, Maria-Victoria Mateos, Luis A Corchete, Norma Carmen Gutierrez Gutierrez

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Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair by Ana-Alicia López-Iglesias, Ana B. Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P. Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F. San-Miguel, María-Victoria Mateos, Norma C. Gutiérrez, Mercedes Garayoa, Enrique M. Ocio

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Pembrolizumab as Consolidation Strategy in Patients with Multiple Myeloma: Results of the GEM-Pembresid Clinical Trial by Noemí Puig, Luis A. Corchete-Sánchez, José J. Pérez-Morán, Julio Dávila, Teresa Paíno, Javier de la Rubia, Albert Oriol, Jesús Martín-Sánchez, Felipe de Arriba, Joan Bladé, María-Jesús Blanchard, Verónica González-Calle, Ramón García-Sanz, Bruno Paiva, Juan-José Lahuerta, Jesús F. San-Miguel, María-Victoria Mateos, Enrique M. Ocio

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The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma by Yuji Mishima, Bruno Paiva, Jiantao Shi, Jihye Park, Salomon Manier, Satoshi Takagi, Mira Massoud, Adriana Perilla-Glen, Yosra Aljawai, Daisy Huynh, Aldo M. Roccaro, Antonio Sacco, Marzia Capelletti, Alexandre Detappe, Diego Alignani, Kenneth C. Anderson, Nikhil C. Munshi, Felipe Prosper, Jens G. Lohr, Gavin Ha, Samuel S. Freeman, Eliezer M. Van Allen, Viktor A. Adalsteinsson, Franziska Michor, Jesus F. San Miguel, Irene M. Ghobrial

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Insights on Multiple Myeloma Treatment Strategies by María-Victoria Mateos, Heinz Ludwig, Ali Bazarbachi, Meral Beksac, Joan Bladé, Mario Boccadoro, Michele Cavo, Michel Delforge, Meletios A. Dimopoulos, Thierry Facon, Catarina Geraldes, Hartmut Goldschmidt, Roman Hájek, Markus Hansson, Krzysztof Jamroziak, Merav Leiba, Tamás Masszi, Larisa Mendeleeva, Michael O’Dwyer, Torben Plesner, Jesús F. San-Miguel, Christian Straka, Niels W.C.J. van de Donk, Kwee Yong, Samo Zver, Philippe Moreau, Pieter Sonneveld

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NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial by Juan Manuel Rosa-Rosa, Isabel Cuenca, Alejandro Medina, Iria Vázquez, Andrea Sánchez-delaCruz, Natalia Buenache, Ricardo Sánchez, Cristina Jiménez, Laura Rosiñol, Norma C. Gutiérrez, Yanira Ruiz-Heredia, Santiago Barrio, Albert Oriol, Maria-Luisa Martin-Ramos, María-Jesús Blanchard, Rosa Ayala, Rafael Ríos-Tamayo, Anna Sureda, Miguel-Teodoro Hernández, Javier de la Rubia, Gorka Alkorta-Aranburu, Xabier Agirre, Joan Bladé, María-Victoria Mateos, Juan-José Lahuerta, Jesús F. San-Miguel, María-José Calasanz, Ramón Garcia-Sanz, Joaquín Martínez-Lopez

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Lenalidomide and dexamethasone with or without clarithromycin in patients with multiple myeloma ineligible for autologous transplant: a randomized trial by Noemi Puig, Miguel T. Hernández, Laura Rosiñol, Esther González, Felipe de Arriba, Albert Oriol, Verónica González-Calle, Fernando Escalante, Javier de la Rubia, Mercedes Gironella, Rafael Ríos, Ricarda García-Sánchez, José M. Arguiñano, Adrián Alegre, Jesús Martín, Norma. C. Gutiérrez, María J. Calasanz, María L. Martín, María del Carmen Couto, María Casanova, Mario Arnao, Ernesto Pérez-Persona, Sebastián Garzón, Marta S. González, Guillermo Martín-Sánchez, Enrique M. Ocio, Morton Coleman, Cristina Encinas, Ana M. Vale, Ana I. Teruel, María Cortés-Rodríguez, Bruno Paiva, M. Teresa Cedena, Jesús F. San-Miguel, Juan J. Lahuerta, Joan Bladé, Ruben Niesvizky, María-Victoria Mateos

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Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance by Cirino Botta, Cristina Perez, Marta Larrayoz, Noemi Puig, Maria-Teresa Cedena, Rosalinda Termini, Ibai Goicoechea, Sara Rodriguez, Aintzane Zabaleta, Aitziber Lopez, Sarai Sarvide, Laura Blanco, Daniele M. Papetti, Marco S. Nobile, Daniela Besozzi, Massimo Gentile, Pierpaolo Correale, Sergio Siragusa, Albert Oriol, Maria Esther González-Garcia, Anna Sureda, Felipe de Arriba, Rafael Rios Tamayo, Jose-Maria Moraleda, Mercedes Gironella, Miguel T. Hernandez, Joan Bargay, Luis Palomera, Albert Pérez-Montaña, Hartmut Goldschmidt, Hervé Avet-Loiseau, Aldo Roccaro, Alberto Orfao, Joaquin Martinez-Lopez, Laura Rosiñol, Juan-José Lahuerta, Joan Blade, Maria-Victoria Mateos, Jesús F. San-Miguel, Jose-Angel Martinez Climent, Bruno Paiva, the Programa Para el Estudio de la Terapéutica en Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) cooperative group, the iMMunocell study group

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A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma by Cristina Encinas, José-Ángel Hernandez-Rivas, Albert Oriol, Laura Rosiñol, María-Jesús Blanchard, José-María Bellón, Ramón García-Sanz, Javier de la Rubia, Ana López de la Guía, Ana Jímenez-Ubieto, Isidro Jarque, Belén Iñigo, Victoria Dourdil, Felipe de Arriba, Clara Cuéllar Pérez-Ávila, Yolanda Gonzalez, Miguel-Teodoro Hernández, Joan Bargay, Miguel Granell, Paula Rodríguez-Otero, Maialen Silvent, Carmen Cabrera, Rafael Rios, Adrián Alegre, Mercedes Gironella, Marta-Sonia Gonzalez, Anna Sureda, Antonia Sampol, Enrique M. Ocio, Isabel Krsnik, Antonio García, Aránzazu García-Mateo, Joan-Alfons Soler, Jesús Martín, José-María Arguiñano, María-Victoria Mateos, Joan Bladé, Jesús F. San-Miguel, Juan-José Lahuerta, Joaquín Martínez-López, GEM/PETHEMA (Grupo Español de Mieloma/Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study group

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