New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An Update by Adrián Montaño, Maribel Forero-Castro, Darnel Marchena-Mendoza, Rocío Benito, Jesús María Hernández-Rivas

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Targeted genome editing in acute lymphoblastic leukemia: a review by Adrián Montaño, Maribel Forero-Castro, Jesús-María Hernández-Rivas, Ignacio García-Tuñón, Rocío Benito

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Clinical, cytogenetic, and molecular findings in a patient with ring chromosome 4: case report and literature review by César Paz-y-Miño, Ana Proaño, Stella D. Verdezoto, Juan Luis García, Jesús María Hernández-Rivas, Paola E. Leone

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Alteration in endoglin-related angiogenesis in refractory cytopenia with multilineage dysplasia. by Mónica del Rey, Miguel Pericacho, Soraya Velasco, Eva Lumbreras, José Miguel López-Novoa, Jesús María Hernández-Rivas, Alicia Rodríguez-Barbero

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<i>ETV6</i>/<i>RUNX1</i> Fusion Gene Abrogation Decreases the Oncogenicity of Tumour Cells in a Preclinical Model of Acute Lymphoblastic Leukaemia by Adrián Montaño, Jose Luis Ordoñez, Verónica Alonso-Pérez, Jesús Hernández-Sánchez, Sandra Santos, Teresa González, Rocío Benito, Ignacio García-Tuñón, Jesús María Hernández-Rivas

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The Evolving Landscape of Chronic Lymphocytic Leukemia on Diagnosis, Prognosis and Treatment by Claudia Pérez-Carretero, Isabel González-Gascón-y-Marín, Ana E. Rodríguez-Vicente, Miguel Quijada-Álamo, José-Ángel Hernández-Rivas, María Hernández-Sánchez, Jesús María Hernández-Rivas

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Transcriptomic analysis of patients with immune thrombocytopenia treated with eltrombopag by Jesús María Hernández-Sánchez, José María Bastida, Diego Alonso-López, Rocío Benito, José Ramón González-Porras, Javier De Las Rivas, Jesús María Hernández Rivas, Ana Eugenia Rodríguez-Vicente

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Mutational Profile Enables the Identification of a High-Risk Subgroup in Myelodysplastic Syndromes with Isolated Trisomy 8 by Sofía Toribio-Castelló, Sandra Castaño, Ángela Villaverde-Ramiro, Esperanza Such, Montserrat Arnán, Francesc Solé, Marina Díaz-Beyá, María Díez-Campelo, Mónica del Rey, Teresa González, Jesús María Hernández-Rivas

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NEMHESYS—European Perspective on the Implementation of Next-generation Sequencing Into Clinical Diagnostics by Inmaculada Serramito-Gómez, Kathryn M. Clarke, Ana Eugenia Rodríguez-Vicente, Julie E. McGimpsey, María Abáigar, Carlos Barranquero Díez, Rocío Benito, Lars Bullinger, Ken I. Mills, Jesús María Hernández Rivas

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Splice donor site sgRNAs enhance CRISPR/Cas9-mediated knockout efficiency. by Ignacio García-Tuñón, Verónica Alonso-Pérez, Elena Vuelta, Sandra Pérez-Ramos, María Herrero, Lucía Méndez, Jesús María Hernández-Sánchez, Marta Martín-Izquierdo, Raquel Saldaña, Julián Sevilla, Fermín Sánchez-Guijo, Jesús María Hernández-Rivas, Manuel Sánchez-Martín

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Identification of two novel mutations in RASGRP2 affecting platelet CalDAG-GEFI expression and function in patients with bleeding diathesis by Teresa Sevivas, José María Bastida, David S. Paul, Eva Caparros, Verónica Palma-Barqueros, Margarida Coucelo, Dalila Marques, Francisca Ferrer-Marín, José Ramón González-Porras, Vicente Vicente, Jesús María Hernández-Rivas, Steve P. Watson, María Luisa Lozano, Wolfgang Bergmeier, José Rivera

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Covering Hierarchical Dirichlet Mixture Models on binary data to enhance genomic stratifications in onco-hematology. by Daniele Dall'Olio, Eric Sträng, Amin T Turki, Jesse M Tettero, Martje Barbus, Renate Schulze-Rath, Javier Martinez Elicegui, Tommaso Matteuzzi, Alessandra Merlotti, Luciana Carota, Claudia Sala, Matteo G Della Porta, Enrico Giampieri, Jesús María Hernández-Rivas, Lars Bullinger, Gastone Castellani, with the HARMONY Healthcare Alliance Consortium

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Hematopoietic stem cells with granulo-monocytic differentiation state overcome venetoclax sensitivity in patients with myelodysplastic syndromes by Juan Jose Rodriguez-Sevilla, Irene Ganan-Gomez, Feiyang Ma, Kelly Chien, Monica Del Rey, Sanam Loghavi, Guillermo Montalban-Bravo, Vera Adema, Bethany Wildeman, Rashmi Kanagal-Shamanna, Alexandre Bazinet, Helen T. Chifotides, Natthakan Thongon, Xavier Calvo, Jesús María Hernández-Rivas, Maria Díez-Campelo, Guillermo Garcia-Manero, Simona Colla

