Improving the management of multimorbidity in general practice: protocol of a cluster randomised controlled trial (The 3D Study) by Alison Shaw, Peter Bower, Bruce Guthrie, Imran Rafi, Sara Brookes, Joanna Thorn, Chris Salisbury, Cindy Mann, Mei-See Man, Katherine Chaplin, Bridie Fitzpatrick, Sandra Hollinghurst, Stewart Mercer

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Cost-effectiveness of a patient-centred approach to managing multimorbidity in primary care: a pragmatic cluster randomised controlled trial by Peter Bower, Bruce Guthrie, Stewart W Mercer, Daisy Gaunt, Sara Brookes, Joanna Thorn, Chris Salisbury, Mei-See Man, Katherine Chaplin, Bridie Fitzpatrick, Caroline Gardner, Sandra Hollinghurst, Victoria Lee

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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study by Paul Ewings, Emma Dures, Sarah Hewlett, Joanna Thorn, Mwidimi Ndosi, Siobhan Creanor, Jo Adams, Lance M McCracken, Joe Lomax, Susan Bridgewater, Bryan Abbott, Alice Berry, Marie Urban

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A pragmatic cluster randomised controlled trial of air filtration to prevent symptomatic winter respiratory infections (including COVID-19) in care homes (AFRI-c) in England: Trial... by Rachel C M Brierley, Jodi Taylor, Nicholas Turner, Sophie Rees, Joanna Thorn, Chris Metcalfe, Emily J Henderson, Clare Clement, Tomas J Welsh, Karen Sargent, Gemma Morgan, Derren Ready, Dominic Mellon, Liping Wen, Ruth Kipping, Alastair D Hay

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Randomised controlled trial to establish the clinical and cost-effectiveness of expectant management versus preoperative imaging with magnetic resonance cholangiopancreatography in... by Chris Rogers, Lucy Culliford, Natalie S Blencowe, Jane Blazeby, William Hollingworth, Kerry Avery, Marcus Jepson, Joanna Thorn, Raneem Albazaz, Barnaby Reeves, Madeleine Clout, Ravi Vohra, Samir Pathak, Ian Beckingham, Ashley Guthrie, Ewen A Griffiths, Giles Toogood, Michelle Lazaroo, Neil Jennings, Jane Collingwood, Elizabeth Booth

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Effectiveness and cost-effectiveness of guided self-help for depression for autistic adults: the Autism Depression Trial (ADEPT-2) – protocol for a multicentre, randomised controll... by Jeremy Horwood, Kirsty Garfield, Chris Metcalfe, Nicola Wiles, David Kessler, Joanna Thorn, Madeleine Clout, Dheeraj Rai, Barry Ingham, Peter Langdon, Ailsa Russell, Kate Cooper, Alba Realpe, Christine Russell, Liping Wen, Jessica Frost, Holly Emily Mckeon, Leonora Cotton, Rona Aldridge, Alison Cape, Dave Dagnan, Ed Dawn, Aikaterini Georgakopoulou, Vicky Jervis, Hannah Sheridan, Karolina Slowinska

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Sertraline for anxiety in adults with a diagnosis of autism (STRATA): study protocol for a pragmatic, multicentre, double-blind, placebo-controlled randomised controlled trial by Dheeraj Rai, Doug Webb, Amanda Lewis, Leonora Cotton, Jade Eloise Norris, Regi Alexander, David S. Baldwin, Traolach Brugha, Madeleine Cochrane, Maria Chiara Del Piccolo, Emma J. Glasson, Katherine K. Hatch, David Kessler, Peter E. Langdon, Helen Leonard, Stephanie J. MacNeill, Nicola Mills, Maximiliano Vazquez Morales, Zoe Morgan, Raja Mukherjee, Alba X. Realpe, Ailsa Russell, Sergio Starkstein, Jodi Taylor, Nicholas Turner, Joanna Thorn, Jack Welch, on behalf of the STRATA autistic advisory group, Nicola Wiles

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Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage by Alice-Maria Toader, Marion K. Campbell, Jennifer K. Quint, Michael Robling, Matthew R Sydes, Joanna Thorn, Alexandra Wright-Hughes, Ly-Mee Yu, Tom. E. F. Abbott, Simon Bond, Fergus J. Caskey, Madeleine Clout, Michelle Collinson, Bethan Copsey, Gwyneth Davies, Timothy Driscoll, Carrol Gamble, Xavier L. Griffin, Thomas Hamborg, Jessica Harris, David A. Harrison, Deena Harji, Emily J. Henderson, Pip Logan, Sharon B. Love, Laura A. Magee, Alastair O’Brien, Maria Pufulete, Padmanabhan Ramnarayan, Athanasios Saratzis, Jo Smith, Ivonne Solis-Trapala, Clive Stubbs, Amanda Farrin, Paula Williamson

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