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Outcomes and effect of somatic mutations after erythropoiesis stimulating agents in patients with lower-risk myelodysplastic syndromes by Juan Carlos Caballero, Julio Dávila, María López-Pavía, Esperanza Such, Teresa Bernal, Fernando Ramos, Marisa Calabuig, Jesús María Hernández Sánchez, Helena Pomares, Mercedes Sánchez Barba, María Abáigar, Bernardo González, Brayan Merchán, Reyes Sancho-Tello, Marta Callejas, Carolina Muñoz-Novas, Carlos Cerveró, Guillermo Sanz, Jesús María Hernández Rivas, María Díez Campelo;

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Expert consensus on the use of systemic glucocorticoids for managing eosinophil-related diseases by Victoria del Pozo, Irina Bobolea, Manuel J. Rial, Manuel J. Rial, Georgina Espigol-Frigolé, Roser Solans Laqué, Jesús María Hernández-Rivas, Elvira Mora, Astrid Crespo-Lessmann, José Luis Izquierdo Alonso, José Luis Izquierdo Alonso, María Sandra Domínguez Sosa, Juan Maza-Solano, Belén Atienza-Mateo, David Bañas-Conejero, Abraham L. Moure, Íñigo Rúa-Figueroa

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Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression by Miguel Quijada-Álamo, María Hernández-Sánchez, Ana-Eugenia Rodríguez-Vicente, Claudia Pérez-Carretero, Alberto Rodríguez-Sánchez, Marta Martín-Izquierdo, Verónica Alonso-Pérez, Ignacio García-Tuñón, José María Bastida, María Jesús Vidal-Manceñido, Josefina Galende, Carlos Aguilar, José Antonio Queizán, Isabel González-Gascón y Marín, José-Ángel Hernández-Rivas, Rocío Benito, José Luis Ordóñez, Jesús-María Hernández-Rivas

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Dissecting the role of TP53 alterations in del(11q) chronic lymphocytic leukemia by Miguel Quijada‐Álamo, Claudia Pérez‐Carretero, María Hernández‐Sánchez, Ana‐Eugenia Rodríguez‐Vicente, Ana‐Belén Herrero, Jesús‐María Hernández‐Sánchez, Marta Martín‐Izquierdo, Sandra Santos‐Mínguez, Mónica del Rey, Teresa González, Araceli Rubio‐Martínez, Alfonso García de Coca, Julio Dávila‐Valls, José‐Ángel Hernández‐Rivas, Helen Parker, Jonathan C. Strefford, Rocío Benito, José‐Luis Ordóñez, Jesús‐María Hernández‐Rivas

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Comprehensive Custom NGS Panel Validation for the Improvement of the Stratification of B-Acute Lymphoblastic Leukemia Patients by Adrián Montaño, Jesús Hernández-Sánchez, Maribel Forero-Castro, María Matorra-Miguel, Eva Lumbreras, Cristina Miguel, Sandra Santos, Valentina Ramírez-Maldonado, José Luís Fuster, Natalia de Las Heras, Alfonso García-de Coca, Magdalena Sierra, Julio Dávila, Ignacio de la Fuente, Carmen Olivier, Juan Olazabal, Joaquín Martínez, Nerea Vega-García, Teresa González, Jesús María Hernández-Rivas, Rocío Benito

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S213: BMS-986158, A POTENT BET INHIBITOR, AS MONOTHERAPY AND IN COMBINATION WITH RUXOLITINIB OR FEDRATINIB IN INTERMEDIATE- OR HIGH-RISK MYELOFIBROSIS (MF): RESULTS FROM A PHASE 1/... by Rosa Ayala, Nieves Lopez, Adi Shacham Abulafia, Maan Alwan, Costas K. Yannakou, Indu Raman, Vincent Ribrag, Chun Yew Fong, Yulia Volchek, Massimiliano Bonifacio, Alessandra Tucci, Jean-Jacques Kiladjian, Jésus Marïa Hernandez Rivas, Blanca Xicoy, Haifa Kathrin Al-Ali, Jean-Christope Ianotto, Si Tuen Lee-Hoeflich, Sharmilla Das, Bin Wu, Palanikumar Ravindran, Qian Zhao, Guan Wang, Oriana Esposito, Yu Liu, Zariana Nikolova, Christopher Tehlirian, Shodeinde Coker, David Lavie

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Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia by Miguel Quijada-Álamo, María Hernández-Sánchez, Cristina Robledo, Jesús-María Hernández-Sánchez, Rocío Benito, Adrián Montaño, Ana E. Rodríguez-Vicente, Dalia Quwaider, Ana-África Martín, María García-Álvarez, María Jesús Vidal-Manceñido, Gonzalo Ferrer-Garrido, María-Pilar Delgado-Beltrán, Josefina Galende, Juan-Nicolás Rodríguez, Guillermo Martín-Núñez, José-María Alonso, Alfonso García de Coca, José A. Queizán, Magdalena Sierra, Carlos Aguilar, Alexander Kohlmann, José-Ángel Hernández, Marcos González, Jesús-María Hernández-Rivas

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